- Light-driven oxygen production from superoxide by Mn-binding bacterial reaction centers
[作者:Allen, JP; Olson, TL; Oyala, P; Lee, WJ; Tufts, AA; Williams, JC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2314-2318 , 文章类型: Article,,卷期:2012年109-7]
- One of the outstanding questions concerning the early Earth is how ancient phototrophs made the evolutionary transition from anoxygenic to oxygenic photosynthesis, which resulted in a substantial increase in the amount o...
- Differential modulation of the default mode network via serotonin-1A receptors
[作者:Hahn, A; Wadsak, W; Windischberger, C; Baldinger, P; Hoflich, AS; Losak, J; Nics, L; Philippe, C; Kranz, GS; Kraus, C; Mitterhauser, M; Karanikas, G; Kasper, S; Lanzenberger, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2619-2624 , 文章类型: Article,,卷期:2012年109-7]
- Reflecting one's mental self is a fundamental process for evaluating the personal relevance of life events and for moral decision making and future envisioning. Although the corresponding network has been receiving growi...
- The human circadian metabolome
[作者:Dallmann, R; Viola, AU; Tarokh, L; Cajochen, C; Brown, SA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2625-2629 , 文章类型: Article,,卷期:2012年109-7]
- The circadian clock orchestrates many aspects of human physiology, and disruption of this clock has been implicated in various pathologies, ranging from cancer to metabolic syndrome and diabetes. Although there is eviden...
- Light stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling
[作者:Li, Y; Komuro, Y; Fahrion, JK; Hu, TF; Ohno, N; Fenner, KB; Wooton, J; Raoult, E; Galas, L; Vaudry, D; Komuro, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2630-2635 , 文章类型: Article,,卷期:2012年109-7]
- The role of genetic inheritance in brain development has been well characterized, but little is known about the contributions of natural environmental stimuli, such as the effect of light-dark cycles, to brain developmen...
- Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA
[作者:Pang, B; McFaline, JL; Burgis, NE; Dong, M; Taghizadeh, K; Sullivan, MR; Elmquist, CE; Cunningham, RP; Dedon, PC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2319-2324 , 文章类型: Article,,卷期:2012年109-7]
- Deamination of nucleobases in DNA and RNA results in the formation of xanthine (X), hypoxanthine (I), oxanine, and uracil, all of which are miscoding and mutagenic in DNA and can interfere with RNA editing and function. ...
- High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C
[作者:Willander, H; Askarieh, G; Landreh, M; Westermark, P; Nordling, K; Keranen, H; Hermansson, E; Hamvas, A; Nogee, LM; Bergman, T; Saenz, A; Casals, C; Aqvist, J; Jornvall, H; Berglund, H; Presto, J; Knight, SD; Johansson, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2325-2329 , 文章类型: Article,,卷期:2012年109-7]
- BRICHOS domains are encoded in >30 human genes, which are associated with cancer, neurodegeneration, and interstitial lung disease (ILD). The BRICHOS domain from lung surfactant protein C proprotein (proSP-C) is required...
- Aggregation of alpha-synuclein is kinetically controlled by intramolecular diffusion
[作者:Ahmad, B; Chen, YJ; Lapidus, LJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2336-2341 , 文章类型: Article,,卷期:2012年109-7]
- We hypothesize that the first step of aggregation of disordered proteins, such as alpha-synuclein, is controlled by the rate of backbone reconfiguration. When reconfiguration is fast, bimolecular association is not stabl...
- G(o)2 G protein mediates galanin inhibitory effects on insulin release from pancreatic beta cells
[作者:Tang, GH; Wang, Y; Park, S; Bajpayee, NS; Vi, D; Nagaoka, Y; Birnbaumer, L; Jiang, MS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2636-2641 , 文章类型: Article,,卷期:2012年109-7]
- The neuropeptide galanin regulates numerous physiological activities in the body, including feeding and metabolism, learning and memory, nociception and spinal reflexes, and anxiety and related behaviors. Modulation of b...
- Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice
[作者:Cooper, A; Grigoryan, G; Guy-David, L; Tsoory, MM; Chen, A; Reuveny, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2642-2647 , 文章类型: Article,,卷期:2012年109-7]
- G protein-activated inwardly rectifying K+ channels (GIRK) generate slow inhibitory postsynaptic potentials in the brain via G(i/o) protein-coupled receptors. GIRK2, a GIRK subunit, is widely abundant in the brain and ha...
- Mechanics of bacteriophage maturation
[作者:Roos, WH; Gertsman, I; May, ER; Brooks, CL; Johnson, JE; Wuite, GJL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2342-2347 , 文章类型: Article,,卷期:2012年109-7]
- Capsid maturation with large-scale subunit reorganization occurs in virtually all viruses that use a motor to package nucleic acid into preformed particles. A variety of ensemble studies indicate that the particles gain ...
- Extreme anti-oxidant protection against ionizing radiation in bdelloid rotifers
[作者:Krisko, A; Leroy, M; Radman, M; Meselson, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2354-2357 , 文章类型: Article,,卷期:2012年109-7]
- Bdelloid rotifers, a class of freshwater invertebrates, are extraordinarily resistant to ionizing radiation (IR). Their radioresistance is not caused by reduced susceptibility to DNA double-strand breakage for IR makes d...
- A long noncoding RNA regulates photoperiod-sensitive male sterility, an essential component of hybrid rice
[作者:Ding, JH; Lu, Q; Ouyang, YD; Mao, HL; Zhang, PB; Yao, JL; Xu, CG; Li, XH; Xiao, JH; Zhang, QF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2654-2659 , 文章类型: Article,,卷期:2012年109-7]
- Hybrid rice has greatly contributed to the global increase of rice productivity. Amajor component that facilitated the development of hybrids was a mutant showing photoperiod-sensitive male sterility (PSMS) with its fert...
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