- Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)
[作者:Zhu, JY; Yang, Y; Han, HJ; Betzi, S; Olesen, SH; Marsilio, F; Schonbrunn, E,期刊:Journal of Biological Chemistry, 页码:12657-12667 , 文章类型: Article,,卷期:2012年287-16]
- The enzyme MurA has been an established antibiotic target since the discovery of fosfomycin, which specifically inhibits MurA by covalent modification of the active site residue Cys-115. Early biochemical studies establi...
- ATP-dependent Mitochondrial Porphyrin Importer ABCB6 Protects against Phenylhydrazine Toxicity
[作者:Ulrich, DL; Lynch, J; Wang, Y; Fukuda, Y; Nachagari, D; Du, GQ; Sun, DX; Fan, YP; Tsurkan, L; Potter, PM; Rehg, JE; Schuetz, JD,期刊:Journal of Biological Chemistry, 页码:12679-12690 , 文章类型: Article,,卷期:2012年287-16]
- Abcb6 is a mammalian mitochondrial ATP-binding cassette (ABC) transporter that regulates de novo porphyrin synthesis. In previous studies, haploinsufficient (Abcb6(+/-)) embryonic stem cells showed impaired porphyrin syn...
- Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase
[作者:Montalvo-Ortiz, BL; Castillo-Pichardo, L; Hernandez, E; Humphries-Bickley, T; De La Mota-Peynado, A; Cubano, LA; Vlaar, CP; Dharmawardhane, S,期刊:Journal of Biological Chemistry, 页码:13228-13238 , 文章类型: Article,,卷期:2012年287-16]
- The Rho GTPase Rac regulates actin cytoskeleton reorganization to form cell surface extensions (lamellipodia) required for cell migration/invasion during cancer metastasis. Rac hyperactivation and overexpression are asso...
- Identification and Biochemical Characterization of Two Functional CMP-Sialic Acid Synthetases in Danio rerio
[作者:Schaper, W; Bentrop, J; Ustinova, J; Blume, L; Kats, E; Tiralongo, J; Weinhold, B; Bastmeyer, M; Munster-Kuhnel, AK,期刊:Journal of Biological Chemistry, 页码:13239-13248 , 文章类型: Article,,卷期:2012年287-16]
- Sialic acids (Sia) form the nonreducing end of the bulk of cell surface-expressed glycoconjugates. They are, therefore, major elements in intercellular communication processes. The addition of Sia to glycoconjugates requ...
- Phosphatidylserine Stimulation of Drs2p center dot Cdc50p Lipid Translocase Dephosphorylation Is Controlled by Phosphatidylinositol-4-phosphate
[作者:Jacquot, A; Montigny, C; Hennrich, H; Barry, R; le Maire, M; Jaxel, C; Holthuis, J; Champeil, P; Lenoir, G,期刊:Journal of Biological Chemistry, 页码:13249-13261 , 文章类型: Article,,卷期:2012年287-16]
- Here, Drs2p, a yeast lipid translocase that belongs to the family of P-4-type ATPases, was overexpressed in the yeast Saccharomyces cerevisiae together with Cdc50p, its glycosylated partner, as a result of the design of ...
- Phosphorylation of Doublecortin by Protein Kinase A Orchestrates Microtubule and Actin Dynamics to Promote Neuronal Progenitor Cell Migration
[作者:Toriyama, M; Mizuno, N; Fukami, T; Iguchi, T; Toriyama, M; Tago, K; Itoh, H,期刊:Journal of Biological Chemistry, 页码:12691-12702 , 文章类型: Article,,卷期:2012年287-16]
- Doublecortin (DCX) is a microtubule-associated protein that is specifically expressed in neuronal cells. Genetic mutation of DCX causes lissencephaly disease. Although the abnormal cortical lamination in lissencephaly is...
- Structure of Factor H-binding Protein B (FhbB) of the Periopathogen, Treponema denticola INSIGHTS INTO PROGRESSION OF PERIODONTAL DISEASE
[作者:Miller, DP; Bell, JK; McDowell, JV; Conrad, DH; Burgner, JW; Heroux, A; Marconi, RT,期刊:Journal of Biological Chemistry, 页码:12715-12722 , 文章类型: Article,,卷期:2012年287-16]
- Periodontitis is the most common disease of microbial etiology in humans. Periopathogen survival is dependent upon evasion of complement-mediated destruction. Treponema denticola, an important contributor to periodontiti...
- Peptidyl-prolyl Isomerase Pin1 Controls Down-regulation of Conventional Protein Kinase C Isozymes
[作者:Abrahamsen, H; O'Neill, AK; Kannan, N; Kruse, N; Taylor, SS; Jennings, PA; Newton, AC,期刊:Journal of Biological Chemistry, 页码:13262-13278 , 文章类型: Article,,卷期:2012年287-16]
- The down-regulation or cellular depletion of protein kinase C (PKC) attendant to prolonged activation by phorbol esters is a widely described property of this key family of signaling enzymes. However, neither the mechani...
- Context Surrounding Processing Sites Is Crucial in Determining Cleavage Rate of a Subset of Processing Sites in HIV-1 Gag and Gag-Pro-Pol Polyprotein Precursors by Viral Protease
[作者:Lee, SK; Potempa, M; Kolli, M; Ozen, A; Schiffer, CA; Swanstrom, R,期刊:Journal of Biological Chemistry, 页码:13279-13290 , 文章类型: Article,,卷期:2012年287-16]
- Processing of the human immunodeficiency virus type 1 (HIV-1) Gag and Gag-Pro-Pol polyproteins by the HIV-1 protease (PR) is essential for the production of infectious particles. However, the determinants governing the r...
- Kruppel-like Factor 11 Differentially Couples to Histone Acetyltransferase and Histone Methyltransferase Chromatin Remodeling Pathways to Transcriptionally Regulate Dopamine D2 Receptor in Neuronal Cells
[作者:Seo, S; Lomberk, G; Mathison, A; Buttar, N; Podratz, J; Calvo, E; Iovanna, J; Brimijoin, S; Windebank, A; Urrutia, R,期刊:Journal of Biological Chemistry, 页码:12723-12735 , 文章类型: Article,,卷期:2012年287-16]
- The importance of Kruppel-like factor (KLF)-mediated transcriptional pathways in the biochemistry of neuronal differentiation has been recognized relatively recently. Elegant studies have revealed that KLF proteins are i...
- GRK2 Protein-mediated Transphosphorylation Contributes to Loss of Function of mu-Opioid Receptors Induced by Neuropeptide FF (NPFF2) Receptors
[作者:Mouledous, L; Froment, C; Dauvillier, S; Burlet-Schiltz, O; Zajac, JM; Mollereau, C,期刊:Journal of Biological Chemistry, 页码:12736-12749 , 文章类型: Article,,卷期:2012年287-16]
- Neuropeptide FF (NPFF) interacts with specific receptors to modulate opioid functions in the central nervous system. On dissociated neurons and neuroblastoma cells (SH-SY5Y) transfected with NPFF receptors, NPFF acts as ...
- Silent Information Regulator 2 (Sir2) and Forkhead Box O (FOXO) Complement Mitochondrial Dysfunction and Dopaminergic Neuron Loss in Drosophila PTEN-induced Kinase 1 (PINK1) Null Mutant
[作者:Koh, H; Kim, H; Kim, MJ; Park, J; Lee, HJ; Chung, J,期刊:Journal of Biological Chemistry, 页码:12750-12758 , 文章类型: Article,,卷期:2012年287-16]
- PTEN-induced kinase 1 (PINK1), which is associated with early onset Parkinson disease, encodes a serine-threonine kinase that is critical for maintaining mitochondrial function. Moreover, another Parkinson disease-linked...
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