- Rice consumption contributes to arsenic exposure in US women
[作者:Gilbert-Diamond, D; Cottingham, KL; Gruber, JF; Punshon, T; Sayarath, V; Gandolfi, AJ; Baker, ER; Jackson, BP; Folt, CL; Karagas, MR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20656-20660 , 文章类型: Article,,卷期:2011年108-51]
- Emerging data indicate that rice consumption may lead to potentially harmful arsenic exposure. However, few human data are available, and virtually none exist for vulnerable periods such as pregnancy. Here we document a ...
- Visuoauditory mappings between high luminance and high pitch are shared by chimpanzees (Pan troglodytes) and humans
[作者:Ludwig, VU; Adachi, I; Matsuzawa, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20661-20665 , 文章类型: Article,,卷期:2011年108-51]
- Humans share implicit preferences for certain cross-sensory combinations; for example, they consistently associate higher-pitched sounds with lighter colors, smaller size, and spikier shapes. In the condition of synesthe...
- Heterozygote advantage as a natural consequence of adaptation in diploids
[作者:Sellis, D; Callahan, BJ; Petrov, DA; Messer, PW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20666-20671 , 文章类型: Article,,卷期:2011年108-51]
- Molecular adaptation is typically assumed to proceed by sequential fixation of beneficial mutations. In diploids, this picture presupposes that for most adaptive mutations, the homozygotes have a higher fitness than the ...
- Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes
[作者:Zhang, QH; Nishimura, D; Seo, S; Vogel, T; Morgan, DA; Searby, C; Bugge, K; Stone, EM; Rahmouni, K; Sheffield, VC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20678-20683 , 文章类型: Article,,卷期:2011年108-51]
- Bardet-Biedl syndrome (BBS) is a heterogeneous disorder characterized by obesity, retinopathy, polydactyly, and congenital anomalies. The incidence of hypertension and diabetes are also increased in BBS patients. Mutatio...
- Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1 alpha
[作者:Berda-Haddad, Y; Robert, S; Salers, P; Zekraoui, L; Farnarier, C; Dinarello, CA; Dignat-George, F; Kaplanski, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20684-20689 , 文章类型: Article,,卷期:2011年108-51]
- Sterile inflammation resulting from cell death is due to the release of cell contents normally inactive and sequestered within the cell; fragments of cell membranes from dying cells also contribute to sterile inflammatio...
- Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant
[作者:Zeitlin, L; Pettitt, J; Scully, C; Bohorova, N; Kim, D; Pauly, M; Hiatt, A; Ngo, L; Steinkellner, H; Whaley, KJ; Olinger, GG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20690-20694 , 文章类型: Article,,卷期:2011年108-51]
- No countermeasures currently exist for the prevention or treatment of the severe sequelae of Filovirus (such as Ebola virus; EBOV) infection. To overcome this limitation in our biodefense preparedness, we have designed m...
- A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge
[作者:Phoolcharoen, W; Dye, JM; Kilbourne, J; Piensook, K; Pratt, WD; Arntzen, CJ; Chen, Q; Mason, HS; Herbst-Kralovetz, MM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20695-20700 , 文章类型: Article,,卷期:2011年108-51]
- Ebola hemorrhagic fever is an acute and often deadly disease caused by Ebola virus (EBOV). The possible intentional use of this virus against human populations has led to design of vaccines that could be incorporated int...
- Antigen-specific induced Foxp3(+) regulatory T cells are generated following CD40/CD154 blockade
[作者:Ferrer, IR; Wagener, ME; Song, MQ; Kirk, AD; Larsen, CP; Ford, ML,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20701-20706 , 文章类型: Article,,卷期:2011年108-51]
- Blockade of the CD40/CD154 pathway potently attenuates T-cell responses in models of autoimmunity, inflammation, and transplantation. Indeed, CD40 pathway blockade remains one of the most powerful methods of prolonging g...
- A small molecule differentiation inducer increases insulin production by pancreatic beta cells
[作者:Dioum, EM; Osborne, JK; Goetsch, S; Russell, J; Schneider, JW; Cobb, MH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20713-20718 , 文章类型: Article,,卷期:2011年108-51]
- New drugs for preserving and restoring pancreatic beta-cell function are critically needed for the worldwide epidemic of type 2 diabetes and the cure for type 1 diabetes. We previously identified a family of neurogenic 3...
- Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands
[作者:Virostko, J; Henske, J; Vinet, L; Lamprianou, S; Dai, CH; Radhika, A; Baldwin, RM; Ansari, MS; Hefti, F; Skovronsky, D; Kung, HF; Herrera, PL; Peterson, TE; Meda, P; Powers, AC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20719-20724 , 文章类型: Article,,卷期:2011年108-51]
- We combined multimodal imaging (bioluminescence, X-ray computed tomography, and PET), tomographic reconstruction of bioluminescent sources, and two unique, complementary models to evaluate three previously synthesized PE...
- Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis
[作者:Osawa, T; Muramatsu, M; Wang, F; Tsuchida, R; Kodama, T; Minami, T; Shibuya, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20725-20729 , 文章类型: Article,,卷期:2011年108-51]
- Histone demethylase JHDM1D (also known as KDM7A) modifies the level of methylation in histone and participates in epigenetic gene regulation; however, the role of JHDM1D in tumor progression is unknown. Here, we show tha...
- Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells
[作者:Chakroborty, D; Sarkar, C; Yu, HM; Wang, J; Liu, ZF; Dasgupta, PS; Basu, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20730-20735 , 文章类型: Article,,卷期:2011年108-51]
- Impaired blood flow in the tumor vascular bed caused by structurally and functionally abnormal blood vessels not only hinders the delivery of chemotherapeutic agents but also aggravates tumor hypoxia, making the tumor ce...
- Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies
[作者:Bowers, PM; Horlick, RA; Neben, TY; Toobian, RM; Tomlinson, GL; Dalton, JL; Jones, HA; Chen, A; Altobell, L; Zhang, X; Macomber, JL; Krapf, IP; Wu, BF; McConnell, A; Chau, B; Holland, T; Berkebile, AD; Neben, SS; Boyle, WJ; King, DJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20455-20460 , 文章类型: Article,,卷期:2011年108-51]
- A novel approach has been developed for the isolation and maturation of human antibodies that replicates key features of the adaptive immune system by coupling in vitro somatic hypermutation (SHM) with mammalian cell dis...
- Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitors
[作者:Nagai, T; Unno, H; Janczak, MW; Yoshimura, T; Poulter, CD; Hemmi, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20461-20466 , 文章类型: Article,,卷期:2011年108-51]
- Evidence for an unusual catalysis of protonation/deprotonation by a reduced flavin mononucleotide cofactor is presented for type-2 isopentenyl diphosphate isomerase (IDI-2), which catalyzes isomerization of the two funda...
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