- Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site
[作者:Hatoum-Aslan, A; Maniv, I; Marraffini, LA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21218-21222 , 文章类型: Article,,卷期:2011年108-52]
- Precise RNA processing is fundamental to all small RNA-mediated interference pathways. In prokaryotes, clustered, regularly interspaced, short palindromic repeats (CRISPR) loci encode small CRISPR RNAs (crRNAs) that prot...
- Spontaneous generation of anchorless prions in transgenic mice
[作者:Stohr, J; Watts, JC; Legname, G; Oehler, A; Lemus, A; Nguyen, HOB; Sussman, J; Wille, H; DeArmond, SJ; Prusiner, SB; Giles, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21223-21228 , 文章类型: Article,,卷期:2011年108-52]
- Some prion protein mutations create anchorless molecules that cause Gerstmann-Straussler-Scheinker (GSS) disease. To model GSS, we generated transgenic mice expressing cellular prion protein (PrP(C)) lacking the glycosyl...
- Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo
[作者:Mower, AF; Kwok, S; Yu, HB; Majewska, AK; Okamoto, KI; Hayashi, Y; Sur, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21241-21246 , 文章类型: Article,,卷期:2011年108-52]
- Unbalanced visual input during development induces persistent alterations in the function and structure of visual cortical neurons. The molecular mechanisms that drive activity-dependent changes await direct visualizatio...
- Whole-body deletion of LPS-induced TNF-alpha factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis
[作者:Merrill, JC; You, J; Constable, C; Leeman, SE; Amar, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21247-21252 , 文章类型: Article,,卷期:2011年108-52]
- LPS-induced TNF-alpha factor (LITAF) mediates cytokine expression in response to endotoxin challenge. Previously, we reported that macrophage-specific LITAF-deficient (macLITAF(-/-)) mice exposed to LPS have a delayed on...
- Membrane protein complexes catalyze both 4-and 3-hydroxylation of cinnamic acid derivatives in monolignol biosynthesis
[作者:Chen, HC; Li, QZ; Shuford, CM; Liu, J; Muddiman, DC; Sederoff, RR; Chiang, VL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21253-21258 , 文章类型: Article,,卷期:2011年108-52]
- The hydroxylation of 4- and 3-ring carbons of cinnamic acid derivatives during monolignol biosynthesis are key steps that determine the structure and properties of lignin. Individual enzymes have been thought to catalyze...
- Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases
[作者:Ng, LM; Soon, FF; Zhou, XE; West, GM; Kovach, A; Suino-Powell, KM; Chalmers, MJ; Li, J; Yong, EL; Zhu, JK; Griffin, PR; Melcher, K; Xu, HE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21259-21264 , 文章类型: Article,,卷期:2011年108-52]
- Abscisic acid (ABA) is an essential hormone that controls plant growth, development, and responses to abiotic stresses. Central for ABA signaling is the ABA-mediated autoactivation of three monomeric Snf1-related kinases...
- FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders (vol 108, pg E1339, 2011)
[作者:Kiyota, T; Ingraham, KL; Jacobsen, MT; Xiong, HG; Ikezu, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21282-21282 , 文章类型: Correction,,卷期:2011年108-52]
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