- Identification of Essential Cannabinoid-binding Domains STRUCTURAL INSIGHTS INTO EARLY DYNAMIC EVENTS IN RECEPTOR ACTIVATION
[作者:Shim, JY; Bertalovitz, AC; Kendall, DA,期刊:Journal of Biological Chemistry, 页码:33422-33435 , 文章类型: Article,,卷期:2011年286-38]
- The classical cannabinoid agonist HU210, a structural analog of (-)-Delta(9)-tetrahydrocannabinol, binds to brain cannabinoid (CB1) receptors and activates signal transduction pathways. To date, an exact molecular descri...
- Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels
[作者:Miller, M; Shi, J; Zhu, YM; Kustov, M; Tian, JB; Stevens, A; Wu, M; Xu, J; Long, SY; Yang, P; Zholos, AV; Salovich, JM; Weaver, CD; Hopkins, CR; Lindsley, CW; McManus, O; Li, M; Zhu, MX,期刊:Journal of Biological Chemistry, 页码:33436-33446 , 文章类型: Article,,卷期:2011年286-38]
- Transient receptor potential canonical (TRPC) channels are Ca(2+)-permeable nonselective cation channels implicated in diverse physiological functions, including smooth muscle contractility and synaptic transmission. How...
- WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27(Kip1) Degradation in Human Diploid Fibroblasts
[作者:Cao, XX; Xue, LX; Han, LM; Ma, LW; Chen, TD; Tong, TJ,期刊:Journal of Biological Chemistry, 页码:33447-33456 , 文章类型: Article,,卷期:2011年286-38]
- WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) plays an important role in the proliferation of tumor cells and the lifespan of Caenorhabditis elegans. However, the role of WWP1 in cellular senescence is still ...
- The CXC Chemokine Receptor 4 Ligands Ubiquitin and Stromal Cell-derived Factor-1 alpha Function through Distinct Receptor Interactions
[作者:Saini, V; Staren, DM; Ziarek, JJ; Nashaat, ZN; Campbell, EM; Volkman, BF; Marchese, A; Majetschak, M,期刊:Journal of Biological Chemistry, 页码:33466-33477 , 文章类型: Article,,卷期:2011年286-38]
- Recently, we identified extracellular ubiquitin as an endogenous CXC chemokine receptor (CXCR) 4 agonist. However, the receptor selectivity and molecular basis of the CXCR4 agonist activity of ubiquitin are unknown, and ...
- Conditional Expression of the Androgen Receptor Induces Oncogenic Transformation of the Mouse Prostate
[作者:Zhu, CF; Luong, R; Zhuo, M; Johnson, DT; McKenney, JK; Cunha, GR; Sun, ZJ,期刊:Journal of Biological Chemistry, 页码:33478-33488 , 文章类型: Article,,卷期:2011年286-38]
- The androgen signaling pathway, mediated through the androgen receptor (AR), is critical in prostate tumorigenesis. However, the precise role of AR in prostate cancer development and progression still remains largely unk...
- Prion Protein Interacts with BACE1 Protein and Differentially Regulates Its Activity toward Wild Type and Swedish Mutant Amyloid Precursor Protein
[作者:Griffiths, HH; Whitehouse, IJ; Baybutt, H; Brown, D; Kellett, KAB; Jackson, CD; Turner, AJ; Piccardo, P; Manson, JC; Hooper, NM,期刊:Journal of Biological Chemistry, 页码:33489-33500 , 文章类型: Article,,卷期:2011年286-38]
- In Alzheimer disease amyloid-beta (A beta) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the beta-secretase BACE1 is the rate-limiting step in the production of A b...
- The Dystrophin-associated Protein Complex Maintains Muscle Excitability by Regulating Ca(2+)-dependent K(+) (BK) Channel Localization
[作者:Sancar, F; Touroutine, D; Gao, SB; Oh, HJ; Gendrel, M; Bessereau, JL; Kim, H; Zhen, M; Richmond, JE,期刊:Journal of Biological Chemistry, 页码:33501-33510 , 文章类型: Article,,卷期:2011年286-38]
- The dystrophin-associated protein complex (DAPC) consists of several transmembrane and intracellular scaffolding elements that have been implicated in maintaining the structure and morphology of the vertebrate neuromuscu...
- Comprehensive Analysis of Pathogen-specific Antibody Response in Vivo Based on an Antigen Library Displayed on Surface of Yeast
[作者:Zuo, T; Shi, XL; Liu, ZH; Guo, LL; Zhao, Q; Guan, TX; Pan, XM; Jia, N; Cao, WC; Zhou, BP; Goldin, M; Zhang, LQ,期刊:Journal of Biological Chemistry, 页码:33511-33519 , 文章类型: Article,,卷期:2011年286-38]
- Host antibody response is a crucial defense against pathogenic infection. Here, we report a novel technique allowing quantitative measurement of polyclonal antibody response in vivo. This involves expression of a combina...
- Epithelial Cell Adhesion Molecule (EpCAM) Complex Proteins Promote Transcription Factor-mediated Pluripotency Reprogramming
[作者:Huang, HP; Chen, PH; Yu, CY; Chuang, CY; Stone, L; Hsiao, WC; Li, CL; Tsai, SC; Chen, KY; Chen, HF; Ho, HN; Kuo, HC,期刊:Journal of Biological Chemistry, 页码:33520-33532 , 文章类型: Article,,卷期:2011年286-38]
- Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that is highly expressed in embryonic stem cells (ESCs) and its role in maintenance of pluripotency has been suggested previously. In epithelial c...
- NMR, Biophysical, and Biochemical Studies Reveal the Minimal Calmodulin Binding Domain of the HIV-1 Matrix Protein
[作者:Samal, AB; Ghanam, RH; Fernandez, TF; Monroe, EB; Saad, JS,期刊:Journal of Biological Chemistry, 页码:33533-33543 , 文章类型: Article,,卷期:2011年286-38]
- Subcellular distribution of Calmodulin (CaM) in human immunodeficiency virus type-1 (HIV-1)-infected cells is distinct from that observed in uninfected cells. CaM has been shown to interact and co-localize with the HIV-1...
- Conformational Regulation of Urokinase Receptor Function IMPACT OF RECEPTOR OCCUPANCY AND EPITOPE-MAPPED MONOCLONAL ANTIBODIES ON LAMELLIPODIA INDUCTION
[作者:Gardsvoll, H; Jacobsen, B; Kriegbaum, MC; Behrendt, N; Engelholm, L; Ostergaard, S; Ploug, M,期刊:Journal of Biological Chemistry, 页码:33544-33556 , 文章类型: Article,,卷期:2011年286-38]
- The urokinase-type plasminogen activator receptor ( uPAR) is a glycolipid-anchored membrane protein with an established role in focalizing uPA-mediated plasminogen activation on cell surfaces. Distinct from this function...
- Mechanisms of Slower Nitric Oxide Uptake by Red Blood Cells and Other Hemoglobin-containing Vesicles
[作者:Azarov, I; Liu, C; Reynolds, H; Tsekouras, Z; Lee, JS; Gladwin, MT; Kim-Shapiro, DB,期刊:Journal of Biological Chemistry, 页码:33567-33579 , 文章类型: Article,,卷期:2011年286-38]
- Nitric oxide (NO) acts as a smooth muscle relaxation factor and plays a crucial role in maintaining vascular homeostasis. NO is scavenged rapidly by hemoglobin (Hb). However, under normal physiological conditions, the en...
- The Heme Oxygenase-1 Protein Is Overexpressed in Human Renal Cancer Cells following Activation of the Ras-Raf-ERK Pathway and Mediates Anti-Apoptotic Signal
[作者:Banerjee, P; Basu, A; Datta, D; Gasser, M; Waaga-Gasser, AM; Pal, S,期刊:Journal of Biological Chemistry, 页码:33580-33590 , 文章类型: Article,,卷期:2011年286-38]
- The stress-inducible cytoprotective enzyme heme oxygenase-1 (HO-1) may play a critical role in the growth and metastasis of tumors. We demonstrated that overexpressed HO-1 promotes the survival of renal cancer cells by i...
- Dietary Isothiocyanate-induced Apoptosis via Thiol Modification of DNA Topoisomerase II alpha
[作者:Lin, RK; Zhou, N; Lyu, YL; Tsai, YC; Lu, CH; Kerrigan, J; Chen, YT; Guan, Z; Hsieh, TS; Liu, LF,期刊:Journal of Biological Chemistry, 页码:33591-33600 , 文章类型: Article,,卷期:2011年286-38]
- Studies in animal models have indicated that dietary isothiocyanates (ITCs) exhibit cancer preventive activities through carcinogen detoxification-dependent and -independent mechanisms. The carcinogen detoxification-inde...
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