- Phospholamban Binds with Differential Affinity to Calcium Pump Conformers
[作者:Bidwell, P; Blackwell, DJ; Hou, ZJ; Zima, AV; Robia, SL,期刊:Journal of Biological Chemistry, 页码:35044-35050 , 文章类型: Article,,卷期:2011年286-40]
- To investigate the mechanism of regulation of sarco-endo-plasmic reticulum Ca(2+)-ATPase (SERCA) by phospholamban (PLB), we expressed Cerulean-SERCA and yellow fluorescent protein (YFP)-PLB in adult rabbit ventricular my...
- Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V
[作者:Preller, M; Bauer, S; Adamek, N; Fujita-Becker, S; Fedorov, R; Geeves, MA; Manstein, DJ,期刊:Journal of Biological Chemistry, 页码:35051-35060 , 文章类型: Article,,卷期:2011年286-40]
- The cold-sensitive single-residue mutation of glycine 680 in the reactive thiol region of Dictyostelium discoideum myosin-2 or the corresponding conserved glycine in other myosin isoforms has been reported to interfere w...
- Receptor for Advanced Glycation End Products (RAGE) Prevents Endothelial Cell Membrane Resealing and Regulates F-actin Remodeling in a beta-Catenin-dependent Manner
[作者:Xiong, F; Leonov, S; Howard, AC; Xiong, S; Zhang, B; Mei, L; McNeil, P; Simon, S; Xiong, WC,期刊:Journal of Biological Chemistry, 页码:35061-35070 , 文章类型: Article,,卷期:2011年286-40]
- Receptor for advanced glycation end products (RAGE), an immunoglobin superfamily cell surface receptor, contributes to the vascular pathology associated with multiple disorders, including Alzheimer disease (AD), diabetic...
- c-Jun N-terminal Kinase (JNK)-dependent Acute Liver Injury from Acetaminophen or Tumor Necrosis Factor (TNF) Requires Mitochondrial Sab Protein Expression in Mice
[作者:Win, S; Than, TA; Han, D; Petrovic, LM; Kaplowitz, N,期刊:Journal of Biological Chemistry, 页码:35071-35078 , 文章类型: Article,,卷期:2011年286-40]
- Sustained JNK activation plays a critical role in hepatotoxicity by acetaminophen or GalN/TNF-alpha. To address the importance of JNK translocation to mitochondria that accompanies sustained activation in these models, w...
- Structural Basis for Agonism and Antagonism for a Set of Chemically Related Progesterone Receptor Modulators
[作者:Lusher, SJ; Raaijmakers, HCA; Vu-Pham, D; Dechering, K; Lam, TW; Brown, AR; Hamilton, NM; Nimz, O; Bosch, R; McGuire, R; Oubrie, A; de Vlieg, J,期刊:Journal of Biological Chemistry, 页码:35079-35086 , 文章类型: Article,,卷期:2011年286-40]
- The progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween...
- Determining beta(2)-Integrin and Intercellular Adhesion Molecule 1 Binding Kinetics in Tumor Cell Adhesion to Leukocytes and Endothelial Cells by a Gas-driven Micropipette Assay
[作者:Fu, CL; Tong, CF; Wang, ML; Gao, YX; Zhang, Y; Lu, SQ; Liang, SL; Dong, C; Long, MA,期刊:Journal of Biological Chemistry, 页码:34777-34787 , 文章类型: Article,,卷期:2011年286-40]
- Interactions between polymorphonuclear neutrophils (PMNs) and tumor cells have been reported to facilitate the adhesion and subsequent extravasation of tumor cells through the endothelium under blood flow, both of which ...
- Single-stranded Noncoding RNAs Mediate Local Epigenetic Alterations at Gene Promoters in Rat Cell Lines
[作者:Tomikawa, J; Shimokawa, H; Uesaka, M; Yamamoto, N; Mori, Y; Tsukamura, H; Maeda, K; Imamura, T,期刊:Journal of Biological Chemistry, 页码:34788-34799 , 文章类型: Article,,卷期:2011年286-40]
- Agrowing number of noncoding RNAs (ncRNAs) are thought to be involved in sequence-specific alterations of epigenetic processes, mostly causing gene repression. In this study, promoterassociated ncRNAs (pancRNAs > 200 nuc...
- L-Tryptophan-mediated Enhancement of Susceptibility to Nonalcoholic Fatty Liver Disease Is Dependent on the Mammalian Target of Rapamycin
[作者:Osawa, Y; Kanamori, H; Seki, E; Hoshi, M; Ohtaki, H; Yasuda, Y; Ito, H; Suetsugu, A; Nagaki, M; Moriwaki, H; Saito, K; Seishima, M,期刊:Journal of Biological Chemistry, 页码:34800-34808 , 文章类型: Article,,卷期:2011年286-40]
- Nonalcoholic fatty liver disease is one of the most common liver diseases. L-Tryptophan and its metabolite serotonin are involved in hepatic lipid metabolism and inflammation. However, it is unclear whether L-tryptophan ...
- 93-kDa Twin-domain Serine Protease Inhibitor (Serpin) Has a Regulatory Function on the Beetle Toll Proteolytic Signaling Cascade
[作者:Jiang, R; Zhang, B; Kurokawa, K; So, YI; Kim, EH; Hwang, HO; Lee, JH; Shiratsuchi, A; Zhang, JH; Nakanishi, Y; Lee, HS; Lee, BL,期刊:Journal of Biological Chemistry, 页码:35087-35095 , 文章类型: Article,,卷期:2011年286-40]
- Serpins are protease inhibitors that play essential roles in the down-regulation of extracellular proteolytic cascades. The core serpin domain is highly conserved, and typical serpins are encoded with a molecular size of...
- The Rickettsia Surface Cell Antigen 4 Applies Mimicry to Bind to and Activate Vinculin.
[作者:Park, H; Lee, JH; Gouin, E; Cossart, P; Izard, T,期刊:Journal of Biological Chemistry, 页码:35096-35103 , 文章类型: Article,,卷期:2011年286-40]
- Pathogenic Rickettsia species cause high morbidity and mortality, especially R. prowazekii, the causative agent of typhus. Like many intracellular pathogens, Rickettsia exploit the cytoskeleton to enter and spread within...
- Intracellular Erythrocyte Platelet-activating Factor Acetylhydrolase I Inactivates Aspirin in Blood
[作者:Zhou, G; Marathe, GK; Willard, B; McIntyre, TM,期刊:Journal of Biological Chemistry, 页码:34820-34829 , 文章类型: Article,,卷期:2011年286-40]
- Aspirin (acetylsalicylic acid) prophylaxis suppresses major adverse cardiovascular events, but its rapid turnover limits inhibition of platelet cyclooxygenase activity and thrombosis. Despite its importance, the identity...
- Selenoprotein K Is a Novel Target of m-Calpain, and Cleavage Is Regulated by Toll-like Receptor-induced Calpastatin in Macrophages
[作者:Huang, Z; Hoffmann, FW; Norton, RL; Hashimoto, AC; Hoffmann, PR,期刊:Journal of Biological Chemistry, 页码:34830-34838 , 文章类型: Article,,卷期:2011年286-40]
- Calpains are proteolytic enzymes that modulate cellular function through cleavage of targets, thereby modifying their actions. An important role is emerging for calpains in regulating inflammation and immune responses, a...
- The IQGAP1 Protein Is a Calmodulin-regulated Barbed End Capper of Actin Filaments POSSIBLE IMPLICATIONS IN ITS FUNCTION IN CELL MIGRATION
[作者:Pelikan-Conchaudron, A; Le Clainche, C; Didry, D; Carlier, MF,期刊:Journal of Biological Chemistry, 页码:35119-35128 , 文章类型: Article,,卷期:2011年286-40]
- IQGAP1 is a large modular protein that displays multiple partnership and is thought to act as a scaffold in coupling cell signaling to the actin and microtubule cytoskeletons in cell migration, adhesion, and cytokinesis....
|