- Pigment Epithelium-derived Factor (PEDF) Promotes Tumor Cell Death by Inducing Macrophage Membrane Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)
[作者:Ho, TC; Chen, SL; Shih, SC; Chang, SJ; Yang, SL; Hsieh, JW; Cheng, HC; Chen, LJ; Tsao, YP,期刊:Journal of Biological Chemistry, 页码:35943-35954 , 文章类型: Article,,卷期:2011年286-41]
- Pigment epithelium-derived factor (PEDF) is an intrinsic anti-angiogenic factor and a potential anti-tumor agent. The tumoricidal mechanism of PEDF, however, has not been fully elucidated. Here we report that PEDF induce...
- Orphan Macrodomain Protein (Human C6orf130) Is an O-Acyl-ADP-ribose Deacylase SOLUTION STRUCTURE AND CATALYTIC PROPERTIES
[作者:Peterson, FC; Chen, DW; Lytle, BL; Rossi, MN; Ahel, I; Denu, JM; Volkman, BF,期刊:Journal of Biological Chemistry, 页码:35955-35965 , 文章类型: Article,,卷期:2011年286-41]
- Background: Protein deacylation by sirtuins yields O-acyl-ADP-ribose molecules, which are implicated in cell signaling and metabolism. Results: Structural and functional analysis of a human orphan macrodomain protein rev...
- Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism
[作者:Harper, CB; Martin, S; Nguyen, TH; Daniels, SJ; Lavidis, NA; Popoff, MR; Hadzic, G; Mariana, A; Chau, N; McCluskey, A; Robinson, PJ; Meunier, FA,期刊:Journal of Biological Chemistry, 页码:35966-35976 , 文章类型: Article,,卷期:2011年286-41]
- The botulinum neurotoxins (BoNTs) are di-chain bacterial proteins responsible for the paralytic disease botulism. Following binding to the plasma membrane of cholinergic motor nerve terminals, BoNTs are internalized into...
- Identification of a Cytochrome P4502E1/Bid/C1q-dependent Axis Mediating Inflammation in Adipose Tissue after Chronic Ethanol Feeding to Mice
[作者:Sebastian, BM; Roychowdhury, S; Tang, H; Hillian, AD; Feldstein, AE; Stahl, GL; Takahashi, K; Nagy, LE,期刊:Journal of Biological Chemistry, 页码:35989-35997 , 文章类型: Article,,卷期:2011年286-41]
- Background: Chronic alcohol consumption leads to inflammation in adipose tissue, disrupting normal metabolic activity of adipocytes. Results: Expression of an alcohol metabolizing enzyme, cytochrome P4502E1, initiates in...
- Calpain-cleaved Type 1 Inositol 1,4,5-Trisphosphate Receptor (InsP(3)R1) Has InsP(3)-independent Gating and Disrupts Intracellular Ca(2+) Homeostasis
[作者:Kopil, CM; Vais, H; Cheung, KH; Siebert, AP; Mak, DOD; Foskett, JK; Neumar, RW,期刊:Journal of Biological Chemistry, 页码:35998-36010 , 文章类型: Article,,卷期:2011年286-41]
- The type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) is a ubiquitous intracellular Ca(2+) release channel that is vital to intracellular Ca(2+) signaling. InsP(3)R1 is a proteolytic target of calpain, which cleav...
- The Inhibitory Effect of Phospholemman on the Sodium Pump Requires Its Palmitoylation
[作者:Tulloch, LB; Howie, J; Wypijewski, KJ; Wilson, CR; Bernard, WG; Shattock, MJ; Fuller, W,期刊:Journal of Biological Chemistry, 页码:36020-36031 , 文章类型: Article,,卷期:2011年286-41]
- Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart. Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodiu...
- Inhibitors of Src and Focal Adhesion Kinase Promote Endocrine Specification IMPACT ON THE DERIVATION OF beta-CELLS FROM HUMAN PLURIPOTENT STEM CELLS
[作者:Afrikanova, I; Yebra, M; Simpkinson, M; Xu, Y; Hayek, A; Montgomery, A,期刊:Journal of Biological Chemistry, 页码:36042-36052 , 文章类型: Article,,卷期:2011年286-41]
- Stepwise approaches for the derivation of beta-cells from human embryonic stem cells have been described. However, low levels of endocrine specification limit the final yield of insulin-producing beta-cells. In this stud...
- Sphingomyelin Synthase 1-generated Sphingomyelin Plays an Important Role in Transferrin Trafficking and Cell Proliferation
[作者:Shakor, ABA; Taniguchi, M; Kitatani, K; Hashimoto, M; Asano, S; Hayashi, A; Nomura, K; Bielawski, J; Bielawska, A; Watanabe, K; Kobayashi, T; Igarashi, Y; Umehara, H; Takeya, H; Okazaki, T,期刊:Journal of Biological Chemistry, 页码:36053-36062 , 文章类型: Article,,卷期:2011年286-41]
- Transferrin (Tf) endocytosis and recycling are essential for iron uptake and the regulation of cell proliferation. Tf and Tf receptor (TfR) complexes are internalized via clathrin-coated pits composed of a variety of pro...
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