- Synthesis, characterization, antiamoebic activity and cytotoxicity of novel 2-(quinolin-8-yloxy) acetohydrazones and their cyclized products (1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives)
[作者:Hayat, F; Salahuddin, A; Zargan, J; Azam, A,期刊:European Journal of Medicinal Chemistry, 页码:6127-6134 , 文章类型: Article,,卷期:2010年45-12]
- A series of 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives were synthesized by the cyclization of novel 2-(quinolin-8-yloxy) acetohydrazones. In vitro antiamoebic activity was performed against HM1: IMSS strain of...
- Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors
[作者:Fioravanti, R; Bolasco, A; Manna, F; Rossi, F; Orallo, F; Ortuso, F; Alcaro, S; Cirilli, R,期刊:European Journal of Medicinal Chemistry, 页码:6135-6138 , 文章类型: Article,,卷期:2010年45-12]
- Eighteen new 1-N-substituted-3,5-diphenyl-2-pyrazoline derivatives have been synthesized and cyclooxygenase (COX-1 and COX-2) inhibitory activities have been evaluated. The results of these biological assays showed that ...
- A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation
[作者:Prasanna, P; Balamurugan, K; Perumal, S; Yogeeswari, P; Sriram, D,期刊:European Journal of Medicinal Chemistry, 页码:5653-5661 , 文章类型: Article,,卷期:2010年45-12]
- The 1,3-dipolar cycloaddition of azomethine ylides derived from substituted isatins and 1,3-thiazolane-4-carboxylic acid to a series of 2-(arylmethylene)-2,3-dihydro-1H-inden-1-ones afforded twenty nine novel spiro-pyrro...
- Mitogen-activated protein kinase 4 of Leishmania parasite as a therapeutic target
[作者:Saravanan, P; Venkatesan, SK; Mohan, CG; Patra, S; Dubey, VK,期刊:European Journal of Medicinal Chemistry, 页码:5662-5670 , 文章类型: Article,,卷期:2010年45-12]
- Protein kinases are important regulators of many different cellular processes such as transcriptional control, cell cycle progression and differentiation, and have drawn much attention as potential drug targets. Leishman...
- 2-Acetylpyridine thiosemicarbazones: Cytotoxic activity in nanomolar doses against malignant gliomas
[作者:Lessa, JA; Mendes, IC; da Silva, PRO; Soares, MA; dos Santos, RG; Speziali, NL; Romeiro, NC; Barreiro, EJ; Beraldo, H,期刊:European Journal of Medicinal Chemistry, 页码:5671-5677 , 文章类型: Article,,卷期:2010年45-12]
- 2-Acetylpyridine N(4)-phenyl thiosemicarbazone (H2Ac4Ph), and its N(4)-ortho-tolyl (H2Ac4oT), N(4)meta-tolyl (H2Ac4mT), N(4)-para-toly1 (H2Ac4pT), N(4)-ortho-chlorophenyl (H2Ac4oClPh), N(4)-meta-chlorophenyl (H2Ac4mClPh)...
- Synthesis, biological evaluation and docking studies of 4-amino-tetrahydroquinazolino[3,2-e]purine derivatives
[作者:Verones, V; Flouquet, N; Farce, A; Carato, P; Leonce, S; Pfeiffer, B; Berthelot, P; Lebegue, N,期刊:European Journal of Medicinal Chemistry, 页码:5678-5684 , 文章类型: Article,,卷期:2010年45-12]
- The synthesis of new 4-amino-tetrahydroquinazolino[3,2-e]purine derivatives along with their activity in cell-free enzymatic assays on Src is reported. Some compounds emerged as moderately active inhibitors of the enzyme...
- Synthesis and antimicrobial evaluation of some fused heterocyclic [1,2,4]triazolo [3,4-b][1,3,4]thiadiazole derivatives
[作者:Almajan, GL; Barbuceanu, SF; Bancescu, G; Saramet, I; Saramet, G; Draghici, C,期刊:European Journal of Medicinal Chemistry, 页码:6139-6146 , 文章类型: Article,,卷期:2010年45-12]
- A series of fused 1,2,4-triazoles with diphenylsulfone moiety are prepared utilizing 4-amino-5-[4-(4-X-phenylsulfonyl)phenyl]-4H-1,2,4-triazole-3-thiol 1 (X = H, Br). The latter on reaction with aromatic isothiocyanate i...
- Pharmacophore model for pentamidine analogs active against Plasmodium falciparum
[作者:Athri, P; Wenzler, T; Tidwell, R; Bakunova, SM; Wilson, WD,期刊:European Journal of Medicinal Chemistry, 页码:6147-6151 , 文章类型: Article,,卷期:2010年45-12]
- Pentamidine and its analogs constitute a class of compounds that are known to be active against Plasmodium falciparum, which causes the most dangerous malarial infection. Malaria is a widespread disease known to affect h...
- Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases
[作者:Gonzalez-Munoz, GC; Arce, MP; Lopez, B; Perez, C; Villarroya, M; Lopez, MG; Garcia, AG; Conde, S; Rodriguez-Franco, MI,期刊:European Journal of Medicinal Chemistry, 页码:6152-6158 , 文章类型: Article,,卷期:2010年45-12]
- From an in-house library of compounds, five phenothiazines and one dibenzothiadiazepine were selected to be tested in neuroprotective and cholinergic assays. Three of them, derived from the N-alkylphenothiazine, the N-ac...
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