- Cytochrome P450 2B1 Mediates Complement-dependent Sublytic Injury in a Model of Membranous Nephropathy
[作者:Liu, H; Tian, N; Arany, I; Bigler, SA; Waxman, DJ; Shah, SV; Baliga, R,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- Membranous nephropathy is a disease that affects the filtering units of the kidney, the glomeruli, and results in proteinuria accompanied by loss of kidney function. Passive Heymann nephritis is an experimental model tha...
- Directed Evolution of a Thermostable Quorum-quenching Lactonase from the Amidohydrolase Superfamily
[作者:Chow, JY; Xue, B; Lee, KH; Tung, A; Wu, L; Robinson, RC; Yew, WS,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- A thermostable quorum-quenching lactonase from Geobacillus kaustophilus HTA426 (GI: 56420041) was used as an initial template for in vitro directed evolution experiments. This enzyme belongs to the phosphotriesterase-lik...
- The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice and Lepr(db/db) Mice
[作者:Saha, PK; Reddy, VT; Konopleva, M; Andreeff, M; Chan, L,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- The triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid (CDDO) and its methyl ester (CDDO-Me) are undergoing clinical trials in cancer and leukemia therapy. Here we report that CDDO-Me ameliorates diabetes in high...
- Tomosyn Inhibits Synaptotagmin-1-mediated Step of Ca2+- dependent Neurotransmitter Release through Its N-terminal WD40 Repeats
[作者:Yamamoto, Y; Mochida, S; Miyazaki, N; Kawai, K; Fujikura, K; Kurooka, T; Iwasaki, K; Sakisaka, T,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- Neurotransmitter release is triggered by Ca2+ binding to a low affinity Ca2+ sensor, mostly synaptotagmin-1, which catalyzes SNARE-mediated synaptic vesicle fusion. Tomosyn negatively regulates Ca2+ -dependent neurotrans...
- Perturbed Amelogenin Secondary Structure Leads to Uncontrolled Aggregation in Amelogenesis Imperfecta Mutant Proteins
[作者:Lakshminarayanan, R; Bromley, KM; Lei, YP; Snead, ML; Moradian-Oldak, J,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- Mutations in amelogenin sequence result in defective enamel, and the diverse group of genetically altered conditions is collectively known as amelogenesis imperfecta (AI). Despite numerous studies, the detailed molecular...
- Small Molecule Mimetics of an HIV-1 gp41 Fusion Intermediate as Vaccine Leads
[作者:Caulfield, MJ; Dudkin, VY; Ottinger, EA; Getty, KL; Zuck, PD; Kaufhold, RM; Hepler, RW; McGaughey, GB; Citron, M; Hrin, RC; Wang, YJ; Miller, MD; Joyce, JG,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- We describe here a novel platform technology for the discovery of small molecule mimetics of conformational epitopes on protein antigens. As a model system, we selected mimetics of a conserved hydrophobic pocket within t...
- Smac Mimetic Compounds Potentiate Interleukin-1 beta-mediated Cell Death
[作者:Cheung, HH; Beug, ST; Jean, MS; Brewster, A; Kelly, NL; Wang, SM; Korneluk, RG,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- Smac mimetic compounds (SMCs) potentiate TNF beta-mediated cancer cell death by targeting the inhibitor of apoptosis (IAP) proteins. In addition to TNF alpha, the tumor microenvironment is exposed to a number of pro-infl...
- Local Sequence Targeting in the AID/APOBEC Family Differentially Impacts Retroviral Restriction and Antibody Diversification
[作者:Kohli, RM; Maul, RW; Guminski, AF; McClure, RL; Gajula, KS; Saribasak, H; McMahon, MA; Siliciano, RF; Gearhart, PJ; Stivers, JT,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- Nucleic acid cytidine deaminases of the activation-induced deaminase (AID)/APOBEC family are critical players in active and innate immune responses, playing roles as target-directed, purposeful mutators. AID specifically...
- Effects of the Prosegment and pH on the Activity of PCSK9 EVIDENCE FOR ADDITIONAL PROCESSING EVENTS
[作者:Benjannet, S; Saavedra, YGL; Hamelin, J; Asselin, MC; Essalmani, R; Pasquato, A; Lemaire, P; Duke, G; Miao, B; Duclos, F; Parker, R; Mayer, G; Seidah, NG,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- PCSK9, a target for the treatment of dyslipidemia, enhances the degradation of the LDL receptor (LDLR) in endosomes/lysosomes, up-regulating LDL-cholesterol levels. Whereas the targeting and degradation of the PCSK9-LDLR...
- Annexin 2 Regulates Endothelial Morphogenesis by Controlling AKT Activation and Junctional Integrity
[作者:Su, SC; Maxwell, SA; Bayless, KJ,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- Sprouting angiogenesis is a multistep process that involves endothelial cell activation, basement membrane degradation, proliferation, lumen formation, and stabilization. In this study, we identified annexin 2 as a regul...
- Crystal Structure of Cardiac-specific Histone Methyltransferase SmyD1 Reveals Unusual Active Site Architecture
[作者:Sirinupong, N; Brunzelle, J; Ye, J; Pirzada, A; Nico, L; Yang, Z,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- SmyD1 is a cardiac-and muscle-specific histone methyltransferase that methylates histone H3 at lysine 4 and regulates gene transcription in early heart development. The unique domain structure characterized by a "split" ...
- Albumin-based Microbubbles Bind Up-regulated Scavenger Receptors following Vascular Injury
[作者:Anderson, DR; Duryee, MJ; Anchan, RK; Garvin, RP; Johnston, MD; Porter, TR; Thiele, GM; Klassen, LW,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- We have shown previously that perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles bind to injured vascular tissue and can be detected with ultrasound imaging techniques. Prior studies have shown that ...
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