- Phospholipid Scramblase 1 Is Secreted by a Lipid Raft-dependent Pathway and Interacts with the Extracellular Matrix Protein 1 in the Dermal Epidermal Junction Zone of Human Skin
[作者:Merregaert, J; Van Langen, J; Hansen, U; Ponsaerts, P; El Ghalbzouri, A; Steenackers, E; Van Ostade, X; Sercu, S,期刊:Journal of Biological Chemistry, 页码:37823-37837 , 文章类型: Article,,卷期:2010年285-48]
- We examined the interaction of ECM1 (extracellular matrix protein 1) using yeast two-hybrid screening and identified the type II transmembrane protein, PLSCR1 (phospholipid scramblase 1), as a binding partner. This inter...
- Biochemical and Spectroscopic Characterization of the Human Mitochondrial Amidoxime Reducing Components hmARC-1 and hmARC-2 Suggests the Existence of a New Molybdenum Enzyme Family in Eukaryotes
[作者:Wahl, B; Reichmann, D; Niks, D; Krompholz, N; Havemeyer, A; Clement, B; Messerschmidt, T; Rothkegel, M; Biester, H; Hille, R; Mendel, RR; Bittner, F,期刊:Journal of Biological Chemistry, 页码:37847-37859 , 文章类型: Article,,卷期:2010年285-48]
- The mitochondrial amidoxime reducing componentm ARC is a newly discovered molybdenum enzyme that is presumed to form the catalytical part of a three-component enzyme system, consisting of mARC, heme/cytochrome b(5), and ...
- Phosphorylation of Enoyl-Acyl Carrier Protein Reductase InhA Impacts Mycobacterial Growth and Survival
[作者:Khan, S; Nagarajan, SN; Parikh, A; Samantaray, S; Singh, A; Kumar, D; Roy, RP; Bhatt, A; Nandicoori, VK,期刊:Journal of Biological Chemistry, 页码:37860-37871 , 文章类型: Article,,卷期:2010年285-48]
- InhA, the primary target for the first line anti-tuberculosis drug isoniazid, is a key enzyme of the fatty-acid synthase II system involved in mycolic acid biosynthesis in Mycobacterium tuberculosis. In this study, we sh...
- Cobra CRISP Functions as an Inflammatory Modulator via a Novel Zn2+- and Heparan Sulfate-dependent Transcriptional Regulation of Endothelial Cell Adhesion Molecules
[作者:Wang, YL; Kuo, JH; Lee, SC; Liu, JS; Hsieh, YC; Shih, YT; Chen, CJ; Chiu, JJ; Wu, WG,期刊:Journal of Biological Chemistry, 页码:37872-37883 , 文章类型: Article,,卷期:2010年285-48]
- Cysteine-rich secretory proteins (CRISPs) have been identified as a toxin family in most animal venoms with biological functions mainly associated with the ion channel activity of cysteine-rich domain (CRD). CRISPs also ...
- Whole Body Deletion of AMP-activated Protein Kinase beta 2 Reduces Muscle AMPK Activity and Exercise Capacity
[作者:Steinberg, GR; O'Neill, HM; Dzamko, NL; Galic, S; Naim, T; Koopman, R; Jorgensen, SB; Honeyman, J; Hewitt, K; Chen, ZP; Schertzer, JD; Scott, JW; Koentgen, F; Lynch, GS; Watt, MJ; van Denderen, BJW; Campbell, DJ; Kemp, BE,期刊:Journal of Biological Chemistry, 页码:37198-37209 , 文章类型: Article,,卷期:2010年285-48]
- AMP-activated protein kinase (AMPK) beta subunits (beta 1 and beta 2) provide scaffolds for binding alpha and gamma subunits and contain a carbohydrate-binding module important for regulating enzyme activity. We generate...
- Chronic Ethanol Consumption-induced Pancreatic beta-Cell Dysfunction and Apoptosis through Glucokinase Nitration and Its Down-regulation
[作者:Kim, JY; Song, EH; Lee, HJ; Oh, YK; Park, YS; Park, JW; Kim, BJ; Kim, DJ; Lee, I; Song, J; Kim, WH,期刊:Journal of Biological Chemistry, 页码:37251-37262 , 文章类型: Article,,卷期:2010年285-48]
Chronic ethanol consumption is known as an independent risk factor for type 2 diabetes, which is characterized by impaired glucose homeostasis and insulin resistance; however, there is a great deal of controversy conc...
- Substrates of the Arabidopsis thaliana Protein Isoaspartyl Methyltransferase 1 Identified Using Phage Display and Biopanning
[作者:Chen, TS; Nayak, N; Majee, SM; Lowenson, J; Schafermeyer, KR; Eliopoulos, AC; Lloyd, TD; Dinkins, R; Perry, SE; Forsthoefel, NR; Clarke, SG; Vernon, DM; Zhou, ZS; Rejtar, T; Downie, AB,期刊:Journal of Biological Chemistry, 页码:37281-37292 , 文章类型: Article,,卷期:2010年285-48]
- The role of protein isoaspartyl methyltransferase (PIMT) in repairing a wide assortment of damaged proteins in a host of organisms has been inferred from the affinity of the enzyme for isoaspartyl residues in a plethora ...
- Suppression of Expression of Endoplasmic Reticulum Chaperones by Helicobacter pylori and Its Role in Exacerbation of Non-steroidal Anti-inflammatory Drug-induced Gastric Lesions
[作者:Namba, T; Hoshino, T; Suemasu, S; Takarada-Iemata, M; Hori, O; Nakagata, N; Yanaka, A; Mizushima, T,期刊:Journal of Biological Chemistry, 页码:37302-37313 , 文章类型: Article,,卷期:2010年285-48]
- Both the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, and infection with Helicobacter pylori are major causes of gastric ulcers. Although some clinical studies suggest that infection with ...
- Nuclear Import Mechanism for Myocardin Family Members and Their Correlation with Vascular Smooth Muscle Cell Phenotype
[作者:Nakamura, S; Hayashi, K; Iwasaki, K; Fujioka, T; Egusa, H; Yatani, H; Sobue, K,期刊:Journal of Biological Chemistry, 页码:37314-37323 , 文章类型: Article,,卷期:2010年285-48]
- Myocardin (IMycd), which is essential for the differentiation of the smooth muscle cell lineage, is constitutively located in the nucleus, although its family members, myocardin-related transcription factors A and B (MRT...
- Identification of Key Functional Residues in the Active Site of Human beta 1, 4-Galactosyltransferase 7 A MAJOR ENZYME IN THE GLYCOSAMINOGLYCAN SYNTHESIS PATHWAY
[作者:Talhaoui, I; Bui, C; Oriol, R; Mulliert, G; Gulberti, S; Netter, P; Coughtrie, MWH; Ouzzine, M; Fournel-Gigleux, S,期刊:Journal of Biological Chemistry, 页码:37342-37358 , 文章类型: Article,,卷期:2010年285-48]
- Glycosaminoglycans (GAGs) play a central role in many pathophysiological events, and exogenous xyloside substrates of beta 1,4-galactosyltransferase 7 (beta 4GalT7), a major enzyme of GAG biosynthesis, have interesting b...
- Ca2+ Overload and Sarcoplasmic Reticulum Instability in tric-a Null Skeletal Muscle
[作者:Zhao, XL; Yamazaki, D; Park, KH; Komazaki, S; Tjondrokoesoemo, A; Nishi, M; Lin, PH; Hirata, Y; Brotto, M; Takeshima, H; Ma, JJ,期刊:Journal of Biological Chemistry, 页码:37370-37376 , 文章类型: Article,,卷期:2010年285-48]
- The sarcoplasmic reticulum (SR) of skeletal muscle contains K+, Cl-, and H+ channels may facilitate charge neutralization during Ca2+ release. Our recent studies have identified trimeric intracellular cation (TRIC) chann...
- Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein
[作者:Boland, B; Smith, DA; Mooney, D; Jung, SS; Walsh, DM; Platt, FM,期刊:Journal of Biological Chemistry, 页码:37415-37426 , 文章类型: Article,,卷期:2010年285-48]
- Alterations in the metabolism of amyloid precursor protein (APP) are believed to play a central role in Alzheimer disease pathogenesis. Burgeoning data indicate that APP is proteolytically processed in endosomal-autophag...
- Receptor Activator of NF-kappa B (RANK) Cytoplasmic IVVY535-538 Motif Plays an Essential Role in Tumor Necrosis Factor-alpha (TNF)-mediated Osteoclastogenesis
[作者:Jules, J; Shi, ZQ; Liu, JZ; Xu, DR; Wang, SQ; Feng, X,期刊:Journal of Biological Chemistry, 页码:37427-37435 , 文章类型: Article,,卷期:2010年285-48]
- Tumor necrosis factor-alpha (TNF) enhances osteoclast formation and activity leading to bone loss in various pathological conditions, but its precise role in osteoclastogenesis remains controversial. Although several gro...
- Golgi Calcium Pump Secretory Pathway Calcium ATPase 1 (SPCA1) Is a Key Regulator of Insulin-like Growth Factor Receptor (IGF1R) Processing in the Basal-like Breast Cancer Cell Line MDA-MB-231
[作者:Grice, DM; Vetter, I; Faddy, HM; Kenny, PA; Roberts-Thomson, SJ; Monteith, GR,期刊:Journal of Biological Chemistry, 页码:37458-37466 , 文章类型: Article,,卷期:2010年285-48]
- Calcium signaling is a key regulator of pathways important in tumor progression, such as proliferation and apoptosis. Most studies assessing altered calcium homeostasis in cancer cells have focused on alterations mediate...
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