- Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase
[作者:Cui, HQ; Ruda, GF; Carrero-Lerida, J; Ruiz-Perez, LM; Gilbert, IH; Gonzalez-Pacanowska, D,期刊:European Journal of Medicinal Chemistry, 页码:5140-5149 , 文章类型: Article,,卷期:2010年45-11]
- Plasmodium falciparum purine nucleoside phosphorylase (PfPNP) has a central role in purine salvage and inhibitors of the enzyme have been shown to have antiplasmodial activity. The enzyme preferentially uses inosine as s...
- Synthesis and anti-inflammatory activity of derivatives of coumarino-lignoid, cleomiscosin A and its methyl ether
[作者:Sharma, S; Chattopadhyay, SK; Trivedi, P; Bawankule, DU,期刊:European Journal of Medicinal Chemistry, 页码:5150-5156 , 文章类型: Article,,卷期:2010年45-11]
- Six novel cleomiscosin A (a coumarino-lignoid), derivatives have been synthesized for the first time by using electrophilic substitution reaction to give nuclear nitrated and halogenated derivatives of cleomiscosin A in ...
- [Cyclopentadienyl]metalcarbonyl complexes of acetylsalicylic acid as neo-anticancer agents
[作者:Rubner, G; Bensdorf, K; Wellner, A; Bergemann, S; Ott, I; Gust, R,期刊:European Journal of Medicinal Chemistry, 页码:5157-5163 , 文章类型: Article,,卷期:2010年45-11]
- [(Prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS), a derivative of the nonsteroidal anti-inflammatory drug aspirin (R) (ASS), demonstrated high cytotoxic potential against various tumor cells. The [acetylene...
- Synthesis and antituberculosis activity of some new pyridazine derivatives. Part II
[作者:Mantu, D; Luca, MC; Moldoveanu, C; Zbancioc, G; Mangalagiu, II,期刊:European Journal of Medicinal Chemistry, 页码:5164-5168 , 文章类型: Article,,卷期:2010年45-11]
- A series of eighteen novel compounds with pyridazine moiety were synthesized and their in vitro antituberculosis activities have been evaluated. A fast, general, and facile method for preparation of pyridazine derivative...
- DNA binding, antioxidant and antimicrobial activities of homo- and heteronuclear copper(II) and nickel(II) complexes with new oxime-type ligands
[作者:Colak, A; Terzi, U; Col, M; Karaoglu, SA; Karabocek, S; Kucukdumlu, A; Ayaz, FA,期刊:European Journal of Medicinal Chemistry, 页码:5169-5175 , 文章类型: Article,,卷期:2010年45-11]
- Some homo- and heteronuclear Cu(II) and Ni(II) complexes of new oxime-type ligands were tested against several pathogenic microorganisms to assess their antimicrobial potentials. The antimicrobial activities of complexes...
- QSAR modeling, synthesis and bioassay of diverse leukemia RPMI-8226 cell line active agents
[作者:Katritzky, AR; Girgis, AS; Slavov, S; Tala, SR; Stoyanova-Slavova, I,期刊:European Journal of Medicinal Chemistry, 页码:5183-5199 , 文章类型: Article,,卷期:2010年45-11]
- A rigorous QSAR modeling procedure employing CODESSA PRO descriptors has been utilized for the prediction of more efficient anti-leukemia agents. Experimental data concerning the effect on leukemia RPMI-8226 cell line tu...
- Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives
[作者:Khan, I; Ali, S; Hameed, S; Rama, NH; Hussain, MT; Wadood, A; Uddin, R; Ul-Haq, Z; Khan, A; Ali, S; Choudhary, MI,期刊:European Journal of Medicinal Chemistry, 页码:5200-5207 , 文章类型: Article,,卷期:2010年45-11]
- New series of 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazole-3-thiones (8a-j) and 2,5-disubstituted-1,3,4-thiadiazoles (9a-h) were synthesized by dehydrative cyclization of hydrazinecarbothioamide derivatives (7a-k) by ...
- Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines
[作者:Myadaraboina, S; Alla, M; Saddanapu, V; Bommena, VR; Addlagatta, A,期刊:European Journal of Medicinal Chemistry, 页码:5208-5216 , 文章类型: Article,,卷期:2010年45-11]
- Designed novel imidazo[1,2-a]pyrazine based inhibitors, synthesized by condensing alpha-aminopyrazines with alpha-halocarbonyl compounds followed by electrophilic substitutions. Cytotoxic effects on four cancer cell line...
- Use of phosphonyl carbanions in the synthesis of anti-inflammatory active phosphorus-containing fused heterocycles and relevance phosphonates
[作者:Abdou, WM; Kamel, AA; Shaddy, AA,期刊:European Journal of Medicinal Chemistry, 页码:5217-5224 , 文章类型: Article,,卷期:2010年45-11]
- The reaction of Horner Emmons reactant carbanions with 2-acetyl-5-methyl furan 1 and 2-acetyl-5-bromothiophene 9 resulted in phosphorus-containing fused bicyclic 5,5-membered and 5,6-membered systems 5a-c and 12a-c, resp...
- Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives
[作者:Manjunatha, K; Poojary, B; Lobo, PL; Fernandes, J; Kumari, NS,期刊:European Journal of Medicinal Chemistry, 页码:5225-5233 , 文章类型: Article,,卷期:2010年45-11]
- The acid hydrazides (2) derived from ibuprofen and 4-methylthiophenyl acetic acids have been subjected to cyclization with carbon disulphide under basic conditions to yield 1,3,4-oxadiazol-2-thiones (3) which on aminomet...
- Studies on quinones. Part 46. Synthesis and in vitro antitumor evaluation of aminopyrimidoisoquinolinequinones
[作者:Vasquez, D; Rodriguez, JA; Theoduloz, C; Calderon, PB; Valderrama, JA,期刊:European Journal of Medicinal Chemistry, 页码:5234-5242 , 文章类型: Article,,卷期:2010年45-11]
- In the search of structure-activity relationship studies and to explore the antitumor effect associated with the pyrimidoisoquinolinequinone scaffold, several diversily substituted 8-aminopyrimido[4,5-c] isoquinolinequin...
- Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents
[作者:Hilmy, KMH; Khalifa, MMA; Hawata, MA; Keshk, RMA; El-Torgman, A,期刊:European Journal of Medicinal Chemistry, 页码:5243-5250 , 文章类型: Article,,卷期:2010年45-11]
- A series of new pyrrole derivatives, pyrrolo[2,3-d]pyrimidine derivatives, pyrrolotriazolopyrimidines and pyrrolotetrazolopyrimidines were synthesized. The evaluation of their antimicrobial activities against Staphylococ...
- Synthesis, characterization and antimicrobial activity of some disubstituted 1,3,4-oxadiazoles carrying 2-(aryloxymethyl)phenyl moiety
[作者:Naveena, CS; Boja, P; Kumari, NS,期刊:European Journal of Medicinal Chemistry, 页码:4708-4719 , 文章类型: Article,,卷期:2010年45-11]
- Disubstituted 1,3,4-oxadaiazoles (4a-z, 4a'-f'), Mannich bases (6a-p) and S-alkylated derivatives (7a-t) have been synthesized from 2-(aryloxymethyl)benzoic acids (1a-d) through a multi-step reaction sequence. The struct...
- Synthesis and cytotoxicity evaluation of 1-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]-3-aryl-1H-pyrazole-5-carboxylic acid derivatives
[作者:Nagarapu, L; Gaikwad, HK; Sarikonda, K; Mateti, J; Bantu, R; Raghu, PS; Manda, KM; Kalvendi, SV,期刊:European Journal of Medicinal Chemistry, 页码:4720-4725 , 文章类型: Article,,卷期:2010年45-11]
- Several novel molecules, 1-(3'-(9H-carbazol-4-yloxy)-2'-hydroxypropyl)-3-aryl-1H-pyrazole-5-carboxylic acid derivatives 3a-g were synthesized and screened to evaluate their cytotoxicity against cancer cells in vitro. The...
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