- Structural insight into the mechanisms of enveloped virus tethering by tetherin
[作者:Yang, HT; Wang, JM; Jia, XF; McNatt, MW; Zang, T; Pan, BC; Meng, WY; Wang, HW; Bieniasz, PD; Xiong, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18428-18432 , 文章类型: Article,,卷期:2010年107-43]
- Tetherin/BST2 is a type-II membrane protein that inhibits the release of a range of enveloped viruses, including HIV-1. Here we report three crystal structures of human tetherin, including the full-length ectodomain, a t...
- Clostridium thermocellum cellulosomal genes are regulated by extracytoplasmic polysaccharides via alternative sigma factors
[作者:Nataf, Y; Bahari, L; Kahel-Raifer, H; Borovok, I; Lamed, R; Bayer, EA; Sonenshein, AL; Shoham, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18646-18651 , 文章类型: Article,,卷期:2010年107-43]
- Clostridium thermocellum produces a highly efficient cellulolytic extracellular complex, termed the cellulosome, for hydrolyzing plant cell wall biomass. The composition of the cellulosome is affected by the presence of ...
- Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus
[作者:Trask, SD; Taraporewala, ZF; Boehme, KW; Dermody, TS; Patton, JT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18652-18657 , 文章类型: Article,,卷期:2010年107-43]
- Current methods for engineering the segmented double-stranded RNA genome of rotavirus (RV) are limited by inefficient recovery of the recombinant virus. In an effort to expand the utility of RV reverse genetics, we devel...
- ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis
[作者:Ohno, Y; Suto, S; Yamanaka, M; Mizutani, Y; Mitsutake, S; Igarashi, Y; Sassa, T; Kihara, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18439-18444 , 文章类型: Article,,卷期:2010年107-43]
- Very long-chain fatty acids (VLCFAs) exert a variety of cellular functions and are associated with numerous diseases. However, the precise pathway behind their elongation has remained elusive. Moreover, few regulatory me...
- Light at night increases body mass by shifting the time of food intake
[作者:Fonken, LK; Workman, JL; Walton, JC; Weil, ZM; Morris, JS; Haim, A; Nelson, RJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18664-18669 , 文章类型: Article,,卷期:2010年107-43]
- The global increase in the prevalence of obesity and metabolic disorders coincides with the increase of exposure to light at night (LAN) and shift work. Circadian regulation of energy homeostasis is controlled by an endo...
- Unfolding free energy of a two-domain transmembrane sugar transport protein
[作者:Findlay, HE; Rutherford, NG; Henderson, PJF; Booth, PJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18451-18456 , 文章类型: Article,,卷期:2010年107-43]
- Understanding how an amino acid sequence folds into a functional, three-dimensional structure has proved to be a formidable challenge in biological research, especially for transmembrane proteins with multiple alpha heli...
- Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
[作者:Du, H; Guo, L; Yan, SQ; Sosunov, AA; McKhann, GM; Yan, SS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18670-18675 , 文章类型: Article,,卷期:2010年107-43]
- Synaptic dysfunction and the loss of synapses are early pathological features of Alzheimer's disease (AD). Synapses are sites of high energy demand and extensive calcium fluctuations; accordingly, synaptic transmission r...
- Direct involvement of sigma-1 receptors in the dopamine D-1 receptor-mediated effects of cocaine
[作者:Navarro, G; Moreno, E; Aymerich, M; Marcellino, D; McCormick, PJ; Mallol, J; Cortes, A; Casado, V; Canela, EI; Ortiz, J; Fuxe, K; Lluis, C; Ferre, S; Franco, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18676-18681 , 文章类型: Article,,卷期:2010年107-43]
- It is well known that cocaine blocks the dopamine transporter. This mechanism should lead to a general increase in dopaminergic neurotransmission, and yet dopamine D-1 receptors (D(1)Rs) play a more significant role in t...
- Role of the synaptobrevin C terminus in fusion pore formation
[作者:Ngatchou, AN; Kisler, K; Fang, QH; Walter, AM; Zhao, Y; Bruns, D; Sorensen, JB; Lindau, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18463-18468 , 文章类型: Article,,卷期:2010年107-43]
- Neurotransmitter release is mediated by the SNARE proteins synaptobrevin II (sybII, also known as VAMP2), syntaxin, and SNAP-25, generating a force transfer to the membranes and inducing fusion pore formation. However, t...
- Initiation of the proton pump of cytochrome c oxidase
[作者:Belevich, I; Gorbikova, E; Belevich, NP; Rauhamaki, V; Wikstrom, M; Verkhovsky, MI,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18469-18474 , 文章类型: Article,,卷期:2010年107-43]
- Cytochrome c oxidase is the terminal enzyme of the respiratory chain that is responsible for biological energy conversion in mitochondria and aerobic bacteria. The membrane-bound enzyme converts free energy from oxygen r...
- Neurophysiological origin of human brain asymmetry for speech and language
[作者:Morillon, B; Lehongre, K; Frackowiak, RSJ; Ducorps, A; Kleinschmidt, A; Poeppel, D; Giraud, AL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18688-18693 , 文章类型: Article,,卷期:2010年107-43]
- The physiological basis of human cerebral asymmetry for language remains mysterious. We have used simultaneous physiological and anatomical measurements to investigate the issue. Concentrating on neural oscillatory activ...
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