- Identification of a Pentatricopeptide Repeat Protein Implicated in Splicing of Intron 1 of Mitochondrial nad7 Transcripts
[作者:Koprivova, A; des Francs-Small, CC; Calder, G; Mugford, ST; Tanz, S; Lee, BR; Zechmann, B; Small, I; Kopriva, S,期刊:Journal of Biological Chemistry, 页码:32192-32199 , 文章类型: Article,,卷期:2010年285-42]
- Splicing of plant organellar transcripts is facilitated by members of a large protein family, the pentatricopeptide repeat proteins. We have identified a pentatricopeptide repeat protein in a genetic screen for mutants r...
- Yeast 18 S rRNA Is Directly Involved in the Ribosomal Response to Stringent AUG Selection during Translation Initiation
[作者:Nemoto, N; Singh, CR; Udagawa, T; Wang, SZ; Thorson, E; Winter, Z; Ohira, T; Ii, M; Valasek, L; Brown, SJ; Asano, K,期刊:Journal of Biological Chemistry, 页码:32200-32212 , 文章类型: Article,,卷期:2010年285-42]
- In eukaryotes, the 40 S ribosomal subunit serves as the platform of initiation factor assembly, to place itself precisely on the AUG start codon. Structural arrangement of the 18 S rRNA determines the overall shape of th...
- Mapping the Catalytic Cycle of Schistosoma mansoni Thioredoxin Glutathione Reductase by X-ray Crystallography
[作者:Angelucci, F; Dimastrogiovanni, D; Boumis, G; Brunori, M; Miele, AE; Saccoccia, F; Bellelli, A,期刊:Journal of Biological Chemistry, 页码:32557-32567 , 文章类型: Article,,卷期:2010年285-42]
- Schistosomiasis is the second most widespread human parasitic disease. It is principally treated with one drug, praziquantel, that is administered to 100 million people each year; less sensitive strains of schistosomes a...
- An Order-Disorder Transition Plays a Role in Switching Off the Root Effect in Fish Hemoglobins
[作者:Vergara, A; Vitagliano, L; Merlino, A; Sica, F; Marino, K; Verde, C; di Prisco, G; Mazzarella, L,期刊:Journal of Biological Chemistry, 页码:32568-32575 , 文章类型: Article,,卷期:2010年285-42]
- The Root effect is a widespread property among fish hemoglobins whose structural basis remains largely obscure. Here we report a crystallographic and spectroscopic characterization of the non-Root-effect hemoglobin isola...
- A Novel Pax-like Protein Involved in Transcriptional Activation of Cyst Wall Protein Genes in Giardia lamblia
[作者:Wang, YT; Pan, YJ; Cho, CC; Lin, BC; Su, LH; Huang, YC; Sun, CH,期刊:Journal of Biological Chemistry, 页码:32213-32226 , 文章类型: Article,,卷期:2010年285-42]
- Giardia lamblia differentiates into infectious cysts to survive outside of the host. It is of interest to identify factors involved in up-regulation of cyst wall proteins (CWPs) during this differentiation. Pax proteins ...
- The Cystic Fibrosis Transmembrane Conductance Regulator Impedes Proteolytic Stimulation of the Epithelial Na+ Channel
[作者:Gentzsch, M; Dang, H; Dang, Y; Garcia-Caballero, A; Suchindran, H; Boucher, RC; Stutts, MJ,期刊:Journal of Biological Chemistry, 页码:32227-32232 , 文章类型: Article,,卷期:2010年285-42]
- Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) that prevent its proper folding and trafficking to the apical membrane of epithelial cells. Absence of cAMP-mediated Cl- se...
- Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase
[作者:Dong, HP; Liu, LH; Zou, G; Zhao, YW; Li, Z; Lim, SP; Shi, PY; Li, HM,期刊:Journal of Biological Chemistry, 页码:32586-32595 , 文章类型: Article,,卷期:2010年285-42]
- The flavivirus methyltransferase (MTase) sequentially methylates the N7 and 2'-O positions of the viral RNA cap (GpppA-RNA -> m(7)GpppA-RNA -> m(7)GpppAm-RNA), using S-adenosyl-L-methionine (AdoMet) as a methyl donor. We...
- Novel Oncogenic Mutations of CBL in Human Acute Myeloid Leukemia That Activate Growth and Survival Pathways Depend on Increased Metabolism
[作者:Fernandes, MS; Reddy, MM; Croteau, NJ; Walz, C; Weisbach, H; Podar, K; Band, H; Carroll, M; Reiter, A; Larson, RA; Salgia, R; Griffin, JD; Sattler, M,期刊:Journal of Biological Chemistry, 页码:32596-32605 , 文章类型: Article,,卷期:2010年285-42]
- Acute myeloid leukemia (AML) is characterized by multiple mutagenic events that affect proliferation, survival, as well as differentiation. Recently, gain-of-function mutations in the alpha helical structure within the l...
- Mapping Surface Accessibility of the C1r/C1s Tetramer by Chemical Modification and Mass Spectrometry Provides New Insights into Assembly of the Human C1 Complex
[作者:Brier, S; Pflieger, D; Le Mignon, M; Bally, I; Gaboriaud, C; Arlaud, GJ; Daniel, R,期刊:Journal of Biological Chemistry, 页码:32251-32263 , 文章类型: Article,,卷期:2010年285-42]
- C1, the complex that triggers the classic pathway of complement, is a 790-kDa assembly resulting from association of a recognition protein C1q with a Ca2+-dependent tetramer comprising two copies of the proteases C1r and...
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