- A Novel Cytoplasmic Adaptor for Retinoic Acid Receptor (RAR) and Thyroid Receptor Functions as a Derepressor of RAR in the Absence of Retinoic Acid
[作者:Park, UH; Kim, EJ; Um, SJ,期刊:Journal of Biological Chemistry, 页码:34269-34278 , 文章类型: Article,,卷期:2010年285-44]
- In most mammalian cells, the retinoic acid receptor (RAR) is nuclear rather than cytoplasmic, regardless of its cognate ligand, retinoic acid (RA). In testis Sertoli cells, however, RAR is retained in the cytoplasm and m...
- Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability
[作者:Rampersad, SN; Ovens, JD; Huston, E; Umana, MB; Wilson, LS; Netherton, SJ; Lynch, MJ; Baillie, GS; Houslay, MD; Maurice, DH,期刊:Journal of Biological Chemistry, 页码:33614-33622 , 文章类型: Article,,卷期:2010年285-44]
- Vascular endothelial cell (VEC) permeability is largely dependent on the integrity of vascular endothelial cadherin (VE-cadherin or VE-Cad)-based intercellular adhesions. Activators of protein kinase A (PKA) or of exchan...
- Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion
[作者:Wijesekara, N; Krishnamurthy, M; Bhattacharjee, A; Suhail, A; Sweeney, G; Wheeler, MB,期刊:Journal of Biological Chemistry, 页码:33623-33631 , 文章类型: Article,,卷期:2010年285-44]
- The functional impact of adiponectin on pancreatic beta cells is so far poorly understood. Although adiponectin receptors (AdipoR1/2) were identified, their involvement in adiponectin-induced signaling and other molecule...
- Vacuolar Cation/H+ Antiporters of Saccharomyces cerevisiae
[作者:Cagnac, O; Aranda-Sicilia, MN; Leterrier, M; Rodriguez-Rosales, MP; Venema, K,期刊:Journal of Biological Chemistry, 页码:33914-33922 , 文章类型: Article,,卷期:2010年285-44]
- We previously demonstrated that Saccharomyces cerevisiae vnx1 Delta mutant strains displayed an almost total loss of Na+ and K+/H+ antiporter activity in a vacuole-enriched fraction. However, using different in vitro tra...
- ATP-dependent Mechanism Protects Spectrin against Glycation in Human Erythrocytes
[作者:Manno, S; Mohandas, N; Takakuwa, Y,期刊:Journal of Biological Chemistry, 页码:33923-33929 , 文章类型: Article,,卷期:2010年285-44]
- Human erythrocytes are continuously exposed to glucose, which reacts with the amino terminus of the beta-chain of hemoglobin (Hb) to form glycated Hb, HbA1c, levels of which increase with the age of the circulating cell....
- Calmodulin Suppresses Synaptotagmin-2 Transcription in Cortical Neurons
[作者:Pang, ZP; Xu, W; Cao, P; Sudhof, TC,期刊:Journal of Biological Chemistry, 页码:33930-33939 , 文章类型: Article,,卷期:2010年285-44]
- Calmodulin (CaM) is a ubiquitous Ca2+ sensor protein that plays a pivotal role in regulating innumerable neuronal functions, including synaptic transmission. In cortical neurons, most neurotransmitter release is triggere...
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