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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共83条记录   Mutational Analysis of Saccharomyces cerevisiae Erf2 Reveals a Two-step Reaction Mechanism for Protein Palmitoylation by DHHC Enzymes [作者：Mitchell, DA; Mitchell, G; Ling, YP; Budde, C; Deschenes, RJ,期刊：Journal of Biological Chemistry, 页码：38104-38114 , 文章类型： Article，,卷期：2010年285-49] DHHC protein acyltransferases (PATs) catalyze the palmitoylation of eukaryotic proteins through an enzymatic mechanism that remains largely unexplored. In this study we have combined genetic and biochemical approaches to... Ablation of Skeletal Muscle Triadin Impairs FKBP12/RyR1 Channel Interactions Essential for Maintaining Resting Cytoplasmic Ca2+ [作者：Eltit, JM; Feng, W; Lopez, JR; Padilla, IT; Pessah, IN; Molinski, TF; Fruen, BR; Allen, PD; Perez, CF,期刊：Journal of Biological Chemistry, 页码：38453-38462 , 文章类型： Article，,卷期：2010年285-49] Previously, we have shown that lack of expression of triadins in skeletal muscle cells results in significant increase of myoplasmic resting free Ca2+ ([Ca2+](rest)), suggesting a role for triadins in modulating global i... Sp1-dependent Activation of HDAC7 Is Required for Platelet-derived Growth Factor-BB-induced Smooth Muscle Cell Differentiation from Stem Cells [作者：Zhang, L; Jin, M; Margariti, A; Wang, G; Luo, ZL; Zampetaki, A; Zeng, LF; Ye, S; Zhu, JH; Xiao, QH,期刊：Journal of Biological Chemistry, 页码：38463-38472 , 文章类型： Article，,卷期：2010年285-49] We have previously demonstrated that histone deacetylase 7 (HDAC7) expression and splicing play an important role in smooth muscle cell (SMC) differentiation from embryonic stem (ES) cells, but the molecular mechanism... Cross-linking Chemistry of Squid Beak [作者：Miserez, A; Rubin, D; Waite, JH,期刊：Journal of Biological Chemistry, 页码：38115-38124 , 文章类型： Article，,卷期：2010年285-49] In stark contrast to most aggressive predators, Dosidicus gigas (jumbo squids) do not use minerals in their powerful mouthparts known as beaks. Their beaks instead consist of a highly sclerotized chitinous composite with... Basis for MAP4 Dephosphorylation-related Microtubule Network Densification in Pressure Overload Cardiac Hypertrophy [作者：Cheng, GM; Takahashi, M; Shunmugavel, A; Wallenborn, JG; DePaoli-Roach, AA; Gergs, U; Neumann, J; Kuppuswamy, D; Menick, DR; Cooper, G,期刊：Journal of Biological Chemistry, 页码：38125-38140 , 文章类型： Article，,卷期：2010年285-49] Increased activity of Ser/Thr protein phosphatases types 1 (PP1) and 2A (PP2A) during maladaptive cardiac hypertrophy contributes to cardiac dysfunction and eventual failure, partly through effects on calcium metabolism.... Vesicle Fusion Probability Is Determined by the Specific Interactions of Munc18 [作者：Smyth, AM; Rickman, C; Duncan, RR,期刊：Journal of Biological Chemistry, 页码：38141-38148 , 文章类型： Article，,卷期：2010年285-49] Mammalian-regulated secretion is absolutely dependent on four evolutionarily conserved proteins: three SNARE proteins and munc18. Dissecting the functional outcomes of the spatially organized protein interactions between... Binding of the Human Complement Regulators CFHR1 and Factor H by Streptococcal Collagen-like Protein 1 (Scl1) via Their Conserved C Termini Allows Control of the Complement Cascade at Multiple Levels [作者：Reuter, M; Caswell, CC; Lukomski, S; Zipfel, PF,期刊：Journal of Biological Chemistry, 页码：38473-38485 , 文章类型： Article，,卷期：2010年285-49] Group A streptococci (GAS) utilize soluble human complement regulators to evade host complement attack. Here, we characterized the binding of the terminal complement complex inhibitor complement Factor H-related protein ... Normal and Friedreich Ataxia Cells Express Different Isoforms of Frataxin with Complementary Roles in Iron-Sulfur Cluster Assembly [作者：Gakh, O; Bedekovics, T; Duncan, SF; Smith, DY; Berkholz, DS; Isaya, G,期刊：Journal of Biological Chemistry, 页码：38486-38501 , 文章类型： Article，,卷期：2010年285-49] Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused by insufficient expression of frataxin (FXN), a mitochondrial iron-binding protein required for Fe-S cluster assembly. The development of tre... Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain [作者：Wang, HC; Robinson, H; Ke, HM,期刊：Journal of Biological Chemistry, 页码：38149-38156 , 文章类型： Article，,卷期：2010年285-49] The activity of phosphodiesterase-5 (PDE5) is specific for cGMP and is regulated by cGMP binding to GAF-A in its regulatory domain. To better understand the regulatory mechanism, x-ray crystallographic and biochemical st... New Aminoacyl-tRNA Synthetase-like Protein in Insecta with an Essential Mitochondrial Function [作者：Guitart, T; Bernardo, TL; Sagales, J; Stratmann, T; Bernues, J; de Pouplana, LR,期刊：Journal of Biological Chemistry, 页码：38157-38166 , 文章类型： Article，,卷期：2010年285-49] Aminoacyl-tRNA synthetases (ARS) are modular enzymes that aminoacylate transfer RNAs (tRNA) for their use by the ribosome during protein synthesis. ARS are essential and universal components of the genetic code that were... Full Reconstruction of a Vectorial Protein Folding Pathway by Atomic Force Microscopy and Molecular Dynamics Simulations [作者：Lee, W; Zeng, XC; Zhou, HX; Bennett, V; Yang, WT; Marszalek, PE,期刊：Journal of Biological Chemistry, 页码：38167-38172 , 文章类型： Article，,卷期：2010年285-49] During co-translational folding, the nascent polypeptide chain is extruded sequentially from the ribosome exit tunnel and, under severe conformational constraints, is dictated by its one-dimensional geometry. How do such... The Solution Structure of a Plant Calmodulin and the CaM-binding Domain of the Vacuolar Calcium-ATPase BCA1 Reveals a New Binding and Activation Mechanism [作者：Ishida, H; Vogel, HJ,期刊：Journal of Biological Chemistry, 页码：38502-38510 , 文章类型： Article，,卷期：2010年285-49] The type IIb class of plant Ca2+-ATPases contains a unique N-terminal extension that encompasses a calmodulin (CaM) binding domain and an auto-inhibitory domain. Binding of Ca2+-CaM to this region can release auto-inhibi... An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+ Signals [作者：Brailoiu, E; Rahman, T; Churamani, D; Prole, DL; Brailoiu, GC; Hooper, R; Taylor, CW; Patel, S,期刊：Journal of Biological Chemistry, 页码：38511-38516 , 文章类型： Article，,卷期：2010年285-49] Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous messenger proposed to stimulate Ca2+ release from acidic organelles via two-pore channels (TPCs). It has been difficult to resolve this trigger event ... A Structural Determinant for the Control of PIP2 Sensitivity in G Protein-gated Inward Rectifier K+ Channels [作者：Inanobe, A; Nakagawa, A; Matsuura, T; Kurachi, Y,期刊：Journal of Biological Chemistry, 页码：38517-38523 , 文章类型： Article，,卷期：2010年285-49] Inward rectifier K+ (Kir) channels are activated by phosphatidylinositol-(4,5)-bisphosphate (PIP2), but G protein-gated Kir (K-G) channels further require either G protein beta gamma subunits (G beta gamma) or intracellu... Stable alpha-Synuclein Oligomers Strongly Inhibit Chaperone Activity of the Hsp70 System by Weak Interactions with J-domain Co-chaperones [作者：Hinault, MP; Cuendet, AFH; Mattoo, RUH; Mensi, M; Dietler, G; Lashuel, HA; Goloubinoff, P,期刊：Journal of Biological Chemistry, 页码：38173-38182 , 文章类型： Article，,卷期：2010年285-49] alpha-Synuclein aggregation and accumulation in Lewy bodies are implicated in progressive loss of dopaminergic neurons in Parkinson disease and related disorders. In neurons, the Hsp70s and their Hsp40-like J-domain co-c... Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle [作者：Lotz, GP; Legleiter, J; Aron, R; Mitchell, EJ; Huang, SY; Ng, CP; Glabe, C; Thompson, LM; Muchowski, PJ,期刊：Journal of Biological Chemistry, 页码：38183-38193 , 文章类型： Article，,卷期：2010年285-49] Inclusion bodies of aggregated mutant huntingtin (htt) fragments are a neuropathological hallmark of Huntington disease (HD). The molecular chaperones Hsp70 and Hsp40 colocalize to inclusion bodies and are neuroprotectiv...