- Nicotine response genetics in the zebrafish
[作者:Petzold, AM; Balciunas, D; Sivasubbu, S; Clark, KJ; Bedell, VM; Westcot, SE; Myers, SR; Moulder, GL; Thomas, MJ; Ekker, SC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18662-18667 , 文章类型: Article,,卷期:2009年106-44]
- Tobacco use is predicted to result in over 1 billion deaths worldwide by the end of the 21(st) century. How genetic variation contributes to the observed differential predisposition in the human population to drug depend...
- 26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans
[作者:Han, T; Manoharan, AP; Harkins, TT; Bouffard, P; Fitzpatrick, C; Chu, DS; Thierry-Mieg, D; Thierry-Mieg, J; Kim, JK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18674-18679 , 文章类型: Article,,卷期:2009年106-44]
- Endogenous small interfering RNAs (endo-siRNAs) regulate diverse gene expression programs in eukaryotes by either binding and cleaving mRNA targets or mediating heterochromatin formation; however, the mechanisms of endo-...
- Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
[作者:Rioux, JD; Goyette, P; Vyse, TJ; Hammarstrom, L; Fernando, MMA; Green, T; De Jager, PL; Foisy, S; Wang, J; de Bakker, PIW; Leslie, S; McVean, G; Padyukov, L; Alfredsson, L; Annese, V; Hafler, DA; Pan-Hammarstrom, Q; Matell, R; Sawcer, SJ; Compston, AD; Cree, BAC; Mirel, DB; Daly, MJ; Behrens, TW; Klareskog, L; Gregersen, PK; Oksenberg, JR; Hauser, SL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18680-18685 , 文章类型: Article,,卷期:2009年106-44]
- The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predisposing gene(s) has been handicapped by the strong linkage disequilibrium across the regio...
- Nanoparticle-based bio-barcode assay redefines "undetectable'' PSA and biochemical recurrence after radical prostatectomy
[作者:Thaxton, CS; Elghanian, R; Thomas, AD; Stoeva, SI; Lee, JS; Smith, ND; Schaeffer, AJ; Klocker, H; Horninger, W; Bartsch, G; Mirkin, CA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18437-18442 , 文章类型: Article,,卷期:2009年106-44]
- We report the development of a previously undescribed gold nanoparticle bio-barcode assay probe for the detection of prostate specific antigen (PSA) at 330 fg/mL, automation of the assay, and the results of a clinical pi...
- Nitrogen management is essential to prevent tropical oil palm plantations from causing ground-level ozone pollution
[作者:Hewitt, CN; MacKenzie, AR; Di Carlo, P; Di Marco, CF; Dorsey, JR; Evans, M; Fowler, D; Gallagher, MW; Hopkins, JR; Jones, CE; Langford, B; Lee, JD; Lewis, AC; Lim, SF; McQuaid, J; Misztal, P; Moller, SJ; Monks, PS; Nemitz, E; Oram, DE; Owen, SM; Phillips, GJ; Pugh, TAM; Pyle, JA; Reeves, CE; Ryder, J; Siong, J; Skiba, U; Stewart, DJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18447-18451 , 文章类型: Article,,卷期:2009年106-44]
- More than half the world's rainforest has been lost to agriculture since the Industrial Revolution. Among the most widespread tropical crops is oil palm (Elaeis guineensis): global production now exceeds 35 million tonne...
- Long-lived states to sustain hyperpolarized magnetization
[作者:Vasos, PR; Comment, A; Sarkar, R; Ahuja, P; Jannin, S; Ansermet, JP; Konter, JA; Hautle, P; van den Brandt, B; Bodenhausen, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18469-18473 , 文章类型: Article,,卷期:2009年106-44]
- Major breakthroughs have recently been reported that can help overcome two inherent drawbacks of NMR: the lack of sensitivity and the limited memory of longitudinal magnetization. Dynamic nuclear polarization (DNP) coupl...
- X-ray structure of Pur-alpha reveals a Whirly-like fold and an unusual nucleic-acid binding surface
[作者:Graebsch, A; Roche, S; Niessing, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18521-18526 , 文章类型: Article,,卷期:2009年106-44]
- The PUR protein family is a distinct and highly conserved class that is characterized by its sequence-specific RNA-and DNA-binding. Its best-studied family member, Pur-alpha, acts as a transcriptional regulator, as host ...
- Hotspots of GPI-anchored proteins and integrin nanoclusters function as nucleation sites for cell adhesion
[作者:van Zanten, TS; Cambi, A; Koopman, M; Joosten, B; Figdor, CG; Garcia-Parajo, MF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18557-18562 , 文章类型: Article,,卷期:2009年106-44]
- Recruitment of receptor proteins to lipid rafts has been proposed as an important mechanism to regulate their cellular function. In particular, rafts have been implicated in regulation of integrin-mediated cell adhesion,...
- Priming integrin alpha 5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis
[作者:Hamidouche, Z; Fromigue, O; Ringe, J; Haupl, T; Vaudin, P; Pages, JC; Srouji, S; Livne, E; Marie, PJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18587-18591 , 文章类型: Article,,卷期:2009年106-44]
- Adult human mesenchymal stromal cells (hMSCs) have the potential to differentiate into chondrogenic, adipogenic, or osteogenic lineages, providing a potential source for tissue regeneration. An important issue for effici...
- Late Paleocene fossils from the Cerrejon Formation, Colombia, are the earliest record of Neotropical rainforest
[作者:Wing, SL; Herrera, F; Jaramillo, CA; Gomez-Navarro, C; Wilf, P; Labandeira, CC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18627-18632 , 文章类型: Article,,卷期:2009年106-44]
- Neotropical rainforests have a very poor fossil record, making hypotheses concerning their origins difficult to evaluate. Nevertheless, some of their most important characteristics can be preserved in the fossil record: ...
- Resolving the evolution of extant and extinct ruminants with high-throughput phylogenomics
[作者:Decker, JE; Pires, JC; Conant, GC; Mckay, SD; Heaton, MP; Chen, KF; Cooper, A; Vilkki, J; Seabury, CM; Caetano, AR; Johnson, GS; Brenneman, RA; Hanotte, O; Eggert, LS; Wiener, P; Kim, JJ; Kim, KS; Sonstegard, TS; Van Tassell, CP; Neibergs, HL; McEwan, JC; Brauning, R; Coutinho, LL; Babar, ME; Wilson, GA; McClure, MC; Rolf, MM; Kim, J; Schnabel, RD; Taylor, JF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18644-18649 , 文章类型: Article,,卷期:2009年106-44]
- The Pecorans (higher ruminants) are believed to have rapidly speciated in the Mid-Eocene, resulting in five distinct extant families: Antilocapridae, Giraffidae, Moschidae, Cervidae, and Bovidae. Due to the rapid radiati...
- Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection
[作者:Helenius, IT; Krupinski, T; Turnbull, DW; Gruenbaum, Y; Silverman, N; Johnson, EA; Sporn, PHS; Sznajder, JI; Beitel, GJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18710-18715 , 文章类型: Article,,卷期:2009年106-44]
- Elevated CO2 levels (hypercapnia) frequently occur in patients with obstructive pulmonary diseases and are associated with increased mortality. However, the effects of hypercapnia on non-neuronal tissues and the mechanis...
- Interaction of malaria with a common form of severe thalassemia in an Asian population
[作者:O'Donnell, A; Premawardhena, A; Arambepola, M; Samaranayake, R; Allen, SJ; Peto, TEA; Fisher, CA; Cook, J; Corran, PH; Olivieri, NF; Weatherall, DJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18716-18721 , 文章类型: Article,,卷期:2009年106-44]
- In many Asian populations, the commonest form of severe thalassemia results from the coinheritance of HbE and beta thalassemia. The management of this disease is particularly difficult because of its extreme clinical div...
- Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2
[作者:Hasumi, Y; Baba, M; Ajima, R; Hasumi, H; Valera, VA; Klein, ME; Haines, DC; Merino, MJ; Hong, SB; Yamaguchi, TP; Schmidt, LS; Linehan, WM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18722-18727 , 文章类型: Article,,卷期:2009年106-44]
- Germline mutations in the BHD/FLCN tumor suppressor gene predispose patients to develop renal tumors in the hamartoma syndrome, Birt-Hogg-Dube (BHD). BHD encodes folliculin, a protein with unknown function that may inter...
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