- Photoactivation mechanism of PAmCherry based on crystal structures of the protein in the dark and fluorescent states
[作者:Subach, FV; Malashkevich, VN; Zencheck, WD; Xiao, H; Filonov, GS; Almo, SC; Verkhusha, VV,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21097-21102 , 文章类型: Article,,卷期:2009年106-50]
- Photoactivatable fluorescent proteins (PAFPs) are required for super-resolution imaging of live cells. Recently, the first red PAFP, PAmCherry1, was reported, which complements the photo-activatable GFP by providing a re...
- Structural insights into tail-anchored protein binding and membrane insertion by Get3
[作者:Bozkurt, G; Stjepanovic, G; Vilardi, F; Amlacher, S; Wild, K; Bange, G; Favaloro, V; Rippe, K; Hurt, E; Dobberstein, B; Sinning, I,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21131-21136 , 文章类型: Article,,卷期:2009年106-50]
- Tail-anchored (TA) membrane proteins are involved in a variety of important cellular functions, including membrane fusion, protein translocation, and apoptosis. The ATPase Get3 (Asna1, TRC40) was identified recently as t...
- Phytoplankton, not allochthonous carbon, sustains herbivorous zooplankton production
[作者:Brett, MT; Kainz, MJ; Taipale, SJ; Seshan, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21197-21201 , 文章类型: Article,,卷期:2009年106-50]
- Terrestrial organic matter inputs have long been thought to play an important role in aquatic food web dynamics. Results from recent whole lake C-13 addition experiments suggest terrestrial particulate organic carbon (t-...
- Bacterial gut symbionts are tightly linked with the evolution of herbivory in ants
[作者:Russell, JA; Moreau, CS; Goldman-Huertas, B; Fujiwara, M; Lohman, DJ; Pierce, NE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21236-21241 , 文章类型: Article,,卷期:2009年106-50]
- Ants are a dominant feature of terrestrial ecosystems, yet we know little about the forces that drive their evolution. Recent findings illustrate that their diets range from herbivorous to predaceous, with "herbivores'' ...
- Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model
[作者:Bernhardt, WM; Gottmann, U; Doyon, F; Buchholz, B; Campean, V; Schodel, J; Reisenbuechler, A; Klaus, S; Arend, M; Flippin, L; Willam, C; Wiesener, MS; Yard, B; Warnecke, C; Eckardt, KU,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21276-21281 , 文章类型: Article,,卷期:2009年106-50]
- Long-term survival of renal allografts depends on the chronic immune response and is probably influenced by the initial injury caused by ischemia and reperfusion. Hypoxia-inducible transcription factors (HIFs) are essent...
- Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis
[作者:Emdad, L; Lee, SG; Su, ZZ; Jeon, HY; Boukerche, H; Sarkar, D; Fisher, PB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21300-21305 , 文章类型: Article,,卷期:2009年106-50]
- Astrocyte-elevated gene-1 (AEG-1) expression is increased in multiple cancers and plays a central role in Ha-ras-mediated oncogenesis through the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Additionally, ...
- Human cancers converge at the HIF-2 alpha oncogenic axis
[作者:Franovic, A; Holterman, CE; Payette, J; Lee, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21306-21311 , 文章类型: Article,,卷期:2009年106-50]
- Cancer development is a multistep process, driven by a series of genetic and environmental alterations, that endows cells with a set of hallmark traits required for tumorigenesis. It is broadly accepted that growth signa...
- Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors
[作者:Ueki, Y; Le, YZ; Chollangi, S; Muller, W; Ash, JD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21389-21394 , 文章类型: Article,,卷期:2009年106-50]
- Retinal degenerations are a class of neurodegenerative disorders that ultimately lead to blindness due to the death of retinal photoreceptors. In most cases, death is the result of long-term exposure to environmental, in...
- EIN3/EIL1 cooperate with PIF1 to prevent photo-oxidation and to promote greening of Arabidopsis seedlings
[作者:Zhong, SW; Zhao, MT; Shi, TY; Shi, H; An, FY; Zhao, Q; Guo, HW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21431-21436 , 文章类型: Article,,卷期:2009年106-50]
- The ability to switch from skotomorphogenesis to photomorphogenesis is essential for seedling development and plant survival. Recent studies revealed that COP1 and phytochrome-interacting factors (PIFs) are key regulator...
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