- The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions
[作者:Bottos, A; Destro, E; Rissone, A; Graziano, S; Cordara, G; Assenzio, B; Cera, MR; Mascia, L; Bussolino, F; Arese, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20782-20787 , 文章类型: Article,,卷期:2009年106-49]
- Unlike other neuronal counterparts, primary synaptic proteins are not known to be involved in vascular physiology. Here, we demonstrate that neurexins and neuroligins, which constitute large and complex families of funda...
- A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization
[作者:Taimen, P; Pfleghaar, K; Shimi, T; Moller, D; Ben-Harush, K; Erdos, MR; Adam, SA; Herrmann, H; Medalia, O; Collins, FS; Goldman, AE; Goldman, RD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20788-20793 , 文章类型: Article,,卷期:2009年106-49]
- Numerous mutations in the human A-type lamin gene (LMNA) cause the premature aging disease, progeria. Some of these are located in the alpha-helical central rod domain required for the polymerization of the nuclear lamin...
- A microRNA regulatory mechanism of osteoblast differentiation
[作者:Inose, H; Ochi, H; Kimura, A; Fujita, K; Xu, R; Sato, S; Iwasaki, M; Sunamura, S; Takeuchi, Y; Fukumoto, S; Saito, K; Nakamura, T; Siomi, H; Ito, H; Arai, Y; Shinomiya, K; Takeda, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20794-20799 , 文章类型: Article,,卷期:2009年106-49]
- Growing evidence shows that microRNAs (miRNAs) regulate various developmental and homeostatic events in vertebrates and invertebrates. Osteoblast differentiation is a key step in proper skeletal development and acquisiti...
- Exploring the likelihood and mechanism of a climate-change-induced dieback of the Amazon rainforest
[作者:Malhi, Y; Aragao, LEOC; Galbraith, D; Huntingford, C; Fisher, R; Zelazowski, P; Sitch, S; McSweeney, C; Meir, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20610-20615 , 文章类型: Article,,卷期:2009年106-49]
- We examine the evidence for the possibility that 21st-century climate change may cause a large-scale "dieback'' or degradation of Amazonian rainforest. We employ a new framework for evaluating the rainfall regime of trop...
- Symbolic gestures and spoken language are processed by a common neural system
[作者:Xua, J; Gannon, PJ; Emmorey, K; Smith, JF; Braun, AR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20664-20669 , 文章类型: Article,,卷期:2009年106-49]
- Symbolic gestures, such as pantomimes that signify actions (e. g., threading a needle) or emblems that facilitate social transactions (e. g., finger to lips indicating "be quiet''), play an important role in human commun...
- Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer
[作者:Huang, F; Rajagopalan, S; Settanni, G; Marsh, RJ; Armoogum, DA; Nicolaou, N; Bain, AJ; Lerner, E; Haas, E; Ying, LM; Fersht, AR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20758-20763 , 文章类型: Article,,卷期:2009年106-49]
- The tumor suppressor p53 is a member of the emerging class of proteins that have both folded and intrinsically disordered domains, which are a challenge to structural biology. Its N-terminal domain (NTD) is linked to a f...
- Phylogenomic analyses reveal convergent patterns of adaptive evolution in elephant and human ancestries
[作者:Goodman, M; Sterner, KN; Islam, M; Uddin, M; Sherwood, CC; Hof, PR; Hou, ZC; Lipovich, L; Jia, H; Grossman, LI; Wildman, DE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20824-20829 , 文章类型: Article,,卷期:2009年106-49]
- Specific sets of brain-expressed genes, such as aerobic energy metabolism genes, evolved adaptively in the ancestry of humans and may have evolved adaptively in the ancestry of other large-brained mammals. The recent add...
- Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
[作者:Saitoh, T; Fujita, N; Hayashi, T; Takahara, K; Satoh, T; Lee, H; Matsunaga, K; Kageyama, S; Omori, H; Noda, T; Yamamoto, N; Kawai, T; Ishii, K; Takeuchi, O; Yoshimori, T; Akira, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20842-20846 , 文章类型: Article,,卷期:2009年106-49]
- Microbial nucleic acids are critical for the induction of innate immune responses, a host defense mechanism against infection by microbes. Recent studies have indicated that double-stranded DNA (dsDNA) induces potent inn...
- Cardiovascular fitness is associated with cognition in young adulthood
[作者:Aberg, MAI; Pedersen, NL; Toren, K; Svartengren, M; Backstrand, B; Johnsson, T; Cooper-Kuhn, CM; Aberg, ND; Nilsson, M; Kuhn, HG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20906-20911 , 文章类型: Article,,卷期:2009年106-49]
- During early adulthood, a phase in which the central nervous system displays considerable plasticity and in which important cognitive traits are shaped, the effects of exercise on cognition remain poorly understood. We p...
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