- Asparagine-linked Oligosaccharides Present on a Non-consensus Amino Acid Sequence in the C(H)1 Domain of Human Antibodies
[作者:Valliere-Douglass, JF; Kodama, P; Mujacic, M; Brady, LJ; Wang, W; Wallace, A; Yan, BX; Reddy, P; Treuheit, MJ; Balland, A,期刊:Journal of Biological Chemistry, 页码:32493-32506 , 文章类型: Article,,卷期:2009年284-47]
- We report that N-linked oligosaccharide structures can be present on an asparagine residue not adhering to the consensus site motif NX(S/T), where X is not proline, described in the literature. We have observed oligosacc...
- Identification and Functional Characterization of ERK/MAPK Phosphorylation Sites in the Runx2 Transcription Factor
[作者:Ge, CX; Xiao, GZ; Jiang, D; Yang, Q; Hatch, NE; Roca, H; Franceschi, RT,期刊:Journal of Biological Chemistry, 页码:32533-32543 , 文章类型: Article,,卷期:2009年284-47]
- The Runx2 transcription factor is required for commitment of mesenchymal cells to bone lineages and is a major regulator of osteoblast-specific gene expression. Runx2 is subject to a number of post-transcriptional contro...
- Myocardin-dependent Activation of the CArG Box-rich Smooth Muscle gamma-Actin Gene PREFERENTIAL UTILIZATION OF A SINGLE CArG ELEMENT THROUGH FUNCTIONAL ASSOCIATION WITH THE NKX3.1 HOMEODOMAIN PROTEIN
[作者:Sun, Q; Taurin, S; Sethakorn, N; Long, XC; Imamura, M; Wang, DZ; Zimmer, WE; Dulin, NO; Miano, JM,期刊:Journal of Biological Chemistry, 页码:32582-32590 , 文章类型: Article,,卷期:2009年284-47]
- Serum response factor (SRF) is a ubiquitously expressed transcription factor that binds a 10-bp element known as the CArG box, located in the proximal regulatory region of hundreds of target genes. SRF activates target g...
- Identification of a New Exosite Involved in Catalytic Turnover by the Streptokinase-Plasmin Activator Complex during Human Plasminogen Activation
[作者:Aneja, R; Datt, M; Singh, B; Kumar, S; Sahni, G,期刊:Journal of Biological Chemistry, 页码:32642-32650 , 文章类型: Article,,卷期:2009年284-47]
- With the goal of identifying hitherto unknown surface exosites of streptokinase involved in substrate human plasminogen recognition and catalytic turnover, synthetic peptides encompassing the 170 loop (CQFTPLNPDDDFRPGLKD...
- GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent L-Asparaginase
[作者:Bunpo, P; Dudley, A; Cundiff, JK; Cavener, DR; Wek, RC; Anthony, TG,期刊:Journal of Biological Chemistry, 页码:32742-32749 , 文章类型: Article,,卷期:2009年284-47]
- Asparaginase depletes circulating asparagine and glutamine, activating amino acid deprivation responses (AADR) such as phosphorylation of eukaryotic initiation factor 2 (p-eIF2) leading to increased mRNA levels of aspara...
- Thymidine Analogue Resistance Suppression by V75I of HIV-1 Reverse Transcriptase EFFECTS OF SUBSTITUTING VALINE 75 ON STAVUDINE EXCISION AND DISCRIMINATION
[作者:Matamoros, T; Nevot, M; Martinez, MA; Menendez-Arias, L,期刊:Journal of Biological Chemistry, 页码:32792-32802 , 文章类型: Article,,卷期:2009年284-47]
- Val(75) of HIV-1 reverse transcriptase (RT) plays a role in positioning the template nucleotide +1 during the formation of the ternary complex. Mutations, such as V75M and V75A, emerge in patients infected with HIV-1 gro...
- A Sporadic Parkinson Disease Model via Silencing of the Ubiquitin-Proteasome/E3 Ligase Component SKP1A
[作者:Fishman-Jacob, T; Reznichenko, L; Youdim, MBH; Mandel, SA,期刊:Journal of Biological Chemistry, 页码:32835-32845 , 文章类型: Article,,卷期:2009年284-47]
- The aim of this study was to develop a new model of sporadic Parkinson disease (PD) based on silencing of the SKP1A gene, a component of the ubiquitin-proteasome/E3 ligase complex, Skp1, Cullin 1, F-box protein, which wa...
- Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid beta-Protein (A beta) Assembly from Alzheimer Disease Brains
[作者:Noguchi, A; Matsumura, S; Dezawa, M; Tada, M; Yanazawa, M; Ito, A; Akioka, M; Kikuchi, S; Sato, M; Ideno, S; Noda, M; Fukunari, A; Muramatsu, S; Itokazu, Y; Sato, K; Takahashi, H; Teplow, DB; Nabeshima, Y; Kakita, A; Imahori, K; Hoshi, M,期刊:Journal of Biological Chemistry, 页码:32895-32905 , 文章类型: Article,,卷期:2009年284-47]
- Amyloid beta-protein (A beta) assemblies are thought to play primary roles in Alzheimer disease (AD). They are considered to acquire surface tertiary structures, not present in physiologic monomers, that are responsible ...
- SAGA and Rpd3 Chromatin Modification Complexes Dynamically Regulate Heat Shock Gene Structure and Expression
[作者:Kremer, SB; Gross, DS,期刊:Journal of Biological Chemistry, 页码:32914-32931 , 文章类型: Article,,卷期:2009年284-47]
- The chromatin structure of heat shock protein (HSP)-encoding genes undergoes dramatic alterations upon transcriptional induction, including, in extreme cases, domain-wide nucleosome disassembly. Here, we use a combinatio...
- ScFv Antibody-induced Translocation of Cell-surface Heparan Sulfate Proteoglycan to Endocytic Vesicles EVIDENCE FOR HEPARAN SULFATE EPITOPE SPECIFICITY AND ROLE OF BOTH SYNDECAN AND GLYPICAN
[作者:Wittrup, A; Zhang, SH; ten Dam, GB; van Kuppevelt, TH; Bengtson, P; Johansson, M; Welch, J; Morgelin, M; Belting, M,期刊:Journal of Biological Chemistry, 页码:32959-32967 , 文章类型: Article,,卷期:2009年284-47]
- Cellular uptake of several viruses and polybasic macromolecules requires the expression of cell-surface heparan sulfate proteoglycan (HSPG) through as yet ill defined mechanisms. We unexpectedly found that among several ...
- ADP Signaling in Vascular Endothelial Cells ADP-DEPENDENT ACTIVATION OF THE ENDOTHELIAL ISOFORM OF NITRIC-OXIDE SYNTHASE REQUIRES THE EXPRESSION BUT NOT THE KINASE ACTIVITY OF AMP-ACTIVATED PROTEIN KINASE
[作者:Hess, CN; Kou, RQ; Johnson, RP; Li, GK; Michel, T,期刊:Journal of Biological Chemistry, 页码:32209-32224 , 文章类型: Article,,卷期:2009年284-47]
- ADP responses underlie therapeutic approaches to many cardiovascular diseases, and ADP receptor antagonists are in widespread clinical use. The role of ADP in platelet biology has been extensively studied, yet ADP signal...
- Phosphatase and Tensin Homologue on Chromosome 10 (PTEN) Directs Prostaglandin E-2-mediated Fibroblast Responses via Regulation of E Prostanoid 2 Receptor Expression
[作者:Sagana, RL; Yan, M; Cornett, AM; Tsui, JL; Stephenson, DA; Huang, SK; Moore, BB; Ballinger, MN; Melonakos, J; Kontos, CD; Aronoff, DM; Peters-Golden, M; White, ES,期刊:Journal of Biological Chemistry, 页码:32264-32271 , 文章类型: Article,,卷期:2009年284-47]
- Prostaglandin E-2 (PGE(2)) is an arachidonic acid metabolite that counters transforming growth factor-beta-induced fibroblast activation via E prostanoid 2 (EP2) receptor binding. Phosphatase and tensin homologue on chro...
- Agonist Dose-dependent Phosphorylation by Protein Kinase A and G Protein-coupled Receptor Kinase Regulates beta(2) Adrenoceptor Coupling to G(i) Proteins in Cardiomyocytes
[作者:Liu, RJ; Ramani, B; Soto, D; De Arcangelis, V; Xiang, Y,期刊:Journal of Biological Chemistry, 页码:32279-32287 , 文章类型: Article,,卷期:2009年284-47]
- Adrenoceptors receptors (ARs) play a pivotal role in regulating cardiovascular response to catecholamines during stress. beta(2)ARs, prototypical G protein-coupled receptors (GPCRs), expressed in animal hearts, display d...
|