- Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation EVIDENCE FOR AN INTRACELLULAR ROUTE
[作者:Poirier, S; Mayer, G; Poupon, V; McPherson, PS; Desjardins, R; Ly, K; Asselin, MC; Day, R; Duclos, FJ; Witmer, M; Parker, R; Prat, A; Seidah, NG,期刊:Journal of Biological Chemistry, 页码:28856-28864 , 文章类型: Article,,卷期:2009年284-42]
- Elevated levels of plasma low density lipoprotein (LDL)-cholesterol, leading to familial hypercholesterolemia, are enhanced by mutations in at least three major genes, the LDL receptor (LDLR), its ligand apolipoprotein B...
- Electrochemical Measurement of Electron Transfer Kinetics by Shewanella oneidensis MR-1
[作者:Baron, D; LaBelle, E; Coursolle, D; Gralnick, JA; Bond, DR,期刊:Journal of Biological Chemistry, 页码:28865-28873 , 文章类型: Article,,卷期:2009年284-42]
- Shewanella oneidensis strain MR-1 can respire using carbon electrodes and metal oxyhydroxides as electron acceptors, requiring mechanisms for transferring electrons from the cell interior to surfaces located beyond the c...
- A Quantification of Pathway Components Supports a Novel Model of Hedgehog Signal Transduction
[作者:Farzan, SF; Stegman, MA; Ogden, SK; Ascano, M; Black, KE; Tacchelly, O; Robbins, DJ,期刊:Journal of Biological Chemistry, 页码:28874-28884 , 文章类型: Article,,卷期:2009年284-42]
- The secreted protein Hedgehog (Hh) plays a critical instructional role during metazoan development. In Drosophila, Hh signaling is interpreted by a set of conserved, downstream effectors that differentially localize and ...
- Hepatocyte Nuclear Factor 1 alpha Plays a Critical Role in PCSK9 Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine
[作者:Li, H; Dong, B; Park, SW; Lee, HS; Chen, W; Liu, JW,期刊:Journal of Biological Chemistry, 页码:28885-28895 , 文章类型: Article,,卷期:2009年284-42]
- PCSK9 is a natural inhibitor of LDL receptor (LDLR) that binds the extracellular domain of LDLR and triggers its intracellular degradation. PCSK9 and LDLR are coordinately regulated at the transcriptional level by sterol...
- Role of a Cytoplasmic Dual-function Glycosyltransferase in O-2 Regulation of Development in Dictyostelium
[作者:Wang, ZA; van der Wel, H; Vohra, Y; Buskas, T; Boons, GJ; West, CM,期刊:Journal of Biological Chemistry, 页码:28896-28904 , 文章类型: Article,,卷期:2009年284-42]
- In the social amoeba Dictyostelium, a terminal step in development is regulated by environmental O-2. Prolyl 4-hydroxylase- 1 (P4H1) was previously implicated in mediating the O-2 signal, and P4H1-null cells require elev...
- Inhibition of Cyclooxygenase-2 Down-regulates Aromatase Activity and Decreases Proliferation of Leydig Tumor Cells
[作者:Sirianni, R; Chimento, A; De Luca, A; Zolea, F; Carpino, A; Rago, V; Maggiolini, M; Ando, S; Pezzi, V,期刊:Journal of Biological Chemistry, 页码:28905-28916 , 文章类型: Article,,卷期:2009年284-42]
- Our recent studies have revealed that estrogens stimulate an autocrine mechanism determining Leydig tumor cell proliferation. Estrogen overproduction is due to an elevated steroidogenic factor-1 (SF-1) expression and cAM...
- Calcineurin Inhibitor Protein (CAIN) Attenuates Group I Metabotropic Glutamate Receptor Endocytosis and Signaling
[作者:Ferreira, LT; Dale, LB; Ribeiro, FM; Babwah, AV; Pampillo, M; Ferguson, SSG,期刊:Journal of Biological Chemistry, 页码:28986-28994 , 文章类型: Article,,卷期:2009年284-42]
- Group I metabotropic glutamate receptors (mGluRs) are coupled via phospholipase C beta to the hydrolysis of phosphoinositides and function to modulate neuronal excitability and synaptic transmission at glutamatergic syna...
- A Novel Signaling Pathway FIBROBLAST NICOTINIC RECEPTOR alpha 1 BINDS UROKINASE AND PROMOTES RENAL FIBROSIS
[作者:Zhang, GQ; Kernan, KA; Thomas, A; Collins, S; Song, YM; Li, L; Zhu, WZ; LeBoeuf, RC; Eddy, AA,期刊:Journal of Biological Chemistry, 页码:29050-29064 , 文章类型: Article,,卷期:2009年284-42]
- The nicotinic acetylcholine receptor alpha 1 (nAChR alpha 1) was investigated as a potential fibrogenic molecule in the kidney, given reports that it may be an alternative urokinase (urokinase plasminogen activator; uPA)...
- Inhibition of Prolyl Hydroxylase Protects against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity MODEL FOR THE POTENTIAL INVOLVEMENT OF THE HYPOXIA-INDUCIBLE FACTOR PATHWAY IN PARKINSON DISEASE
[作者:Lee, DW; Rajagopalan, S; Siddiq, A; Gwiazda, R; Yang, LC; Beal, MF; Ratan, RR; Andersen, JK,期刊:Journal of Biological Chemistry, 页码:29065-29076 , 文章类型: Article,,卷期:2009年284-42]
- Hypoxia-inducible factor (HIF) plays an important role in cell survival by regulating iron, antioxidant defense, and mitochondrial function. Pharmacological inhibitors of the iron-dependent enzyme class prolyl hydroxylas...
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