- Crystal Structure and Function of a DARPin Neutralizing Inhibitor of Lactococcal Phage TP901-1 COMPARISON OF DARPin AND CAMELID VHH BINDING MODE
[作者:Veesler, D; Dreier, B; Blangy, S; Lichiere, J; Tremblay, D; Moineau, S; Spinelli, S; Tegoni, M; Pluckthun, A; Campanacci, V; Cambillau, C,期刊:Journal of Biological Chemistry, 页码:30718-30726 , 文章类型: Article,,卷期:2009年284-44]
- Combinatorial libraries of designed ankyrin repeat proteins (DARPins) have been proven to be a valuable source of specific binding proteins, as they can be expressed at very high levels and are very stable. We report her...
- Sequence-specific Recognition of DNA by the C-terminal Domain of Nucleoid-associated Protein H-NS
[作者:Sette, M; Spurio, R; Trotta, E; Brandizi, C; Brandi, A; Pon, CL; Barbato, G; Boelens, R; Gualerzi, CO,期刊:Journal of Biological Chemistry, 页码:30453-30462 , 文章类型: Article,,卷期:2009年284-44]
- The molecular determinants necessary and sufficient for recognition of its specific DNA target are contained in the C-terminal domain (H-NSctd) of nucleoid-associated protein H-NS. H-NSctd protects from DNaseI cleavage a...
- Structural Mapping of Post-translational Modifications in Human Interleukin-24 ROLE OF N-LINKED GLYCOSYLATION AND DISULFIDE BONDS IN SECRETION AND ACTIVITY
[作者:Fuson, KL; Zheng, MZ; Craxton, M; Pataer, A; Ramesh, R; Chada, S; Sutton, RB,期刊:Journal of Biological Chemistry, 页码:30526-30533 , 文章类型: Article,,卷期:2009年284-44]
- Human interleukin-24 (IL-24) is unique among the IL-10 superfamily as there is considerable evidence that it possesses multiple anti-cancer properties, including direct tumor cell cytotoxicity, helper T cell (TH1) immune...
- Zebrafish and Mouse alpha 2,3-Sialyltransferases Responsible for Synthesizing GM4 Ganglioside
[作者:Chisada, S; Yoshimura, Y; Sakaguchi, K; Uemura, S; Go, S; Ikeda, K; Uchima, H; Matsunaga, N; Ogura, K; Tai, T; Okino, N; Taguchi, R; Inokuchi, J; Ito, M,期刊:Journal of Biological Chemistry, 页码:30534-30546 , 文章类型: Article,,卷期:2009年284-44]
- We have previously reported that fish pathogens causing vibriosis specifically adhere to GM4 on the epithelial cells of fish intestinal tracts (Chisada, S., Horibata, Y., Hama, Y., Inagaki, M., Furuya, N., Okino, N., and...
- Dual Activities of Odorants on Olfactory and Nuclear Hormone Receptors
[作者:Pick, H; Etter, S; Baud, O; Schmauder, R; Bordoli, L; Schwede, T; Vogel, H,期刊:Journal of Biological Chemistry, 页码:30547-30555 , 文章类型: Article,,卷期:2009年284-44]
- We have screened an odorant compound library and discovered molecules acting as chemical signals that specifically activate both G-protein-coupled olfactory receptors (ORs) on the cell surface of olfactory sensory neuron...
- Inflammatory Proprotein Convertase-Matrix Metalloproteinase Proteolytic Pathway in Antigen-presenting Cells as a Step to Autoimmune Multiple Sclerosis
[作者:Shiryaev, SA; Remacle, AG; Savinov, AY; Chernov, AV; Cieplak, P; Radichev, IA; Williams, R; Shiryaeva, TN; Gawlik, K; Postnova, TI; Ratnikov, BI; Eroshkin, AM; Motamedchaboki, K; Smith, JW; Strongin, AY,期刊:Journal of Biological Chemistry, 页码:30615-30626 , 文章类型: Article,,卷期:2009年284-44]
- Multiple sclerosis ( MS) is a disease of the central nervous system with autoimmune etiology. Susceptibility to MS is linked to viral and bacterial infections. Matrix metalloproteinases ( MMPs) play a significant role in...
- Toward Effective HIV Vaccination INDUCTION OF BINARY EPITOPE REACTIVE ANTIBODIES WITH BROAD HIV NEUTRALIZING ACTIVITY
[作者:Nishiyama, Y; Planque, S; Mitsuda, Y; Nitti, G; Taguchi, H; Jin, L; Symersky, J; Boivin, S; Sienczyk, M; Salas, M; Hanson, CV; Paul, S,期刊:Journal of Biological Chemistry, 页码:30627-30642 , 文章类型: Article,,卷期:2009年284-44]
- We describe murine monoclonal antibodies (mAbs) raised by immunization with an electrophilic gp120 analog (E-gp120) expressing the rare ability to neutralize genetically heterologous human immunodeficiency virus (HIV) st...
- Identification of Amino Acids in the N-terminal Domain of Atypical Methanogenic-type Seryl-tRNA Synthetase Critical for tRNA Recognition
[作者:Jaric, J; Bilokapic, S; Lesjak, S; Crnkovic, A; Ban, N; Weygand-Durasevic, I,期刊:Journal of Biological Chemistry, 页码:30643-30651 , 文章类型: Article,,卷期:2009年284-44]
- Seryl-tRNA synthetase (SerRS) from methanogenic archaeon Methanosarcina barkeri, contains an idiosyncratic N-terminal domain, composed of an antiparallel beta-sheet capped by a helical bundle, connected to the catalytic ...
- Coordination of Polymerization, Chain Termination, and Export in Assembly of the Escherichia coli Lipopolysaccharide O9a Antigen in an ATP-binding Cassette Transporter-dependent Pathway
[作者:Clarke, BR; Greenfield, LK; Bouwman, C; Whitfield, C,期刊:Journal of Biological Chemistry, 页码:30662-30672 , 文章类型: Article,,卷期:2009年284-44]
- The Escherichia coli O9a O-polysaccharide (O-PS) is a prototype for O-PS synthesis and export by the ATP-binding cassette transporter-dependent pathway. Comparable systems are widespread in Gram-negative bacteria. The po...
- Modulation of Hyaluronan Synthase Activity in Cellular Membrane Fractions
[作者:Vigetti, D; Genasetti, A; Karousou, E; Viola, M; Clerici, M; Bartolini, B; Moretto, P; De Luca, G; Hascall, VC; Passi, A,期刊:Journal of Biological Chemistry, 页码:30684-30694 , 文章类型: Article,,卷期:2009年284-44]
- Hyaluronan ( HA), the only non-sulfated glycosaminoglycan, is involved in morphogenesis, wound healing, inflammation, angiogenesis, and cancer. In mammals, HA is synthesized by three homologous HA synthases, HAS1, HAS2, ...
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