- Binding and Cleavage Specificities of Human Argonaute2
[作者:Lima, WF; Wu, HJ; Nichols, JG; Sun, H; Murray, HM; Crooke, ST,期刊:Journal of Biological Chemistry, 页码:26017-26028 , 文章类型: Article,,卷期:2009年284-38]
- The endonuclease Argonaute2 (Ago2) mediates the degradation of the target mRNA within the RNA-induced silencing complex. We determined the binding and cleavage properties of recombinant human Ago2. Human Ago2 was unable ...
- Protein Kinase C-delta Transactivates Platelet-derived Growth Factor Receptor-alpha in Mechanical Strain-induced Collagenase 3 (Matrix Metalloproteinase-13) Expression by Osteoblast-like Cells
[作者:Yang, CM; Hsieh, HL; Yao, CC; Hsiao, LD; Tseng, CP; Wu, CB,期刊:Journal of Biological Chemistry, 页码:26040-26050 , 文章类型: Article,,卷期:2009年284-38]
- Matrix metalloproteinase-13 (MMP-13, or collagenase 3) has been shown to degrade intact collagen and to participate in situations where rapid and effective remodeling of collagenous ECM is required. Mechanical strain ind...
- Evidence for the Direct Interaction of Spermine with the Inwardly Rectifying Potassium Channel
[作者:Osawa, M; Yokogawa, M; Muramatsu, T; Kimura, T; Mase, Y; Shimada, I,期刊:Journal of Biological Chemistry, 页码:26117-26126 , 文章类型: Article,,卷期:2009年284-38]
- The inwardly rectifying potassium channel (Kir) regulates resting membrane potential, K+ homeostasis, heart rate, and hormone secretion. The outward current is blocked in a voltage-dependent manner, upon the binding of i...
- Pro-interleukin (IL)-1 beta Shares a Core Region of Stability as Compared with Mature IL-1 beta While Maintaining a Distinctly Different Configurational Landscape A COMPARATIVE HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY STUDY
[作者:Hailey, KL; Li, S; Andersen, MD; Roy, M; Woods, VL; Jennings, PA,期刊:Journal of Biological Chemistry, 页码:26137-26148 , 文章类型: Article,,卷期:2009年284-38]
- Interleukin-1 beta (IL-1 beta) is a master cytokine involved in initiating the innate immune response in vertebrates (Dinarello, C. A. (1994) FASEB J. 8, 1314-1325). It is first synthesized as an inactive 269-residue pre...
- Fragile X Mental Retardation Protein Regulates the Levels of Scaffold Proteins and Glutamate Receptors in Postsynaptic Densities
[作者:Schutt, J; Falley, K; Richter, D; Kreienkamp, HJ; Kindler, S,期刊:Journal of Biological Chemistry, 页码:25479-25487 , 文章类型: Article,,卷期:2009年284-38]
- Functional absence of fragile X mental retardation protein (FMRP) causes the fragile X syndrome, a hereditary form of mental retardation characterized by a change in dendritic spine morphology. The RNA-binding protein FM...
- Transcriptional Activation of the Interleukin-21 Gene and Its Receptor Gene by Human T-cell Leukemia Virus Type 1 Tax in Human T-cells
[作者:Mizuguchi, M; Asao, H; Hara, T; Higuchi, M; Fujii, M; Nakamura, M,期刊:Journal of Biological Chemistry, 页码:25501-25511 , 文章类型: Article,,卷期:2009年284-38]
- At the incipient stages of the development of adult T-cell leukemia, T-cells infected with human T-cell leukemia virus type 1 (HTLV-1) suffer disregulation in cell growth caused by aberrant expression of host genes by th...
- Intrinsic Voltage Dependence of the Epithelial Na+ Channel Is Masked by a Conserved Transmembrane Domain Tryptophan
[作者:Pochynyuk, O; Kucher, V; Boiko, N; Mironova, E; Staruschenko, A; Karpushev, AV; Tong, QS; Hendron, E; Stockand, J,期刊:Journal of Biological Chemistry, 页码:25512-25521 , 文章类型: Article,,卷期:2009年284-38]
- Tryptophan residues critical to function are frequently located at the lipid-water interface of transmembrane domains. All members of the epithelial Na+ channel (ENaC)/Degenerin (Deg) channel superfamily contain an absol...
- Toll-like Receptor 2 and DC-SIGNR1 Differentially Regulate Suppressors of Cytokine Signaling 1 in Dendritic Cells during Mycobacterium tuberculosis Infection
[作者:Srivastava, V; Manchanda, M; Gupta, S; Singla, R; Behera, D; Das, G; Natarajan, K,期刊:Journal of Biological Chemistry, 页码:25532-25541 , 文章类型: Article,,卷期:2009年284-38]
- A hallmark of protective immunity during Mycobacterium tuberculosis (M. tb) infection is the regulated secretion of pro-inflammatory and regulatory cytokines. Suppressors of Cytokine Signaling (SOCS) are key regulators o...
- Translesional DNA Synthesis through a C8-Guanyl Adduct of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro REV1 INSERTS dC OPPOSITE THE LESION, AND DNA POLYMERASE kappa POTENTIALLY CATALYZES EXTENSION REACTION FROM THE 3 '-dC TERMINUS
[作者:Fukuda, H; Takamura-Enya, T; Masuda, Y; Nohmi, T; Seki, C; Kamiya, K; Sugimura, T; Masutani, C; Hanaoka, F; Nakagama, H,期刊:Journal of Biological Chemistry, 页码:25585-25592 , 文章类型: Article,,卷期:2009年284-38]
- 2-Amino-1-methyl-6-phenylimidazo[4,5-b] pyridine ( PhIP) is the most abundant heterocyclic amine in cooked foods, and is both mutagenic and carcinogenic. It has been suspected that the carcinogenicity of PhIP is derived ...
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