- The Developmentally Regulated Osteoblast Phosphodiesterase GDE3 Is Glycerophosphoinositol-specific and Modulates Cell Growth
[作者:Corda, D; Kudo, T; Zizza, P; Iurisci, C; Kawai, E; Kato, N; Yanaka, N; Mariggio, S,期刊:Journal of Biological Chemistry, 页码:24848-24856 , 文章类型: Article,,卷期:2009年284-37]
- The glycerophosphodiester phosphodiesterase enzyme family involved in the hydrolysis of glycerophosphodiesters has been characterized in bacteria and recently identified in mammals. Here, we have characterized the activi...
- Cell Polarity Factor Par3 Binds SPTLC1 and Modulates Monocyte Serine Palmitoyltransferase Activity and Chemotaxis
[作者:Tamehiro, N; Mujawar, Z; Zhou, SP; Zhuang, DZ; Hornemann, T; von Eckardstein, A; Fitzgerald, ML,期刊:Journal of Biological Chemistry, 页码:24881-24890 , 文章类型: Article,,卷期:2009年284-37]
- Elevated sphingolipids have been associated with increased cardiovascular disease. Conversely, atherosclerosis is reduced in mice by blocking de novo synthesis of sphingolipids catalyzed by serine palmitoyltransferase (S...
- Subcomplexes of PA700, the 19 S Regulator of the 26 S Proteasome, Reveal Relative Roles of AAA Subunits in 26 S Proteasome Assembly and Activation and ATPase Activity
[作者:Thompson, D; Hakala, K; DeMartino, GN,期刊:Journal of Biological Chemistry, 页码:24891-24903 , 文章类型: Article,,卷期:2009年284-37]
- We have identified, purified, and characterized three subcomplexes of PA700, the 19 S regulatory complex of the 26 S proteasome. These subcomplexes (denoted PS-1, PS-2, and PS-3) collectively account for all subunits pre...
- Kruppel-like Factor KLF10 Targets Transforming Growth Factor-beta 1 to Regulate CD4(+)CD25(-) T Cells and T Regulatory Cells
[作者:Cao, ZX; Wara, AK; Icli, B; Sun, XH; Packard, RRS; Esen, F; Stapleton, CJ; Subramaniam, M; Kretschmer, K; Apostolou, I; von Boehmer, H; Hansson, GK; Spelsberg, TC; Libby, P; Feinberg, MW,期刊:Journal of Biological Chemistry, 页码:24914-24924 , 文章类型: Article,,卷期:2009年284-37]
- CD4(+)CD25(+) regulatory T cells (T regs) play a major role in the maintenance of self-tolerance and immune suppression, although the mechanisms controlling T reg development and suppressor function remain incompletely u...
- A Ca2+ Release-activated Ca2+ (CRAC) Modulatory Domain (CMD) within STIM1 Mediates Fast Ca2+-dependent Inactivation of ORAI1 Channels
[作者:Derler, I; Fahrner, M; Muik, M; Lackner, B; Schindl, R; Groschner, K; Romanin, C,期刊:Journal of Biological Chemistry, 页码:24933-24938 , 文章类型: Article,,卷期:2009年284-37]
- STIM1 and ORAI1, the two limiting components in the Ca2+ release-activated Ca2+ (CRAC) signaling cascade, have been reported to interact upon store depletion, culminating in CRAC current activation. We have recently iden...
- Mitochondrial Glutamate Carrier GC1 as a Newly Identified Player in the Control of Glucose-stimulated Insulin Secretion
[作者:Casimir, M; Lasorsa, FM; Rubi, B; Caille, D; Palmieri, F; Meda, P; Maechler, P,期刊:Journal of Biological Chemistry, 页码:25004-25014 , 文章类型: Article,,卷期:2009年284-37]
- The SLC25 carrier family mediates solute transport across the inner mitochondrial membrane, a process that is still poorly characterized regarding both the mechanisms and proteins implicated. This study investigated mito...
- A beta-L-Arabinopyranosidase from Streptomyces avermitilis Is a Novel Member of Glycoside Hydrolase Family 27
[作者:Ichinose, H; Fujimoto, Z; Honda, M; Harazono, K; Nishimoto, Y; Uzura, A; Kaneko, S,期刊:Journal of Biological Chemistry, 页码:25097-25106 , 文章类型: Article,,卷期:2009年284-37]
- Arabinogalactan proteins (AGPs) are a family of plant cell surface proteoglycans and are considered to be involved in plant growth and development. Because AGPs are very complex molecules, glycoside hydrolases capable of...
- Preferential Inhibition of BMAL2-CLOCK Activity by PER2 Reemphasizes Its Negative Role and a Positive Role of BMAL2 in the Circadian Transcription
[作者:Sasaki, M; Yoshitane, H; Du, NH; Okano, T; Fukada, Y,期刊:Journal of Biological Chemistry, 页码:25149-25159 , 文章类型: Article,,卷期:2009年284-37]
- In the molecular oscillatory mechanism governing circadian rhythms, positive regulators, including CLOCK and BMAL1, transactivate Per and Cry genes through E-box elements, and translated PER and CRY proteins negatively r...
- Molecular Regulation of Matrix Extracellular Phosphoglycoprotein Expression by Bone Morphogenetic Protein-2
[作者:Cho, YD; Yoon, WJ; Woo, KM; Baek, JH; Lee, G; Cho, JY; Ryoo, HM,期刊:Journal of Biological Chemistry, 页码:25230-25240 , 文章类型: Article,,卷期:2009年284-37]
- Matrix extracellular phosphoglycoprotein (MEPE) is mainly expressed in mineralizing tissues, and its C-terminal proteolytic cleavage product is an acidic-serine-asparate-rich-MEPE-associated motif (ASARM) that is a stron...
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