- Goodpasture Antigen-binding Protein Is a Soluble Exportable Protein That Interacts with Type IV Collagen IDENTIFICATION OF NOVEL MEMBRANE-BOUND ISOFORMS
[作者:Revert, F; Ventura, I; Martinez-Martinez, P; Granero-Molto, F; Revert-Ros, F; Macias, J; Saus, J,期刊:Journal of Biological Chemistry, 页码:30246-30255 , 文章类型: Article,,卷期:2008年283-44]
- Goodpasture-antigen binding protein (GPBP) is a nonconventional Ser/Thr kinase for basement membrane type IV collagen. Various studies have questioned these findings and proposed that GPBP serves as transporter of cerami...
- The Interaction between an Acidic Transcriptional Activator and Its Inhibitor THE MOLECULAR BASIS OF Gal4p RECOGNITION BY Gal80p
[作者:Thoden, JB; Ryan, LA; Reece, RJ; Holden, HM,期刊:Journal of Biological Chemistry, 页码:30266-30272 , 文章类型: Article,,卷期:2008年283-44]
- The GAL genes, which encode the enzymes required for normal galactose metabolism in yeast, are transcriptionally regulated by three proteins: Gal4p, an activator; Gal80p, an inhibitor; and Gal3p, a galactose sensor. Thes...
- 15-Deoxy-Delta(12,14)-prostaglandin J(2) Induces Vascular Endothelial Cell Apoptosis through the Sequential Activation of MAPKS and p53
[作者:Ho, TC; Chen, SL; Yang, YC; Chen, CY; Feng, FP; Hsieh, JW; Cheng, HC; Tsao, YP,期刊:Journal of Biological Chemistry, 页码:30273-30288 , 文章类型: Article,,卷期:2008年283-44]
- 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a potent anti-angiogenic factor and induces endothelial cell apoptosis, although the mechanism remains unclear. In this study, 15d-PGJ(2) was found to increase p53...
- Three-dimensional Reconstruction of Human Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Revealed an Ellipsoidal Structure with Orifices beneath the Putative Transmembrane Domain
[作者:Mio, K; Ogura, T; Mio, M; Shimizu, H; Hwang, TC; Sato, C; Sohma, Y,期刊:Journal of Biological Chemistry, 页码:30300-30310 , 文章类型: Article,,卷期:2008年283-44]
- The cystic fibrosis transmembrane conductance regulator ( CFTR) chloride channel is a membrane-integral protein that belongs to an ATP-binding cassette superfamily. Mutations in the CFTR gene cause cystic fibrosis in whi...
- Structural, Functional, and Mutational Analysis of the NblA Protein Provides Insight into Possible Modes of Interaction with the Phycobilisome
[作者:Dines, M; Sendersky, E; David, L; Schwarz, R; Adir, N,期刊:Journal of Biological Chemistry, 页码:30330-30340 , 文章类型: Article,,卷期:2008年283-44]
- The enormous macromolecular phycobilisome antenna complex (>4 MDa) in cyanobacteria and red algae undergoes controlled degradation during certain forms of nutrient starvation. The NblA protein (similar to 6 kDa) has been...
- Benzyl Isothiocyanate Targets Mitochondrial Respiratory Chain to Trigger Reactive Oxygen Species-dependent Apoptosis in Human Breast Cancer Cells
[作者:Xiao, D; Powolny, AA; Singh, SV,期刊:Journal of Biological Chemistry, 页码:30151-30163 , 文章类型: Article,,卷期:2008年283-44]
- Benzyl isothiocyanate (BITC), a dietary cancer chemopreventive agent, causes apoptosis in MDA-MB-231 and MCF-7 human breast cancer cells, but the mechanism of cell death is not fully understood. We now demonstrate that t...
- The Role of Amyloid Precursor Protein Processing by BACE1, the beta-Secretase, in Alzheimer Disease Pathophysiology
[作者:Cole, SL; Vassar, R,期刊:Journal of Biological Chemistry, 页码:29621-29625 , 文章类型: Review,,卷期:2008年283-44]
- Amyloid plaques, composed of the amyloid beta-protein (A beta), are hallmark neuropathological lesions in Alzheimer disease (AD) brain. A beta fulfills a central role in AD pathogenesis, and reduction of A beta levels sh...
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