- Engagement of beta-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation
[作者:Oligny-Longpre, G; Corbani, M; Zhou, J; Hogue, M; Guillon, G; Bouvier, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1028-E1037 , 文章类型: Article,,卷期:2012年109-17]
- G protein-coupled receptors (GPCRs) have been shown to activate the mitogen-activated protein kinases, ERK1/2, through both G protein-dependent and -independent mechanisms. Here, we describe a G protein-independent mecha...
- Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III
[作者:Bezerra, GA; Dobrovetsky, E; Viertlmayr, R; Dong, A; Binter, A; Abramic, M; Macheroux, P; Dhe-Paganon, S; Gruber, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6525-6530 , 文章类型: Article,,卷期:2012年109-17]
- Opioid peptides are involved in various essential physiological processes, most notably nociception. Dipeptidyl peptidase III (DPP III) is one of the most important enkephalin-degrading enzymes associated with the mammal...
- ErbB receptor tyrosine kinase/NF-kappa B signaling controls mammosphere formation in human breast cancer
[作者:Hinohara, K; Kobayashi, S; Kanauchi, H; Shimizu, S; Nishioka, K; Tsuji, E; Tada, K; Umezawa, K; Mori, M; Ogawa, T; Inoue, J; Tojo, A; Gotoh, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6584-6589 , 文章类型: Article,,卷期:2012年109-17]
- Breast cancer is one of the most common cancers in humans. However, our understanding of the cellular and molecular mechanisms underlying tumorigenesis in breast tissues is limited. Here, we identified a molecular mechan...
- ESR spectroscopy identifies inhibitory Cu2+ sites in a DNA-modifying enzyme to reveal determinants of catalytic specificity
[作者:Yang, ZY; Kurpiewski, MR; Ji, M; Townsend, JE; Mehta, P; Jen-Jacobson, L; Saxena, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E993-E1000 , 文章类型: Article,,卷期:2012年109-17]
- The relationship between DNA sequence recognition and catalytic specificity in a DNA-modifying enzyme was explored using paramagnetic Cu2+ ions as probes for ESR spectroscopic and biochemical studies. Electron spin echo ...
- Structure of the Plasmodium 6-cysteine s48/45 domain
[作者:Arredondo, SA; Cai, ML; Takayama, Y; MacDonald, NJ; Anderson, DE; Aravind, L; Clore, GM; Miller, LH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6692-6697 , 文章类型: Article,,卷期:2012年109-17]
- The s48/45 domain was first noted in Plasmodium proteins more than 15 y ago. Previously believed to be unique to Plasmodium, the s48/45 domain is present in other aconoidasidans. In Plasmodium, members of the s48/45 fami...
- Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates
[作者:Senejani, AG; Dalal, S; Liu, YF; Nottoli, TP; McGrath, JM; Clairmont, CS; Sweasy, JB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6632-6637 , 文章类型: Article,,卷期:2012年109-17]
- DNA is susceptible to damage by a wide variety of chemical agents that are generated either as byproducts of cellular metabolism or exposure to man-made and harmful environments. Therefore, to maintain genomic integrity,...
- Neural basis of egalitarian behavior
[作者:Dawes, CT; Loewen, PJ; Schreiber, D; Simmons, AN; Flagan, T; McElreath, R; Bokemper, SE; Fowler, JH; Paulus, MP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6479-6483 , 文章类型: Article,,卷期:2012年109-17]
- Individuals are willing to sacrifice their own resources to promote equality in groups. These costly choices promote equality and are associated with behavior that supports cooperation in humans, but little is known abou...
- Interfacial electronic effects in functional biolayers integrated into organic field-effect transistors
[作者:Angione, MD; Cotrone, S; Magliulo, M; Mallardi, A; Altamura, D; Giannini, C; Cioffi, N; Sabbatini, L; Fratini, E; Baglioni, P; Scamarcio, G; Palazzo, G; Torsi, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6429-6434 , 文章类型: Article,,卷期:2012年109-17]
- Biosystems integration into an organic field-effect transistor (OFET) structure is achieved by spin coating phospholipid or protein layers between the gate dielectric and the organic semiconductor. An architecture direct...
- Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death
[作者:Gammoh, N; Lam, D; Puente, C; Ganley, I; Marks, PA; Jiang, XJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6561-6565 , 文章类型: Article,,卷期:2012年109-17]
- Autophagy is a cellular catabolic pathway by which long-lived proteins and damaged organelles are targeted for degradation. Activation of autophagy enhances cellular tolerance to various stresses. Recent studies indicate...
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