- Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
[作者:Bilican, B; Serio, A; Barmada, SJ; Nishimura, AL; Sullivan, GJ; Carrasco, M; Phatnani, HP; Puddifoot, CA; Story, D; Fletcher, J; Park, IH; Friedman, BA; Daley, GQ; Wyllie, DJA; Hardingham, GE; Wilmut, I; Finkbeiner, S; Maniatis, T; Shaw, CE; Chandran, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5803-5808 , 文章类型: Article,,卷期:2012年109-15]
- Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in amyotrophic lateral sclerosis (ALS) and a subgroup of frontotemporal lobar degeneration (FTLD-TDP). Identification of mutations in the ...
- Resolving the complex role of enzyme conformational dynamics in catalytic function
[作者:Doshi, U; McGowan, LC; Ladani, ST; Hamelberg, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5699-5704 , 文章类型: Article,,卷期:2012年109-15]
- Despite growing evidence suggesting the importance of enzyme conformational dynamics (ECD) in catalysis, a consensus on how precisely ECD influences the chemical step and reaction rates is yet to be reached. Here, we cha...
- Action potential propagation in transverse-axial tubular system is impaired in heart failure
[作者:Sacconi, L; Ferrantini, C; Lotti, J; Coppini, R; Yan, P; Loew, LM; Tesi, C; Cerbai, E; Poggesi, C; Pavone, FS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5815-5819 , 文章类型: Article,,卷期:2012年109-15]
- The plasma membrane of cardiac myocytes presents complex invaginations known as the transverse-axial tubular system (TATS). Despite TATS's crucial role in excitation-contraction coupling and morphological alterations fou...
- Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP
[作者:Beilharz, K; Novakova, L; Fadda, D; Branny, P; Massidda, O; Veening, JW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E905-E913 , 文章类型: Article,,卷期:2012年109-15]
- How the human pathogen Streptococcus pneumoniae coordinates cell-wall synthesis during growth and division to achieve its characteristic oval shape is poorly understood. The conserved eukaryotic-type Ser/Thr kinase of S....
- Evidence for a Peierls phase-transition in a three-dimensional multiple charge-density waves solid
[作者:Mansart, B; Cottet, MJG; Penfold, TJ; Dugdale, SB; Tediosi, R; Chergui, M; Carbone, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5603-5608 , 文章类型: Article,,卷期:2012年109-15]
- The effect of dimensionality on materials properties has become strikingly evident with the recent discovery of graphene. Charge ordering phenomena can be induced in one dimension by periodic distortions of a material's ...
- RNA binding and RNA remodeling activities of the half-a-tetratricopeptide (HAT) protein HCF107 underlie its effects on gene expression
[作者:Hammani, K; Cook, WB; Barkan, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5651-5656 , 文章类型: Article,,卷期:2012年109-15]
- The half-a-tetratricopeptide repeat (HAT) motif is a helical repeat motif found in proteins that influence various aspects of RNA metabolism, including rRNA biogenesis, RNA splicing, and polyadenylation. This functional ...
- Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation
[作者:Chang, YF; Lee-Chang, JS; Imam, JS; Buddavarapu, KC; Subaran, SS; Sinha-Hikim, AP; Gorospe, M; Rao, MK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5750-5755 , 文章类型: Article,,卷期:2012年109-15]
- Decoupling of transcription and translation during postmeiotic germ cell differentiation is critical for successful spermatogenesis. Here we establish that the interaction between microRNAs and actin-associated protein A...
- Ni(II) coordination to mixed sites modulates DNA binding of HpNikR via a long- range effect
[作者:West, AL; Evans, SE; Gonzalez, JM; Carter, LG; Tsuruta, H; Pozharski, E; Michel, SLJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5633-5638 , 文章类型: Article,,卷期:2012年109-15]
- Helicobacter pylori NikR (HpNikR) is a nickel-dependent transcription factor that regulates multiple genes in the H. pylori pathogen. There are conflicting data regarding the locations of the Ni(II) sites and the role of...
- Nonprocessive [2+2]e(-) off-loading reductase domains from mycobacterial nonribosomal peptide synthetases
[作者:Chhabra, A; Haque, AS; Pal, RK; Goyal, A; Rai, R; Joshi, S; Panjikar, S; Pasha, S; Sankaranarayanan, R; Gokhale, RS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5681-5686 , 文章类型: Article,,卷期:2012年109-15]
- In mycobacteria, polyketide synthases and nonribosomal peptide synthetases (NRPSs) produce complex lipidic metabolites by using a thio-template mechanism of catalysis. In this study, we demonstrate that off-loading reduc...
- Co-transplantation of pure blood stem cells with antigen-specific but not bulk T cells augments functional immunity
[作者:Muller, AMS; Shashidhar, S; Kupper, NJ; Kohrt, HEK; Florek, M; Negrin, RS; Brown, JM; Shizuru, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5820-5825 , 文章类型: Article,,卷期:2012年109-15]
- Impaired immunity is a fundamental obstacle to successful allogeneic hematopoietic cell transplantation. Mature graft T cells are thought to provide protection from infections early after transplantation, but can cause l...
- Interaction with plant transcription factors can mediate nuclear import of phytochrome B
[作者:Pfeiffer, A; Nagel, MK; Popp, C; Wust, F; Bindics, J; Viczian, A; Hiltbrunner, A; Nagy, F; Kunkel, T; Schafer, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5892-5897 , 文章类型: Article,,卷期:2012年109-15]
- Phytochromes (phy) are red/far-red-absorbing photoreceptors that regulate the adaption of plant growth and development to changes in ambient light conditions. The nuclear transport of the phytochromes upon light activati...
- On the Waring problem for polynomial rings
[作者:Froberg, R; Ottaviani, G; Shapiro, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5600-5602 , 文章类型: Article,,卷期:2012年109-15]
- In this note we discuss an analog of the classical Waring problem for C[x(0),x(1),..., x(n)]- Namely, we show that a general homogeneous polynomial p is an element of C[x(0),x(1),..,x(n)] of degree divisible by k >= 2 ca...
- Cyanobacteria produce a high variety of hepatotoxic peptides in lichen symbiosis
[作者:Kaasalainen, U; Fewer, DP; Jokela, J; Wahlsten, M; Sivonen, K; Rikkinen, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5886-5891 , 文章类型: Article,,卷期:2012年109-15]
- Lichens are symbiotic associations between fungi and photosynthetic algae or cyanobacteria. Microcystins are potent toxins that are responsible for the poisoning of both humans and animals. These toxins are mainly associ...
- Decade-long bacterial community dynamics in cystic fibrosis airways
[作者:Zhao, JC; Schloss, PD; Kalikin, LM; Carmody, LA; Foster, BK; Petrosino, JF; Cavalcoli, JD; VanDevanter, DR; Murray, S; Li, JZ; Young, VB; LiPuma, JJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5809-5814 , 文章类型: Article,,卷期:2012年109-15]
- The structure and dynamics of bacterial communities in the airways of persons with cystic fibrosis (CF) remain largely unknown. We characterized the bacterial communities in 126 sputum samples representing serial collect...
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