- DNA cleavage and opening reactions of human topoisomerase II alpha are regulated via Mg2+-mediated dynamic bending of gate-DNA
[作者:Lee, S; Jung, SR; Heo, K; Byl, JAW; Deweese, JE; Osheroff, N; Hohng, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2925-2930 , 文章类型: Article,,卷期:2012年109-8]
- Topoisomerase II resolves intrinsic topological problems of double-stranded DNA. As part of its essential cellular functions, the enzyme generates DNA breaks, but the regulation of this potentially dangerous process is n...
- Skeletal muscle transcriptional coactivator PGC-1 alpha mediates mitochondrial, but not metabolic, changes during calorie restriction
[作者:Finley, LWS; Lee, J; Souza, A; Desquiret-Dumas, V; Bullock, K; Rowe, GC; Procaccio, V; Clish, CB; Arany, Z; Haigis, MC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2931-2936 , 文章类型: Article,,卷期:2012年109-8]
- Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation, and reactive oxygen species (ROS) scavenging...
- Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity
[作者:Tsutsumi, S; Mollapour, M; Prodromou, C; Lee, CT; Panaretou, B; Yoshida, S; Mayer, MP; Neckers, LM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2937-2942 , 文章类型: Article,,卷期:2012年109-8]
- Hsp90 is an essential and highly conserved modular molecular chaperone whose N and middle domains are separated by a disordered region termed the charged linker. Although its importance has been previously disregarded, b...
- Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production
[作者:Fu, M; Zhang, WH; Wu, LY; Yang, GD; Li, HZ; Wang, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2943-2948 , 文章类型: Article,,卷期:2012年109-8]
- Although many types of ancient bacteria and archea rely on hydrogen sulfide (H2S) for their energy production, eukaryotes generate ATP in an oxygen-dependent fashion. We hypothesize that endogenous H2S remains a regulato...
- A Y-linked anti-Mullerian hormone duplication takes over a critical role in sex determination
[作者:Hattori, RS; Murai, Y; Oura, M; Masuda, S; Majhi, SK; Sakamoto, T; Fernandino, JI; Somoza, GM; Yokota, M; Strussmann, CA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2955-2959 , 文章类型: Article,,卷期:2012年109-8]
- Gonadal sex determination in vertebrates generally follows a sequence of genetically programmed events. In what is seemingly becoming a pattern, all confirmed or current candidate "master" sex-determining genes reported ...
- Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substrates
[作者:Huang, RQ; Hippauf, F; Rohrbeck, D; Haustein, M; Wenke, K; Feike, J; Sorrelle, N; Piechulla, B; Barkman, TJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2966-2971 , 文章类型: Article,,卷期:2012年109-8]
- In this study, we investigated the role for ancestral functional variation that may be selected upon to generate protein functional shifts using ancestral protein resurrection, statistical tests for positive selection, f...
|