- Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae
[作者:Stecher, B; Denzler, R; Maier, L; Bernet, F; Sanders, MJ; Pickard, DJ; Barthel, M; Westendorf, AM; Krogfelt, KA; Walker, AW; Ackermann, M; Dobrindt, U; Thomson, NR; Hardt, WD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1269-1274 , 文章类型: Article,,卷期:2012年109-4]
- The mammalian gut harbors a dense microbial community interacting in multiple ways, including horizontal gene transfer (HGT). Pangenome analyses established particularly high levels of genetic flux between Gram-negative ...
- An rhs gene of Pseudomonas aeruginosa encodes a virulence protein that activates the inflammasome
[作者:Kung, VL; Khare, S; Stehlik, C; Bacon, EM; Hughes, AJ; Hauser, AR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1275-1280 , 文章类型: Article,,卷期:2012年109-4]
- The rhs genes are a family of enigmatic composite genes, widespread among Gram-negative bacteria. In this study, we characterized rhsT, a Pseudomonas aeruginosa rhs gene that encodes a toxic protein. Expression of rhsT w...
- How Staphylococcus aureus biofilms develop their characteristic structure
[作者:Periasamy, S; Joo, HS; Duong, AC; Bach, THL; Tan, VY; Chatterjee, SS; Cheung, GYC; Otto, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1281-1286 , 文章类型: Article,,卷期:2012年109-4]
- Biofilms cause significant problems in the environment and during the treatment of infections. However, the molecular mechanisms underlying biofilm formation are poorly understood. There is a particular lack of knowledge...
- Unveiling the biosynthetic puzzle of destruxins in Metarhizium species
[作者:Wang, B; Kang, QJ; Lu, YZ; Bai, LQ; Wang, CS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1287-1292 , 文章类型: Article,,卷期:2012年109-4]
- Insect pathogenic fungi produce a plethora of insecticidally and pharmaceutically active compounds, including 39 cyclohexadepsi-peptide destruxins (dtxs). Even though dtxs were first discovered more than 50 y ago, the ge...
- Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway
[作者:Morikawa, T; Kajimura, M; Nakamura, T; Hishiki, T; Nakanishi, T; Yukutake, Y; Nagahata, Y; Ishikawa, M; Hattori, K; Takenouchi, T; Takahashi, T; Ishii, I; Matsubara, K; Kabe, Y; Uchiyama, S; Nagata, E; Gadalla, MM; Snyder, SH; Suematsu, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1293-1298 , 文章类型: Article,,卷期:2012年109-4]
- Enhancement of cerebral blood flow by hypoxia is critical for brain function, but signaling systems underlying its regulation have been unclear. We report a pathway mediating hypoxia-induced cerebral vasodilation in stud...
- Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination
[作者:Chong, SYC; Rosenberg, SS; Fancy, SPJ; Zhao, C; Shen, YAA; Hahn, AT; Mcgee, AW; Xu, XM; Zheng, BH; Zhang, LI; Rowitch, DH; Franklin, RJM; Lu, QR; Chan, JR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1299-1304 , 文章类型: Article,,卷期:2012年109-4]
- A requisite component of nervous system development is the achievement of cellular recognition and spatial segregation through competition-based refinement mechanisms. Competition for available axon space by myelinating ...
- BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus
[作者:Jeanneteau, FD; Lambert, WM; Ismaili, N; Bath, KG; Lee, FS; Garabedian, MJ; Chao, MV,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1305-1310 , 文章类型: Article,,卷期:2012年109-4]
- Regulation of the hypothalamic-pituitary-adrenal (HPA) axis is critical for adaptation to environmental changes. The principle regulator of the HPA axis is corticotrophin-releasing hormone (CRH), which is made in the par...
- Homeostatic plasticity mechanisms are required for juvenile, but not adult, ocular dominance plasticity
[作者:Ranson, A; Cheetham, CEJ; Fox, K; Sengpiel, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1311-1316 , 文章类型: Article,,卷期:2012年109-4]
- Ocular dominance (OD) plasticity in the visual cortex is a classic model system for understanding developmental plasticity, but the visual cortex also shows plasticity in adulthood. Whether the plasticity mechanisms are ...
- Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis
[作者:Gomez-Gaviro, MV; Scott, CE; Sesay, AK; Matheu, A; Booth, S; Galichet, C; Lovell-Badge, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1317-1322 , 文章类型: Article,,卷期:2012年109-4]
- Neural stem cells (NSCs) reside in specialized niches in the adult mammalian brain, including the subventricular zone and the dentate gyrus, which act to control NSC behavior. Among other cell types within these niches, ...
- beta 3 integrin interacts directly with GluA2 AMPA receptor subunit and regulates AMPA receptor expression in hippocampal neurons
[作者:Pozo, K; Cingolani, LA; Bassani, S; Laurent, F; Passafaro, M; Goda, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1323-1328 , 文章类型: Article,,卷期:2012年109-4]
- The integrins are transmembrane receptors for ECM proteins, and they regulate various cellular functions in the central nervous system. In hippocampal neurons, the beta 3 integrin subtype is required for homeostatic syna...
- Metabolic click-labeling with a fucose analog reveals pectin delivery, architecture, and dynamics in Arabidopsis cell walls
[作者:Anderson, CT; Wallace, IS; Somerville, CR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1329-1334 , 文章类型: Article,,卷期:2012年109-4]
- Polysaccharide-rich cell walls are a defining feature of plants that influence cell division and growth, but many details of cell-wall organization and dynamics are unknown because of a lack of suitable chemical probes. ...
- Phytochrome regulates translation of mRNA in the cytosol
[作者:Paik, I; Yang, S; Choi, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1335-1340 , 文章类型: Article,,卷期:2012年109-4]
- An array of photoreceptors including cryptochromes, phototropin, and phytochromes regulates various light responses in plants. Among these photoreceptors, phytochromes perceive red and far-red light by switching between ...
- Modulation of NF-kappa B-dependent gene transcription using programmable DNA minor groove binders
[作者:Raskatov, JA; Meier, JL; Puckett, JW; Yang, F; Ramakrishnan, P; Dervan, PB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1023-1028 , 文章类型: Article,,卷期:2012年109-4]
- Nuclear factor kappa B (NF-kappa B) is a transcription factor that regulates various aspects of immune response, cell death, and differentiation as well as cancer. In this study we introduce the Py-Im polyamide 1 that bi...
- Decoupling of deforestation and soy production in the southern Amazon during the late 2000s
[作者:Macedo, MN; DeFries, RS; Morton, DC; Stickler, CM; Galford, GL; Shimabukuro, YE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1341-1346 , 文章类型: Article,,卷期:2012年109-4]
- From 2006 to 2010, deforestation in the Amazon frontier state of Mato Grosso decreased to 30% of its historical average (1996-2005) whereas agricultural production reached an all-time high. This study combines satellite ...
- TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2
[作者:Delhase, M; Kim, SY; Lee, H; Naiki-Ito, A; Chen, Y; Ahn, ER; Murata, K; Kim, SJ; Lautsch, N; Kobayashi, KS; Shirai, T; Karin, M; Nakanishi, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E177-E186 , 文章类型: Article,,卷期:2012年109-4]
- The decision between survival and death in cells exposed to TNF relies on a highly regulated equilibrium between proapoptotic and antiapoptotic factors. The TNF-activated antiapoptotic response depends on several transcr...
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