- Regulation of CUG-binding Protein 1 (CUGBP1) Binding to Target Transcripts upon T Cell Activation
[作者:Beisang, D; Rattenbacher, B; Vlasova-St Louis, IA; Bohjanen, PR,期刊:Journal of Biological Chemistry, 页码:950-960 , 文章类型: Article,,卷期:2012年287-2]
- The RNA-binding protein, CUG-binding protein 1 (CUGBP1), regulates gene expression at the levels of alternative splicing, mRNA degradation, and translation. We used RNA immunoprecipitation followed by microarray analysis...
- Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin
[作者:Ho, KK; McGuire, VA; Koo, CY; Muir, KW; de Olano, N; Maifoshie, E; Kelly, DJ; McGovern, UB; Monteiro, LJ; Gomes, AR; Nebreda, AR; Campbell, DG; Arthur, JSC; Lam, EWF,期刊:Journal of Biological Chemistry, 页码:1545-1555 , 文章类型: Article,,卷期:2012年287-2]
- FOXO3a is a forkhead transcription factor that regulates a multitude of important cellular processes, including proliferation, apoptosis, differentiation, and metabolism. Doxorubicin treatment of MCF-7 breast carcinoma c...
- Modulation of Heme/Substrate Binding Cleft of Neuronal Nitric-oxide Synthase (nNOS) Regulates Binding of Hsp90 and Hsp70 Proteins and nNOS Ubiquitination
[作者:Peng, HM; Morishima, Y; Pratt, WB; Osawa, Y,期刊:Journal of Biological Chemistry, 页码:1556-1565 , 文章类型: Article,,卷期:2012年287-2]
- Like other nitric-oxide synthase (NOS) enzymes, neuronal NOS (nNOS) turnover and activity are regulated by the Hsp90/Hsp70-based chaperone machinery, which regulates signaling proteins by modulating ligand binding clefts...
- Novel Attributes of Hed1 Affect Dynamics and Activity of the Rad51 Presynaptic Filament during Meiotic Recombination
[作者:Busygina, V; Saro, D; Williams, G; Leung, WK; Say, AF; Sehorn, MG; Sung, P; Tsubouchi, H,期刊:Journal of Biological Chemistry, 页码:1566-1575 , 文章类型: Article,,卷期:2012年287-2]
- During meiosis, recombination events that occur between homologous chromosomes help prepare the chromosome pairs for proper disjunction in meiosis I. The concurrent action of the Rad51 and Dmc1 recombinases is necessary ...
- Phosphatidate Phosphatase Plays Role in Zinc-mediated Regulation of Phospholipid Synthesis in Yeast
[作者:Soto-Cardalda, A; Fakas, S; Pascual, F; Choi, HS; Carman, GM,期刊:Journal of Biological Chemistry, 页码:968-977 , 文章类型: Article,,卷期:2012年287-2]
- In the yeast Saccharomyces cerevisiae, the synthesis of phospholipids is coordinately regulated by mechanisms that control the homeostasis of the essential mineral zinc (Carman, G. M., and Han, G. S. (2007) Regulation of...
- Pro-survival Effects of 17 beta-Estradiol on Osteocytes Are Mediated by Nitric Oxide/cGMP via Differential Actions of cGMP-dependent Protein Kinases I and II
[作者:Marathe, N; Rangaswami, H; Zhuang, SH; Boss, GR; Pilz, RB,期刊:Journal of Biological Chemistry, 页码:978-988 , 文章类型: Article,,卷期:2012年287-2]
- Estrogens promote bone health in part by increasing osteocyte survival, an effect that requires activation of the protein kinases Akt and ERK1/2, but the molecular mechanisms involved are only partly understood. Because ...
- Corneal Antifibrotic Switch Identified in Genetic and Pharmacological Deficiency of Vimentin
[作者:Bargagna-Mohan, P; Paranthan, RR; Hamza, A; Zhan, CG; Lee, DM; Kim, KB; Lau, DL; Srinivasan, C; Nakayama, K; Nakayama, KI; Herrmann, H; Mohan, R,期刊:Journal of Biological Chemistry, 页码:989-1006 , 文章类型: Article,,卷期:2012年287-2]
- The type III intermediate filaments (IFs) are essential cytoskeletal elements of mechanosignal transduction and serve critical roles in tissue repair. Mice genetically deficient for the IF protein vimentin (Vim(-/-)) hav...
- CTRP1 Protein Enhances Fatty Acid Oxidation via AMP-activated Protein Kinase (AMPK) Activation and Acetyl-CoA Carboxylase (ACC) Inhibition
[作者:Peterson, JM; Aja, S; Wei, ZK; Wong, GW,期刊:Journal of Biological Chemistry, 页码:1576-1587 , 文章类型: Article,,卷期:2012年287-2]
- We previously described the adipokine CTRP1, which has up-regulated expression following exposure to the anti-diabetic drug rosiglitazone and increased circulating levels in adiponectin-null mice (Wong, G. W., Krawczyk, ...
- Dissection of Wnt5a-Ror2 Signaling Leading to Matrix Metalloproteinase (MMP-13) Expression
[作者:Yamagata, K; Li, X; Ikegaki, S; Oneyama, C; Okada, M; Nishita, M; Minami, Y,期刊:Journal of Biological Chemistry, 页码:1588-1599 , 文章类型: Article,,卷期:2012年287-2]
- It has been shown that constitutively active Wnt5a-Ror2 signaling in osteosarcoma cell lines plays crucial roles in induced expression of matrix metalloproteinase-13 (MMP-13), required for their invasiveness; however, it...
- Brain-derived Neurotrophic Factor (BDNF) Induces Polarized Signaling of Small GTPase (Rac1) Protein at the Onset of Schwann Cell Myelination through Partitioning-defective 3 (Par3) Protein
[作者:Tep, C; Kim, ML; Opincariu, LI; Limpert, AS; Chan, JR; Appel, B; Carter, BD; Yoon, SO,期刊:Journal of Biological Chemistry, 页码:1600-1608 , 文章类型: Article,,卷期:2012年287-2]
- Brain-derived neurotrophic factor (BDNF) was shown to play a role in Schwann cell myelination by recruiting Par3 to the axon-glial interface, but the underlying mechanism has remained unclear. Here we report that Par3 re...
- Notch and transforming growth factor-beta (TGF beta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation (vol 285, pg 17556, 2010)
[作者:Tang, YF; Urs, S; Boucher, J; Bernaiche, T; Venkatesh, D; Spicer, DB; Vary, CPH; Liaw, L,期刊:Journal of Biological Chemistry, 页码:1609-1609 , 文章类型: Correction,,卷期:2012年287-2]
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- HAMP Domain-mediated Signal Transduction Probed with a Mycobacterial Adenylyl Cyclase as a Reporter
[作者:Mondejar, LG; Lupas, A; Schultz, A; Schultz, JE,期刊:Journal of Biological Chemistry, 页码:1022-1031 , 文章类型: Article,,卷期:2012年287-2]
- HAMP domains, similar to 55 amino acid motifs first identified in histidine kinases, adenylyl cyclases, methyl-accepting chemotaxis proteins, and phosphatases, operate as signal mediators in two-component signal transduc...
- Solution Structure and Molecular Interactions of Lamin B Receptor Tudor Domain
[作者:Liokatis, S; Edlich, C; Soupsana, K; Giannios, I; Panagiotidou, P; Tripsianes, K; Sattler, M; Georgatos, SD; Politou, AS,期刊:Journal of Biological Chemistry, 页码:1032-1042 , 文章类型: Article,,卷期:2012年287-2]
- Lamin B receptor (LBR) is a polytopic protein of the nuclear envelope thought to connect the inner nuclear membrane with the underlying nuclear lamina and peripheral heterochromatin. To better understand the function of ...
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