- Energy-sensing Factors Coactivator Peroxisome Proliferator-activated Receptor gamma Coactivator 1-alpha (PGC-1 alpha) and AMP-activated Protein Kinase Control Expression of Inflammatory Mediators in Liver INDUCTION OF INTERLEUKIN 1 RECEPTOR ANTAGONIST
[作者:Buler, M; Aatsinki, SM; Skoumal, R; Komka, Z; Toth, M; Kerkela, R; Georgiadi, A; Kersten, S; Hakkola, J,期刊:Journal of Biological Chemistry, 页码:1847-1860 , 文章类型: Article,,卷期:2012年287-3]
- Obesity and insulin resistance are associated with chronic, low grade inflammation. Moreover, regulation of energy metabolism and immunity are highly integrated. We hypothesized that energy-sensitive coactivator peroxiso...
- Glucose and Insulin Induction of Bile Acid Synthesis MECHANISMS AND IMPLICATION IN DIABETES AND OBESITY
[作者:Li, TG; Francl, JM; Boehme, S; Ochoa, A; Zhang, YC; Klaassen, CD; Erickson, SK; Chiang, JYL,期刊:Journal of Biological Chemistry, 页码:1861-1873 , 文章类型: Article,,卷期:2012年287-3]
- Bile acids facilitate postprandial absorption of nutrients. Bile acids also activate the farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5 and play a major role in regulating lipid, glucose, and energy m...
- Biochemical and Structural Studies of Uncharacterized Protein PA0743 from Pseudomonas aeruginosa Revealed NAD(+)-dependent L-Serine Dehydrogenase
[作者:Tchigvintsev, A; Singer, A; Brown, G; Flick, R; Evdokimova, E; Tan, KM; Gonzalez, CF; Savchenko, A; Yakunin, AF,期刊:Journal of Biological Chemistry, 页码:1874-1883 , 文章类型: Article,,卷期:2012年287-3]
- The beta-hydroxyacid dehydrogenases form a large family of ubiquitous enzymes that catalyze oxidation of various beta-hydroxy acid substrates to corresponding semialdehydes. Several known enzymes include beta-hydroxyisob...
- Torque Generation and Utilization in Motor Enzyme F0F1-ATP Synthase HALF-TORQUE F-1 WITH SHORT-SIZED PUSHROD HELIX AND REDUCED ATP SYNTHESIS BY HALF-TORQUE F0F1
[作者:Usukura, E; Suzuki, T; Furuike, S; Soga, N; Saita, E; Hisabori, T; Kinosita, K; Yoshida, M,期刊:Journal of Biological Chemistry, 页码:1884-1891 , 文章类型: Article,,卷期:2012年287-3]
- ATP synthase (F0F1) is made of two motors, a proton-driven motor (F-0) and an ATP-driven motor (F-1), connected by a common rotary shaft, and catalyzes proton flow-driven ATP synthesis and ATP-driven proton pumping. In F...
- Novel Mycobacteria Antigen 85 Complex Binding Motif on Fibronectin
[作者:Kuo, CJ; Bell, H; Hsieh, CL; Ptak, CP; Chang, YF,期刊:Journal of Biological Chemistry, 页码:1892-1902 , 文章类型: Article,,卷期:2012年287-3]
- The members of the antigen 85 protein family (Ag85), consisting of members Ag85A, Ag85B, and Ag85C, are the predominantly secreted proteins of mycobacteria and possess the ability to specifically interact with fibronecti...
- Interactions between the Conserved Hydrophobic Region of the Prion Protein and Dodecylphosphocholine Micelles
[作者:Sauve, S; Buijs, D; Gingras, G; Aubin, Y,期刊:Journal of Biological Chemistry, 页码:1915-1922 , 文章类型: Article,,卷期:2012年287-3]
- The three-dimensional structure of PrP110-136, a peptide encompassing the conserved hydrophobic region of the human prion protein, has been determined at high resolution in dodecylphosphocholine micelles by NMR. The resu...
- Pro-nerve Growth Factor Induces Autocrine Stimulation of Breast Cancer Cell Invasion through Tropomyosin-related Kinase A (TrkA) and Sortilin Protein
[作者:Demont, Y; Corbet, C; Page, A; Ataman-Onal, Y; Choquet-Kastylevsky, G; Fliniaux, I; Le Bourhis, X; Toillon, RA; Bradshaw, RA; Hondermarck, H,期刊:Journal of Biological Chemistry, 页码:1923-1931 , 文章类型: Article,,卷期:2012年287-3]
- The precursor of nerve growth factor (proNGF) has been described as a biologically active polypeptide able to induce apoptosis in neuronal cells, via the neurotrophin receptor p75(NTR) and the sortilin receptor. Herein, ...
- Identification of a Key Motif That Determines the Differential Surface Levels of RET and TrkB Tyrosine Kinase Receptors and Controls Depolarization Enhanced RET Surface Insertion
[作者:Li, XZ; Yan, J; Huang, SH; Zhao, L; Wang, J; Chen, ZY,期刊:Journal of Biological Chemistry, 页码:1932-1945 , 文章类型: Article,,卷期:2012年287-3]
- The RET tyrosine kinase receptor plays an important role in the development and maintenance of the nervous system. Although the ligand-induced RET signaling pathway has been well described, little is known about the regu...
- Oleosin Is Bifunctional Enzyme That Has Both Monoacylglycerol Acyltransferase and Phospholipase Activities
[作者:Parthibane, V; Rajakumari, S; Venkateshwari, V; Iyappan, R; Rajasekharan, R,期刊:Journal of Biological Chemistry, 页码:1946-1954 , 文章类型: Article,,卷期:2012年287-3]
- In plants, fatty oils are generally stored in spherical intracellular organelles referred to as oleosomes that are covered by proteins such as oleosin. Seeds with high oil content have more oleosin than those with low oi...
- Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1 alpha (HIF-1 alpha) during Hypoxia
[作者:Altun, M; Zhao, B; Velasco, K; Liu, HY; Hassink, G; Paschke, J; Pereira, T; Lindsten, K,期刊:Journal of Biological Chemistry, 页码:1962-1969 , 文章类型: Article,,卷期:2012年287-3]
- A proper cellular adaptation to low oxygen levels is essential for processes such as development, growth, metabolism, and angiogenesis. The response to decrease in oxygen supply, referred to as hypoxia, is also involved ...
- Dual Beneficial Effect of Interloop Disulfide Bond for Single Domain Antibody Fragments
[作者:Govaert, J; Pellis, M; Deschacht, N; Vincke, C; Conrath, K; Muyldermans, S; Saerens, D,期刊:Journal of Biological Chemistry, 页码:1970-1979 , 文章类型: Article,,卷期:2012年287-3]
- The antigen-binding fragment of functional heavy chain antibodies (HCAbs) in camelids comprises a single domain, named the variable domain of heavy chain of HCAbs (VHH). The VHH harbors remarkable amino acid substitution...
- Consequences of Alteration in Leucine Zipper Sequence of Melittin in Its Neutralization of Lipopolysaccharide-induced Proinflammatory Response in Macrophage Cells and Interaction with Lipopolysaccharide
[作者:Srivastava, RM; Srivastava, S; Singh, M; Bajpai, VK; Ghosh, JK,期刊:Journal of Biological Chemistry, 页码:1980-1995 , 文章类型: Article,,卷期:2012年287-3]
- The bee venom antimicrobial peptide, melittin, besides showing versatile activity against microorganisms also neutralizes lipopolysaccharide (LPS)-induced proinflammatory responses in macrophage cells. However, how the a...
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