- Membrane Estrogen Signaling Enhances Tumorigenesis and Metastatic Potential of Breast Cancer Cells via Estrogen Receptor-alpha 36 (ER alpha 36)
[作者:Chaudhri, RA; Olivares-Navarrete, R; Cuenca, N; Hadadi, A; Boyan, BD; Schwartz, Z,期刊:Journal of Biological Chemistry, 页码:7169-7181 , 文章类型: Article,,卷期:2012年287-10]
- Protein kinase C (PKC) signaling can be activated rapidly by 17 beta-estradiol (E-2) via nontraditional signaling in ER alpha-positive MCF7 and ER alpha-negative HCC38 breast cancer cells and is associated with tumorigen...
- Initial Insights into Structure-Activity Relationships of Avian Defensins
[作者:Derache, C; Meudal, H; Aucagne, V; Mark, KJ; Cadene, M; Delmas, AF; Lalmanach, AC; Landon, C,期刊:Journal of Biological Chemistry, 页码:7746-7755 , 文章类型: Article,,卷期:2012年287-10]
- Numerous beta-defensins have been identified in birds, and the potential use of these peptides as alternatives to antibiotics has been proposed, in particular to fight antibiotic-resistant and zoonotic bacterial species....
- Apoptotic DNA Degradation into Oligonucleosomal Fragments, but Not Apoptotic Nuclear Morphology, Relies on a Cytosolic Pool of DFF40/CAD Endonuclease
[作者:Iglesias-Guimarais, V; Gil-Guinon, E; Gabernet, G; Garcia-Belinchon, M; Sanchez-Osuna, M; Casanelles, E; Comella, JX; Yuste, VJ,期刊:Journal of Biological Chemistry, 页码:7766-7779 , 文章类型: Article,,卷期:2012年287-10]
- Apoptotic cell death is characterized by nuclear fragmentation and oligonucleosomal DNA degradation, mediated by the caspase-dependent specific activation of DFF40/CAD endonuclease. Here, we describe how, upon apoptotic ...
- New Molecular Bridge between RelA/p65 and NF-kappa B Target Genes via Histone Acetyltransferase TIP60 Cofactor
[作者:Kim, JW; Jang, SM; Kim, CH; An, JH; Kang, EJ; Choi, KH,期刊:Journal of Biological Chemistry, 页码:7780-7791 , 文章类型: Article,,卷期:2012年287-10]
- The nuclear factor-kappa B (NF-kappa B) family is involved in the expressions of numerous genes, in development, apoptosis, inflammatory responses, and oncogenesis. In this study we identified four NF-kappa B target gene...
- Structural Analysis of the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Intracellular Domain Reveals a Conserved Interaction Epitope
[作者:Mayer, C; Slater, L; Erat, MC; Konrat, R; Vakonakis, I,期刊:Journal of Biological Chemistry, 页码:7182-7189 , 文章类型: Article,,卷期:2012年287-10]
- Plasmodium falciparum-infected red blood cells adhere to endothelial cells, thereby obstructing the microvasculature. Erythrocyte adherence is directly associated with severe malaria and increased disease lethality, and ...
- Fibronectin Induces Endothelial Cell Migration through beta 1 Integrin and Src-dependent Phosphorylation of Fibroblast Growth Factor Receptor-1 at Tyrosines 653/654 and 766
[作者:Zou, L; Cao, S; Kang, NL; Huebert, RC; Shah, VH,期刊:Journal of Biological Chemistry, 页码:7190-7202 , 文章类型: Article,,卷期:2012年287-10]
- The extracellular matrix microenvironment regulates cell phenotype and function. One mechanism by which this is achieved is the transactivation of receptor tyrosine kinases by specific matrix molecules. Here, we demonstr...
- Structure/Function Analysis of Pasteurella multocida Heparosan Synthases TOWARD DEFINING ENZYME SPECIFICITY AND ENGINEERING NOVEL CATALYSTS
[作者:Otto, NJ; Green, DE; Masuko, S; Mayer, A; Tanner, ME; Linhardt, RJ; DeAngelis, PL,期刊:Journal of Biological Chemistry, 页码:7203-7212 , 文章类型: Article,,卷期:2012年287-10]
- The Pasteurella multocida heparosan synthases, PmHS1 and PmHS2, are homologous (similar to 65% identical) bifunctional glycosyltransferase proteins found in Type D Pasteurella. These unique enzymes are able to generate t...
- Protein Kinase C (PKC) zeta-mediated G alpha(q) Stimulation of ERK5 Protein Pathway in Cardiomyocytes and Cardiac Fibroblasts
[作者:Garcia-Hoz, C; Sanchez-Fernandez, G; Garcia-Escudero, R; Fernandez-Velasco, M; Palacios-Garcia, J; Ruiz-Meana, M; Diaz-Meco, MT; Leitges, M; Moscat, J; Garcia-Dorado, D; Bosca, L; Mayor, F; Ribas, C,期刊:Journal of Biological Chemistry, 页码:7792-7802 , 文章类型: Article,,卷期:2012年287-10]
- Gq-coupled G protein-coupled receptors (GPCRs) mediate the actions of a variety of messengers that are key regulators of cardiovascular function. Enhanced G alpha(q)-mediated signaling plays an important role in cardiac ...
- Low Density Lipoprotein (LDL) Receptor-related Protein 6 (LRP6) Regulates Body Fat and Glucose Homeostasis by Modulating Nutrient Sensing Pathways and Mitochondrial Energy Expenditure
[作者:Liu, WZ; Singh, R; Choi, CS; Lee, HY; Keramati, AR; Samuel, VT; Lifton, RP; Shulman, GI; Mani, A,期刊:Journal of Biological Chemistry, 页码:7213-7223 , 文章类型: Article,,卷期:2012年287-10]
- Body fat, insulin resistance, and type 2 diabetes are often linked together, but the molecular mechanisms that unify their association are poorly understood. Wnt signaling regulates adipogenesis, and its altered activity...
- DHHC Protein S-Acyltransferases Use Similar Ping-Pong Kinetic Mechanisms but Display Different Acyl-CoA Specificities
[作者:Jennings, BC; Linder, ME,期刊:Journal of Biological Chemistry, 页码:7236-7245 , 文章类型: Article,,卷期:2012年287-10]
- DHHCproteins catalyze the reversible S-acylation of proteins at cysteine residues, a modification important for regulating protein localization, stability, and activity. However, little is known about the kinetic mechani...
- Molecular Identification of Hydroxylysine Kinase and of Ammoniophospholyases Acting on 5-Phosphohydroxy-L-lysine and Phosphoethanolamine
[作者:Veiga-da-Cunha, M; Hadi, F; Balligand, T; Stroobant, V; Van Schaftingen, E,期刊:Journal of Biological Chemistry, 页码:7246-7255 , 文章类型: Article,,卷期:2012年287-10]
- The purpose of the present work was to identify the catalytic activity of AGXT2L1 and AGXT2L2, two closely related, putative pyridoxal-phosphate-dependent enzymes encoded by vertebrate genomes. The existence of bacterial...
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