- Macrophage Mesenchymal Migration Requires Podosome Stabilization by Filamin A
[作者:Guiet, R; Verollet, C; Lamsoul, I; Cougoule, C; Poincloux, R; Labrousse, A; Calderwood, DA; Glogauer, M; Lutz, PG; Maridonneau-Parini, I,期刊:Journal of Biological Chemistry, 页码:13051-13062 , 文章类型: Article,,卷期:2012年287-16]
- Filamin A (FLNa) is a cross-linker of actin filaments and serves as a scaffold protein mostly involved in the regulation of actin polymerization. It is distributed ubiquitously, and null mutations have strong consequence...
- Characterization of Heparin-binding Site of Tissue Transglutaminase ITS IMPORTANCE IN CELL SURFACE TARGETING, MATRIX DEPOSITION, AND CELL SIGNALING
[作者:Wang, Z; Collighan, RJ; Pytel, K; Rathbone, DL; Li, XL; Griffin, M,期刊:Journal of Biological Chemistry, 页码:13063-13083 , 文章类型: Article,,卷期:2012年287-16]
- Tissue transglutaminase (TG2) is a multifunctional Ca2+-activated protein cross-linking enzyme secreted into the extracellular matrix (ECM), where it is involved in wound healing and scarring, tissue fibrosis, celiac dis...
- Cardiac Lineage Protein-1 (CLP-1) Regulates Cardiac Remodeling via Transcriptional Modulation of Diverse Hypertrophic and Fibrotic Responses and Angiotensin II-transforming Growth Factor beta (TGF-beta 1) Signaling Axis
[作者:Mascareno, E; Galatioto, J; Rozenberg, I; Salciccioli, L; Kamran, H; Lazar, JM; Liu, F; Pedrazzini, T; Siddiqui, MAQ,期刊:Journal of Biological Chemistry, 页码:13084-13093 , 文章类型: Article,,卷期:2012年287-16]
- It is well known that the renin-angiotensin system contributes to left ventricular hypertrophy and fibrosis, a major determinant of myocardial stiffness. TGF-beta 1 and renin-angiotensin system signaling alters the fibro...
- Phosphatidylinositol 5-Phosphatase Oculocerebrorenal Syndrome of Lowe Protein (OCRL) Controls Actin Dynamics during Early Steps of Listeria monocytogenes Infection
[作者:Kuhbacher, A; Dambournet, D; Echard, A; Cossart, P; Pizarro-Cerda, J,期刊:Journal of Biological Chemistry, 页码:13128-13136 , 文章类型: Article,,卷期:2012年287-16]
- Listeria monocytogenes is a bacterial pathogen that induces its own entry into a broad range of mammalian cells through interaction of the bacterial surface protein InlB with the cellular receptor Met, promoting an actin...
- Molecular Basis for Failure of "Atypical" C1 Domain of Vav1 to Bind Diacylglycerol/Phorbol Ester
[作者:Geczy, T; Peach, ML; El Kazzouli, S; Sigano, DM; Kang, JH; Valle, CJ; Selezneva, J; Woo, W; Kedei, N; Lewin, NE; Garfield, SH; Lim, L; Mannan, P; Marquez, VE; Blumberg, PM,期刊:Journal of Biological Chemistry, 页码:13137-13158 , 文章类型: Article,,卷期:2012年287-16]
- C1 domains, the recognition motif of the second messenger diacylglycerol and of the phorbol esters, are classified as typical (ligand-responsive) or atypical (not ligand-responsive). The C1 domain of Vav1, a guanine nucl...
- Novel Bacterial Lipoprotein Structures Conserved in Low-GC Content Gram-positive Bacteria Are Recognized by Toll-like Receptor 2
[作者:Kurokawa, K; Ryu, KH; Ichikawa, R; Masuda, A; Kim, MS; Lee, H; Chae, JH; Shimizu, T; Saitoh, T; Kuwano, K; Akira, S; Dohmae, N; Nakayama, H; Lee, BL,期刊:Journal of Biological Chemistry, 页码:13170-13181 , 文章类型: Article,,卷期:2012年287-16]
- Bacterial lipoproteins/lipopeptides inducing host innate immune responses are sensed by mammalian Toll-like receptor 2 (TLR2). These bacterial lipoproteins are structurally divided into two groups, diacylated or triacyla...
- Targeted Gene Inactivation of Calpain-1 Suppresses Cortical Degeneration Due to Traumatic Brain Injury and Neuronal Apoptosis Induced by Oxidative Stress
[作者:Yamada, KH; Kozlowski, DA; Seidl, SE; Lance, S; Wieschhaus, AJ; Sundivakkam, P; Tiruppathi, C; Chishti, I; Herman, IM; Kuchay, SM; Chishti, AH,期刊:Journal of Biological Chemistry, 页码:13182-13193 , 文章类型: Article,,卷期:2012年287-16]
- Calpains are calcium-regulated cysteine proteases that have been implicated in the regulation of cell death pathways. Here, we used our calpain-1 null mouse model to evaluate the function of calpain-1 in neural degenerat...
- Interferon Regulatory Factor 1 Transactivates Expression of Human DNA Polymerase eta in Response to Carcinogen N-Methyl-N '-nitro-N-nitrosoguanidine
[作者:Qi, HY; Zhu, HF; Lou, M; Fan, YF; Liu, H; Shen, J; Li, ZJ; Lv, X; Shan, JZ; Zhu, LJ; Chin, YE; Shao, JM,期刊:Journal of Biological Chemistry, 页码:12622-12633 , 文章类型: Article,,卷期:2012年287-16]
- DNA polymerase eta (Pol eta) implements translesion DNA synthesis but has low fidelity in replication. We have previously shown that Pol eta plays an important role in the genesis of non-targeted mutations at undamaged D...
- Structure and Mechanistic Insights into Novel Iron-mediated Moonlighting Functions of Human J-protein Cochaperone, Dph4
[作者:Thakur, A; Chitoor, B; Goswami, AV; Pareek, G; Atreya, HS; D'Silva, P,期刊:Journal of Biological Chemistry, 页码:13194-13205 , 文章类型: Article,,卷期:2012年287-16]
- J-proteins are obligate cochaperones of Hsp70s and stimulate their ATPase activity via the J-domain. Although the functions of J-proteins have been well understood in the context of Hsp70s, their additional co-evolved "p...
- Gekko-sulfated Glycopeptide Inhibits Tumor Angiogenesis by Targeting Basic Fibroblast Growth Factor
[作者:Zhang, SX; Zhu, C; Ba, Y; Chen, D; Zhou, XL; Cao, R; Wang, LP; Ren, Y; Wu, XZ,期刊:Journal of Biological Chemistry, 页码:13206-13215 , 文章类型: Article,,卷期:2012年287-16]
- Basic fibroblast growth factor (bFGF) is a therapeutic target of anti-angiogenesis. Here, we report that a novel sulfated glycopeptide derived from Gekko swinhonis Guenther (GSPP), an anticancer drug in traditional Chine...
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