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  • Generation of HIV Latency in Humanized BLT Mice
    [作者:Denton, PW; Olesen, R; Choudhary, SK; Archin, NM; Wahl, A; Swanson, MD; Chateau, M; Nochi, T; Krisko, JF; Spagnuolo, RA; Margolis, DM; Garcia, JV,期刊:Journal of virology, 页码:630-634 , 文章类型: Article,,卷期:2012年86-1]
  • Here we demonstrate that a combination of tenofovir, emtricitabine, and raltegravir effectively suppresses peripheral and systemic HIV replication in humanized BLT mice. We also demonstrate that antiretroviral therapy (A...
  • HIV Latency in the Humanized BLT Mouse
    [作者:Marsden, MD; Kovochich, M; Suree, N; Shimizu, S; Mehta, R; Cortado, R; Bristol, G; An, DS; Zack, JA,期刊:Journal of virology, 页码:339-347 , 文章类型: Article,,卷期:2012年86-1]
  • Even after extended treatment with powerful antiretroviral drugs, HIV is not completely eliminated from infected individuals. Latently infected CD4(+) T cells constitute one reservoir of replication-competent HIV that ne...