- The Oral Secretion of Infectious Scrapie Prions Occurs in Preclinical Sheep with a Range of PRNP Genotypes
[作者:Gough, KC; Baker, CA; Rees, HC; Terry, LA; Spiropoulos, J; Thorne, L; Maddison, BC,期刊:Journal of virology, 页码:566-571 , 文章类型: Article,,卷期:2012年86-1]
- Preclinical sheep with the highly scrapie-susceptible VRQ/VRQ PRNP genotype secrete prions from the oral cavity. In order to further understand the significance of orally available prions, buccal swabs were taken from sh...
- Epstein-Barr Virus Isolates Retain Their Capacity To Evade T Cell Immunity through BNLF2a despite Extensive Sequence Variation
[作者:Horst, D; Burrows, SR; Gatherer, D; van Wilgenburg, B; Bell, MJ; Boer, IGJ; Ressing, ME; Wiertz, EJHJ,期刊:Journal of virology, 页码:572-577 , 文章类型: Article,,卷期:2012年86-1]
- The Epstein-Barr virus (EBV)-encoded immune evasion protein BNLF2a inhibits the transporter associated with antigen processing (TAP), thereby downregulating HLA class I expression at the cell surface. As a consequence, r...
- Conditional CD8(+) T Cell Escape during Acute Simian Immunodeficiency Virus Infection
[作者:O'Connor, SL; Becker, EA; Weinfurter, JT; Chin, EN; Budde, ML; Gostick, E; Correll, M; Gleicher, M; Hughes, AL; Price, DA; Friedrich, TC; O'Connor, DH,期刊:Journal of virology, 页码:605-609 , 文章类型: Article,,卷期:2012年86-1]
- CD8(+) T cell responses rapidly select viral variants during acute human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection. We used pyrosequencing to examine variation within three SIV-derived ep...
- Recent Mumps Outbreaks in Vaccinated Populations: No Evidence of Immune Escape
[作者:Rubin, SA; Link, MA; Sauder, CJ; Zhang, C; Ngo, L; Rima, BK; Duprex, WP,期刊:Journal of virology, 页码:615-620 , 文章类型: Article,,卷期:2012年86-1]
- Recently, numerous large-scale mumps outbreaks have occurred in vaccinated populations. Clinical isolates sequenced from these outbreaks have invariably been of genotypes distinct from those of vaccine viruses, raising c...
- Viral Expression Directs the Fate of B Cells in Bovine Leukemia Virus-Infected Sheep
[作者:Florins, A; de Brogniez, A; Elemans, M; Bouzar, AB; Francois, C; Reichert, M; Asquith, B; Willems, L,期刊:Journal of virology, 页码:621-624 , 文章类型: Article,,卷期:2012年86-1]
- The host immune response is believed to tightly control viral replication of deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV). However, this assumption has not been def...
- Adenovirus Serotype 5 Neutralizing Antibodies Target both Hexon and Fiber following Vaccination and Natural Infection
[作者:Bradley, RR; Lynch, DM; Iampietro, MJ; Borducchi, EN; Barouch, DH,期刊:Journal of virology, 页码:625-629 , 文章类型: Article,,卷期:2012年86-1]
- The immunogenicity of adenovirus serotype 5 (Ad5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against the hexon hypervariable regions (HVRs). However, the role of NAbs dir...
- Generation of HIV Latency in Humanized BLT Mice
[作者:Denton, PW; Olesen, R; Choudhary, SK; Archin, NM; Wahl, A; Swanson, MD; Chateau, M; Nochi, T; Krisko, JF; Spagnuolo, RA; Margolis, DM; Garcia, JV,期刊:Journal of virology, 页码:630-634 , 文章类型: Article,,卷期:2012年86-1]
- Here we demonstrate that a combination of tenofovir, emtricitabine, and raltegravir effectively suppresses peripheral and systemic HIV replication in humanized BLT mice. We also demonstrate that antiretroviral therapy (A...
- Characterization, Mapping, and Distribution of the Two XMRV Parental Proviruses
[作者:Cingoz, O; Paprotka, T; Delviks-Frankenberry, KA; Wildt, S; Hu, WS; Pathak, VK; Coffin, JM,期刊:Journal of virology, 页码:328-338 , 文章类型: Article,,卷期:2012年86-1]
- Xenotropic murine leukemia virus-related virus (XMRV) was previously reported to be associated with human prostate cancer and chronic fatigue syndrome. Our groups recently showed that XMRV was created through recombinati...
- HIV Latency in the Humanized BLT Mouse
[作者:Marsden, MD; Kovochich, M; Suree, N; Shimizu, S; Mehta, R; Cortado, R; Bristol, G; An, DS; Zack, JA,期刊:Journal of virology, 页码:339-347 , 文章类型: Article,,卷期:2012年86-1]
- Even after extended treatment with powerful antiretroviral drugs, HIV is not completely eliminated from infected individuals. Latently infected CD4(+) T cells constitute one reservoir of replication-competent HIV that ne...
- Pestivirus Virion Morphogenesis in the Absence of Uncleaved Nonstructural Protein 2-3
[作者:Lattwein, E; Klemens, O; Schwindt, S; Becher, P; Tautz, N,期刊:Journal of virology, 页码:427-437 , 文章类型: Article,,卷期:2012年86-1]
- The family Flaviviridae contains three genera of positive-strand RNA viruses, namely, Flavivirus, Hepacivirus (e.g., hepatitis C virus [HCV]), and Pestivirus. Pestiviruses, like bovine viral diarrhea virus (BVDV), bear a...
- Five Genome Sequences of Subspecies B1 Human Adenoviruses Associated with Acute Respiratory Disease
[作者:Dehghan, S; Liu, EB; Seto, J; Torres, SF; Hudson, NR; Kajon, AE; Metzgar, D; Dyer, DW; Chodosh, J; Jones, MS; Seto, D,期刊:Journal of virology, 页码:635-636 , 文章类型: Article,,卷期:2012年86-1]
- Five genomes of human subspecies B1 adenoviruses isolated from cases of acute respiratory disease have been sequenced and archived for reference. These include representatives of two prevalent genomic variants of HAdV-7,...
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