- Small Rho GTPases and Cholesterol Biosynthetic Pathway Intermediates in African Swine Fever Virus Infection
[作者:Quetglas, JI; Hernaez, B; Galindo, I; Munoz-Moreno, R; Cuesta-Geijo, MA; Alonso, C,期刊:Journal of virology, 页码:1758-1767 , 文章类型: Article,,卷期:2012年86-3]
- The integrity of the cholesterol biosynthesis pathway is required for efficient African swine fever virus (ASFV) infection. Incorporation of prenyl groups into Rho GTPases plays a key role in several stages of ASFV infec...
- Inoculation of Swine with Foot-and-Mouth Disease SAP-Mutant Virus Induces Early Protection against Disease
[作者:Segundo, FDS; Weiss, M; Perez-Martin, E; Dias, CC; Grubman, MJ; de los Santos, T,期刊:Journal of virology, 页码:1316-1327 , 文章类型: Article,,卷期:2012年86-3]
- Foot-and-mouth disease virus (FMDV) leader proteinase (L(pro)) cleaves itself from the viral polyprotein and cleaves the translation initiation factor eIF4G. As a result, host cell translation is inhibited, affecting the...
- Critical Role for Voltage-Dependent Anion Channel 2 in Infectious Bursal Disease Virus-Induced Apoptosis in Host Cells via Interaction with VP5
[作者:Li, ZH; Wang, YQ; Xue, YF; Li, XQ; Cao, H; Zheng, SJJ,期刊:Journal of virology, 页码:1328-1338 , 文章类型: Article,,卷期:2012年86-3]
- Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). Although IBDV-induced host cell apoptosis has been established, the underlying molecular mec...
- The V Protein of Mumps Virus Plays a Critical Role in Pathogenesis
[作者:Xu, P; Luthra, P; Li, Z; Fuentes, S; D'Andrea, JA; Wu, JG; Rubin, S; Rota, PA; He, BA,期刊:Journal of virology, 页码:1768-1776 , 文章类型: Article,,卷期:2012年86-3]
- Mumps virus (MuV) causes an acute infection in humans characterized by a wide array of symptoms ranging from relatively mild manifestations, such as parotitis, to more-severe complications, such as meningitis and encepha...
- Accelerated Shedding of Prions following Damage to the Olfactory Epithelium
[作者:Bessen, RA; Wilham, JM; Lowe, D; Watschke, CP; Shearin, H; Martinka, S; Caughey, B; Wiley, JA,期刊:Journal of virology, 页码:1777-1788 , 文章类型: Article,,卷期:2012年86-3]
- In this study, we investigated the role of damage to the nasal mucosa in the shedding of prions into nasal samples as a pathway for prion transmission. Here, we demonstrate that prions can replicate to high levels in the...
- Human Annexin A6 Interacts with Influenza A Virus Protein M2 and Negatively Modulates Infection
[作者:Ma, HL; Kien, F; Maniere, M; Zhang, Y; Lagarde, N; Tse, KS; Poon, LLM; Nal, B,期刊:Journal of virology, 页码:1789-1801 , 文章类型: Article,,卷期:2012年86-3]
- The influenza A virus M2 ion channel protein has the longest cytoplasmic tail (CT) among the three viral envelope proteins and is well conserved between different viral strains. It is accessible to the host cellular mach...
- Increased Susceptibility to DNA Virus Infection in Mice with a GCN2 Mutation
[作者:Won, S; Eidenschenk, C; Arnold, CN; Siggs, OM; Sun, L; Brandl, K; Mullen, TM; Nemerow, GR; Moresco, EMY; Beutler, B,期刊:Journal of virology, 页码:1802-1808 , 文章类型: Article,,卷期:2012年86-3]
- The downregulation of translation through eIF2 alpha phosphorylation is a cellular response to diverse stresses, including viral infection, and is mediated by the GCN2 kinase, protein kinase R (PKR), protein kinase-like ...
- Distinct Domains in ORF52 Tegument Protein Mediate Essential Functions in Murine Gammaherpesvirus 68 Virion Tegumentation and Secondary Envelopment
[作者:Wang, LL; Guo, HT; Reyes, N; Lee, SY; Bortz, E; Guo, FL; Sun, R; Tong, L; Deng, HY,期刊:Journal of virology, 页码:1348-1357 , 文章类型: Article,,卷期:2012年86-3]
- Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are etiologically associated with several types of human malignancies. However, as these two human gammaherpesviruses do not replicate efficiently in culture...
- Kaposi's Sarcoma-Associated Herpesvirus-Encoded MicroRNA miR-K12-11 Attenuates Transforming Growth Factor Beta Signaling through Suppression of SMAD5
[作者:Liu, YH; Sun, R; Lin, XZ; Liang, DG; Deng, Q; Lan, K,期刊:Journal of virology, 页码:1372-1381 , 文章类型: Article,,卷期:2012年86-3]
- Kaposi's sarcoma-associated herpesvirus (KSHV) encodes 12 pre-microRNAs (pre-miRNAs). Current studies have shown that these miRNAs are involved in regulation of viral and host gene expression, implicating a role in the m...
- Binding of Anti-Membrane-Proximal gp41 Monoclonal Antibodies to CD4-Liganded and -Unliganded Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Virions
[作者:Rathinakumar, R; Dutta, M; Zhu, P; Johnson, WE; Roux, KH,期刊:Journal of virology, 页码:1820-1831 , 文章类型: Article,,卷期:2012年86-3]
- The broadly neutralizing monoclonal antibodies (MAbs) 4E10, 2F5, and Z13e1 target membrane-proximal external region (MPER) epitopes of HIV-1 gp41 in a manner that remains controversial. The requirements for initial lipid...
- Cholesterol-Rich Microdomains as Docking Platforms for Respiratory Syncytial Virus in Normal Human Bronchial Epithelial Cells
[作者:San-Juan-Vergara, H; Sampayo-Escobar, V; Reyes, N; Cha, B; Pacheco-Lugo, L; Wong, T; Peeples, ME; Collins, PL; Castano, ME; Mohapatra, SS,期刊:Journal of virology, 页码:1832-1843 , 文章类型: Article,,卷期:2012年86-3]
- Respiratory syncytial virus (RSV) is one of the major causes of respiratory infections in children, and it is the main pathogen causing bronchiolitis in infants. The binding and entry mechanism by which RSV infects respi...
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