- Air1 Zinc Knuckles 4 and 5 and a Conserved IWRXY Motif Are Critical for the Function and Integrity of the Trf4/5-Air1/2-Mtr4 Polyadenylation (TRAMP) RNA Quality Control Complex
[作者:Fasken, MB; Leung, SW; Banerjee, A; Kodani, MO; Chavez, R; Bowman, EA; Purohit, MK; Rubinson, ME; Rubinson, EH; Corbett, AH,期刊:Journal of Biological Chemistry, 页码:37429-37445 , 文章类型: Article,,卷期:2011年286-43]
- In Saccharomyces cerevisiae, non-coding RNAs, including cryptic unstable transcripts (CUTs), are subject to degradation by the exosome. The Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) complex in S. cerevisiae is a nuclear...
- Structural Switching of Staphylococcus aureus Clp Protease A KEY TO UNDERSTANDING PROTEASE DYNAMICS
[作者:Zhang, J; Ye, F; Lan, LF; Jiang, HL; Luo, C; Yang, CG,期刊:Journal of Biological Chemistry, 页码:37590-37601 , 文章类型: Article,,卷期:2011年286-43]
- ATP-dependent Clp protease (ClpP) is an attractive new target for the development of anti-infective agents. The ClpP protease consists of two heptameric rings that enclose a large chamber containing 14 proteolytic active...
- The RhoG/ELMO1/Dock180 Signaling Module Is Required for Spine Morphogenesis in Hippocampal Neurons
[作者:Kim, JY; Oh, MH; Bernard, LP; Macara, IG; Zhang, HY,期刊:Journal of Biological Chemistry, 页码:37615-37624 , 文章类型: Article,,卷期:2011年286-43]
- Dendritic spines are actin-rich structures, the formation and plasticity of which are regulated by the Rho GTPases in response to synaptic input. Although several guanine nucleotide exchange factors (GEFs) have been impl...
- The Endosomal Na(+)/H(+) Exchanger Contributes to Multivesicular Body Formation by Regulating the Recruitment of ESCRT-0 Vps27p to the Endosomal Membrane
[作者:Mitsui, K; Koshimura, Y; Yoshikawa, Y; Matsushita, M; Kanazawa, H,期刊:Journal of Biological Chemistry, 页码:37625-37638 , 文章类型: Article,,卷期:2011年286-43]
- Multivesicular bodies (MVBs) are late endosomal compartments containing luminal vesicles (MVB vesicles) that are formed by inward budding of the endosomal membrane. In budding yeast, MVBs are an important cellular mechan...
- BRI2 Protein Regulates beta-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE)
[作者:Kilger, E; Buehler, A; Woelfing, H; Kumar, S; Kaeser, SA; Nagarathinam, A; Walter, J; Jucker, M; Coomaraswamy, J,期刊:Journal of Biological Chemistry, 页码:37446-37457 , 文章类型: Article,,卷期:2011年286-43]
- The amyloid precursor protein (APP) is one of the major proteins involved in Alzheimer disease (AD). Proteolytic cleavage of APP gives rise to amyloid-beta (A beta) peptides that aggregate and deposit extensively in the ...
- Overexpression of KLF15 Transcription Factor in Adipocytes of Mice Results in Down-regulation of SCD1 Protein Expression in Adipocytes and Consequent Enhancement of Glucose-induced Insulin Secretion
[作者:Nagare, T; Sakaue, H; Matsumoto, M; Cao, YH; Inagaki, K; Sakai, M; Takashima, Y; Nakamura, K; Mori, T; Okada, Y; Matsuki, Y; Watanabe, E; Ikeda, K; Taguchi, R; Kamimura, N; Ohta, S; Hiramatsu, R; Kasuga, M,期刊:Journal of Biological Chemistry, 页码:37458-37469 , 文章类型: Article,,卷期:2011年286-43]
- Kruppel-like factor 15 (KLF15), a member of the Kruppel-like factor family of transcription factors, has been found to play diverse roles in adipocytes in vitro. However, little is known of the function of KLF15 in adipo...
- Mixed Lineage Kinase 3 Modulates beta-Catenin Signaling in Cancer Cells
[作者:Thylur, RP; Senthivinayagam, S; Campbell, EM; Rangasamy, V; Thorenoor, N; Sondarva, G; Mehrotra, S; Mishra, P; Zook, E; Le, PT; Rana, A; Rana, B,期刊:Journal of Biological Chemistry, 页码:37470-37482 , 文章类型: Article,,卷期:2011年286-43]
- Expression of beta-catenin is strictly regulated in normal cells via the glycogen synthase kinase 3 beta (GSK3 beta)-adenomatous polyposis coli-axin-mediated degradation pathway. Mechanisms leading to inactivation of thi...
- p53-independent Epigenetic Repression of the p21(WAF1) Gene in T-cell Acute Lymphoblastic Leukemia
[作者:Davies, C; Hogarth, LA; Dietrich, PA; Bachmann, PS; Mackenzie, KL; Hall, AG; Lock, RB,期刊:Journal of Biological Chemistry, 页码:37639-37650 , 文章类型: Article,,卷期:2011年286-43]
- The p53 protein is a primary mediator of cellular apoptosis and growth arrest after exposure to DNA-damaging agents. Previous work has shown that the majority of childhood acute lymphoblastic leukemia (ALL) cases express...
- Cohen Syndrome-associated Protein, COH1, Is a Novel, Giant Golgi Matrix Protein Required for Golgi Integrity
[作者:Seifert, W; Kuhnisch, J; Maritzen, T; Horn, D; Haucke, V; Hennies, HC,期刊:Journal of Biological Chemistry, 页码:37665-37675 , 文章类型: Article,,卷期:2011年286-43]
- Loss-of-function mutations in the gene COH1, also known as VPS13B, lead to autosomal recessive Cohen syndrome. However, the cellular distribution and function of the encoded protein COH1 ( 3997 amino acids), which lacks ...
- Human 1-Acylglycerol-3-phosphate O-Acyltransferase Isoforms 1 and 2 BIOCHEMICAL CHARACTERIZATION AND INABILITY TO RESCUE HEPATIC STEATOSIS IN Agpat2(-/-) GENE LIPODYSTROPHIC MICE
[作者:Agarwal, AK; Sukumaran, S; Cortes, VA; Tunison, K; Mizrachi, D; Sankella, S; Gerard, RD; Horton, JD; Garg, A,期刊:Journal of Biological Chemistry, 页码:37676-37691 , 文章类型: Article,,卷期:2011年286-43]
- Loss-of-function mutations in 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) 2 in humans and mice result in loss of both the white and brown adipose tissues from birth. AGPAT2 generates precursors for the synthesis...
- Modification of Histones by Sugar beta-N-Acetylglucosamine (GlcNAc) Occurs on Multiple Residues, Including Histone H3 Serine 10, and Is Cell Cycle-regulated
[作者:Zhang, SS; Roche, K; Nasheuer, HP; Lowndes, NF,期刊:Journal of Biological Chemistry, 页码:37483-37495 , 文章类型: Article,,卷期:2011年286-43]
- The monosaccharide, beta-N-acetylglucosamine (GlcNAc), can be added to the hydroxyl group of either serines or threonines to generate an O-linked beta-N-acetylglucosamine (O-GlcNAc) residue (Love, D. C., and Hanover, J. ...
- Conformational Dynamics of Wild-type Lys-48-linked Diubiquitin in Solution
[作者:Hirano, T; Serve, O; Yagi-Utsumi, M; Takemoto, E; Hiromoto, T; Satoh, T; Mizushima, T; Kato, K,期刊:Journal of Biological Chemistry, 页码:37496-37502 , 文章类型: Article,,卷期:2011年286-43]
- Proteasomal degradation is mediated through modification of target proteins by Lys-48-linked polyubiquitin (polyUb) chain, which interacts with several binding partners in this pathway through hydrophobic surfaces on ind...
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