- Transcriptomic resilience to global warming in the seagrass Zostera marina, a marine foundation species
[作者:Franssen, SU; Gu, J; Bergmann, N; Winters, G; Klostermeier, UC; Rosenstiel, P; Bornberg-Bauer, E; Reusch, TBH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19276-19281 , 文章类型: Article,,卷期:2011年108-48]
- Large-scale transcription profiling via direct cDNA sequencing provides important insights as to how foundation species cope with increasing climatic extremes predicted under global warming. Species distributed along a t...
- Social network models predict movement and connectivity in ecological landscapes
[作者:Fletcher, RJ; Acevedo, MA; Reichert, BE; Pias, KE; Kitchens, WM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19282-19287 , 文章类型: Article,,卷期:2011年108-48]
- Network analysis is on the rise across scientific disciplines because of its ability to reveal complex, and often emergent, patterns and dynamics. Nonetheless, a growing concern in network analysis is the use of limited ...
- Nonlinear response of summer temperature to Holocene insolation forcing in Alaska
[作者:Clegg, BF; Kelly, R; Clarke, GH; Walker, IR; Hu, FS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19299-19304 , 文章类型: Article,,卷期:2011年108-48]
- Regional climate responses to large-scale forcings, such as precessional changes in solar irradiation and increases in anthropogenic greenhouse gases, may be nonlinear as a result of complex interactions among earth syst...
- Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
[作者:Kobayashi, M; Sabouri, Z; Sabouri, S; Kitawaki, Y; Pommier, Y; Abe, T; Kiyonari, H; Honjo, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19305-19310 , 文章类型: Article,,卷期:2011年108-48]
- Somatic hypermutation (SHM) and class-switch recombination (CSR) of the Ig gene require both the transcription of the locus and the expression of activation-induced cytidine deaminase (AID). During CSR, AID decreases the...
- Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli
[作者:Gon, S; Napolitano, R; Rocha, W; Coulon, S; Fuchs, RP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19311-19316 , 文章类型: Article,,卷期:2011年108-48]
- Exposure of Escherichia coli to UV light increases expression of NrdAB, the major ribonucleotide reductase leading to a moderate increase in dNTP levels. The role of elevated dNTP levels during translesion synthesis (TLS...
- Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells
[作者:Baschant, U; Frappart, L; Rauchhaus, U; Bruns, L; Reichardt, HM; Kamradt, T; Brauer, R; Tuckermann, JP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19317-19322 , 文章类型: Article,,卷期:2011年108-48]
- Despite several side effects, glucocorticoids (GCs) have been widely used for 60 y to treat rheumatoid arthritis on the basis of their antiinflammatory effects. However, the cells targeted by GCs and the transcriptional ...
- Basic residues in the T-cell receptor zeta cytoplasmic domain mediate membrane association and modulate signaling
[作者:Zhang, H; Cordoba, SP; Dushek, O; van der Merwe, PA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19323-19328 , 文章类型: Article,,卷期:2011年108-48]
- The T-cell receptor (TCR) consists of a TCR alpha beta heterodimer, a TCR zeta homodimer, and CD3 gamma epsilon and CD3 delta epsilon heterodimers. The precise mechanism of T-cell triggering following TCR ligand engageme...
- Conformational lability in the class II MHC 3(10) helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange
[作者:Painter, CA; Negroni, MP; Kellersberger, KA; Zavala-Ruiz, Z; Evans, JE; Stern, LJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19329-19334 , 文章类型: Article,,卷期:2011年108-48]
- HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA-DR1 by substitution of alpha F54, resulting ...
- Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system
[作者:Huang, SX; Cheng, TY; Young, DC; Layre, E; Madigan, CA; Shires, J; Cerundolo, V; Altman, JD; Moody, DB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19335-19340 , 文章类型: Article,,卷期:2011年108-48]
- Unlike the dominant role of one class II invariant chain peptide (CLIP) in blocking MHC class II, comparative lipidomics analysis shows that human cluster of differentiation (CD) proteins CD1a, CD1b, CD1c, and CD1d bind ...
- Tripartite motif 8 (TRIM8) modulates TNF alpha- and IL-1 beta-triggered NF-kappa B activation by targeting TAK1 for K63-linked polyubiquitination
[作者:Li, Q; Yan, J; Mao, AP; Li, C; Ran, Y; Shu, HB; Wang, YY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19341-19346 , 文章类型: Article,,卷期:2011年108-48]
- The tripartite motif (TRIM)-containing proteins are a family of proteins that have been known to be involved in divergent biological processes, including important roles in immune responses through regulating various sig...
- In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles
[作者:Chan, JM; Rhee, JW; Drum, CL; Bronson, RT; Golomb, G; Langer, R; Farokhzad, OC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19347-19352 , 文章类型: Article,,卷期:2011年108-48]
- Following recent successes with percutaneous coronary intervention (PCI) for treating coronary artery disease (CAD), many challenges remain. In particular, mechanical injury from the procedure results in extensive endoth...
- Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions
[作者:Pitzer, VE; Patel, MM; Lopman, BA; Viboud, C; Parashar, UD; Grenfell, BT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19353-19358 , 文章类型: Article,,卷期:2011年108-48]
- Understanding how immunity shapes the dynamics of multistrain pathogens is essential in determining the selective pressures imposed by vaccines. There is currently much interest in elucidating the strain dynamics of rota...
- Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans
[作者:Bahl, J; Nelson, MI; Chan, KH; Chen, RB; Vijaykrishna, D; Halpin, RA; Stockwell, TB; Lin, XD; Wentworth, DE; Ghedin, E; Guan, Y; Peiris, JSM; Riley, S; Rambaut, A; Holmes, EC; Smith, GJD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19359-19364 , 文章类型: Article,,卷期:2011年108-48]
- Populations of seasonal influenza virus experience strong annual bottlenecks that pose a considerable extinction risk. It has been suggested that an influenza source population located in tropical Southeast or East Asia ...
- Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding
[作者:Hastie, KM; Liu, T; Li, S; King, LB; Ngo, N; Zandonatti, MA; Woods, VL; de la Torre, JC; Saphire, EO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19365-19370 , 文章类型: Article,,卷期:2011年108-48]
- Arenaviruses cause disease in industrialized and developing nations alike. Among them, the hemorrhagic fever virus Lassa is responsible for similar to 300,000-500,000 infections/y in Western Africa. The arenavirus nucleo...
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