- Antagonistic gene transcripts regulate adaptation to new growth environments
[作者:Baumgartner, BL; Bennett, MR; Ferry, M; Johnson, TL; Tsimring, LS; Hasty, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21087-21092 , 文章类型: Article,,卷期:2011年108-52]
- Cells have evolved complex regulatory networks that reorganize gene expression patterns in response to changing environmental conditions. These changes often involve redundant mechanisms that affect various levels of gen...
- Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets
[作者:Agostini, M; Tucci, P; Killick, R; Candi, E; Sayan, BS; Cervo, PRD; Nicotera, P; McKeon, F; Knight, RA; Mak, TW; Melino, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21093-21098 , 文章类型: Article,,卷期:2011年108-52]
- The p53-family member TAp73 is a transcription factor that plays a key role in many biological processes. Here, we show that p73 drives the expression of microRNA (miR)-34a, but not miR-34b and -c, by acting on specific ...
- microRNA-34a regulates neurite outgrowth, spinal morphology, and function
[作者:Agostini, M; Tucci, P; Steinert, JR; Shalom-Feuerstein, R; Rouleau, M; Aberdam, D; Forsythe, ID; Young, KW; Ventura, A; Concepcion, CP; Han, YC; Candi, E; Knight, RA; Mak, TW; Melino, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21099-21104 , 文章类型: Article,,卷期:2011年108-52]
- The p53 family member TAp73 is a transcription factor that plays a key role in many biological processes, including neuronal development. In particular, we have shown that p73 drives the expression of miR-34a, but not mi...
- Discovery of a phenotypic switch regulating sexual mating in the opportunistic fungal pathogen Candida tropicalis
[作者:Porman, AM; Alby, K; Hirakawa, MP; Bennett, RJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21158-21163 , 文章类型: Article,,卷期:2011年108-52]
- Sexual reproduction can promote genetic diversity in eukaryotes, and yet many pathogenic fungi have been labeled as obligate asexual species. It is becoming increasingly clear, however, that cryptic sexual programs may e...
- I kappa B kinase epsilon (IKK epsilon) regulates the balance between type I and type II interferon responses
[作者:Ng, SL; Friedman, BA; Schmid, S; Gertz, J; Myers, RM; tenOever, BR; Maniatis, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21170-21175 , 文章类型: Article,,卷期:2011年108-52]
- Virus infection induces the production of type I and type II interferons (IFN-I and IFN-II), cytokines that mediate the antiviral response. IFN-I (IFN-alpha and IFN-beta) induces the assembly of IFN-stimulated gene facto...
- Structural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction
[作者:Simpson, AA; Mohammed, F; Salim, M; Tranter, A; Rickinson, AB; Stauss, HJ; Moss, PAH; Steven, NM; Willcox, BE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21176-21181 , 文章类型: Article,,卷期:2011年108-52]
- Immunotherapies targeting peptides presented by allogeneic MHC molecules offer the prospect of circumventing tolerance to key tumor-associated self-antigens. However, the degree of antigen specificity mediated by allorea...
- Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection
[作者:Aubert, RD; Kamphorst, AO; Sarkar, S; Vezys, V; Ha, SJ; Barber, DL; Ye, LL; Sharpe, AH; Freeman, GJ; Ahmed, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21182-21187 , 文章类型: Article,,卷期:2011年108-52]
- CD4 T cells play a critical role in regulating CD8 T-cell responses during chronic viral infection. Several studies in animal models and humans have shown that the absence of CD4 T-cell help results in severe dysfunction...
- Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
[作者:Wu, J; Jiao, YC; Dal Molin, M; Maitra, A; de Wilde, RF; Wood, LD; Eshleman, JR; Goggins, MG; Wolfgang, CL; Canto, MI; Schulick, RD; Edil, BH; Choti, MA; Adsay, V; Klimstra, DS; Offerhaus, GJA; Klein, AP; Kopelovich, L; Carter, H; Karchin, R; Allen, PJ; Schmidt, CM; Naito, Y; Diaz, LA; Kinzler, KW; Papadopoulos, N; Hruban, RH; Vogelstein, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21188-21193 , 文章类型: Article,,卷期:2011年108-52]
- More than 2% of adults harbor a pancreatic cyst, a subset of which progresses to invasive lesions with lethal consequences. To assess the genomic landscapes of neoplastic cysts of the pancreas, we determined the exomic s...
- High-throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment
[作者:Logan, AC; Gao, H; Wang, CL; Sahaf, B; Jones, CD; Marshall, EL; Buno, I; Armstrong, R; Fire, AZ; Weinberg, KI; Mindrinos, M; Zehnder, JL; Boyd, SD; Xiao, WZ; Davis, RW; Miklos, DB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21194-21199 , 文章类型: Article,,卷期:2011年108-52]
- The primary cause of poor outcome following allogeneic hematopoietic cell transplantation (HCT) for chronic lymphocytic leukemia (CLL) is disease recurrence. Detection of increasing minimal residual disease (MRD) followi...
- Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease
[作者:Lu, J; Yang, CZ; Chen, M; Ye, DY; Lonser, RR; Brady, RO; Zhuang, ZP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21200-21205 , 文章类型: Article,,卷期:2011年108-52]
- Gaucher disease (GD) is caused by a spectrum of genetic mutations within the gene encoding the lysosomal enzyme glucocerebrosidase (GCase). These mutations often lead to misfolded proteins that are recognized by the unfo...
- Niche specialization of terrestrial archaeal ammonia oxidizers
[作者:Gubry-Rangin, C; Hai, B; Quince, C; Engel, M; Thomson, BC; James, P; Schloter, M; Griffiths, RI; Prosser, JI; Nicol, GW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21206-21211 , 文章类型: Article,,卷期:2011年108-52]
- Soil pH is a major determinant of microbial ecosystem processes and potentially a major driver of evolution, adaptation, and diversity of ammonia oxidizers, which control soil nitrification. Archaea are major components ...
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