- Large area and structured epitaxial graphene produced by confinement controlled sublimation of silicon carbide
[作者:de Heer, WA; Berger, C; Ruan, M; Sprinkle, M; Li, XB; Hu, YK; Zhang, BQ; Hankinson, J; Conrad, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16900-16905 , 文章类型: Article,,卷期:2011年108-41]
- After the pioneering investigations into graphene-based electronics at Georgia Tech, great strides have been made developing epitaxial graphene on silicon carbide (EG) as a new electronic material. EG has not only demons...
- Protein delivery using engineered virus-like particles
[作者:Kaczmarczyk, SJ; Sitaraman, K; Young, HA; Hughes, SH; Chatterjee, DK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16998-17003 , 文章类型: Article,,卷期:2011年108-41]
- Over the years, researchers have developed several methods to deliver macromolecules into the cytosol and nucleus of living cells. However, there are limitations to all of these methods. The problems include (i) ineffici...
- Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway
[作者:Tofaris, GK; Kim, HT; Hourez, R; Jung, JW; Kim, KP; Goldberg, AL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17004-17009 , 文章类型: Article,,卷期:2011年108-41]
- alpha-Synuclein is an abundant brain protein that binds to lipid membranes and is involved in the recycling of presynaptic vesicles. In Parkinson disease, alpha-synuclein accumulates in intraneuronal inclusions often con...
- Double-core-hole spectroscopy for chemical analysis with an intense X-ray femtosecond laser
[作者:Berrah, N; Fang, L; Murphy, B; Osipov, T; Ueda, K; Kukk, E; Feifel, R; van der Meulen, P; Salen, P; Schmidt, HT; Thomas, RD; Larsson, M; Richter, R; Prince, KC; Bozek, JD; Bostedt, C; Wada, S; Piancastelli, MN; Tashiro, M; Ehara, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16912-16915 , 文章类型: Article,,卷期:2011年108-41]
- Theory predicts that double-core-hole (DCH) spectroscopy can provide a new powerful means of differentiating between similar chemical systems with a sensitivity not hitherto possible. Although DCH ionization on a single ...
- Disruption of insect diapause using agonists and an antagonist of diapause hormone
[作者:Zhang, QR; Nachman, RJ; Kaczmarek, K; Zabrocki, J; Denlinger, DL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16922-16926 , 文章类型: Article,,卷期:2011年108-41]
- The dormant state known as diapause is widely exploited by insects to circumvent winter and other adverse seasons. For an insect to survive, feed, and reproduce at the appropriate time of year requires fine coordination ...
- Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation
[作者:Benod, C; Vinogradova, MV; Jouravel, N; Kim, GE; Fletterick, RJ; Sablin, EP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16927-16931 , 文章类型: Article,,卷期:2011年108-41]
- An essential regulator of gene transcription, nuclear receptor liver receptor homologue 1 (LRH-1) controls cell differentiation in the developing pancreas and maintains cholesterol homeostasis in adults. Recent genome-wi...
- CCAAT/enhancer binding protein alpha (C/EBP alpha)-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation
[作者:Di Tullio, A; Thien, PVM; Schubert, A; Mansson, R; Graf, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17016-17021 , 文章类型: Article,,卷期:2011年108-41]
- Earlier work has shown that pre-B cells can be converted into macrophages by the transcription factor CCAAT/enhancer binding protein a at very high frequencies. Using this system, we performed a systematic analysis of wh...
- Modulation of canonical Wnt signaling by the extracellular matrix component biglycan
[作者:Berendsen, AD; Fisher, LW; Kilts, TM; Owens, RT; Robey, PG; Gutkind, JS; Young, MF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17022-17027 , 文章类型: Article,,卷期:2011年108-41]
- Although extracellular control of canonical Wnt signaling is crucial for tissue homeostasis, the role of the extracellular microenvironment in modulating this signaling pathway is largely unknown. In the present study, w...
- TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus
[作者:Zheng, K; An, JJ; Yang, F; Xu, WF; Xu, ZQD; Wu, JY; Hokfelt, TGM; Fisahn, A; Xu, BJ; Lu, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17201-17206 , 文章类型: Article,,卷期:2011年108-41]
- Although brain-derived neurotrophic factor (BDNF) is known to regulate circuit development and synaptic plasticity, its exact role in neuronal network activity remains elusive. Using mutant mice (TrkB-PV(-/-)) in which t...
- Inhibition recruitment in prefrontal cortex during sleep spindles and gating of hippocampal inputs
[作者:Peyrache, A; Battaglia, FP; Destexhe, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17207-17212 , 文章类型: Article,,卷期:2011年108-41]
- During light slow-wave sleep, the thalamo-cortical network oscillates in waxing-and-waning patterns at about 7 to 14 Hz and lasting for 500 ms to 3 s, called spindles, with the thalamus rhythmically sending strong excita...
- Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition
[作者:Schmidt, MV; Schulke, JP; Liebl, C; Stiess, M; Avrabos, C; Bock, J; Wochnik, GM; Davies, HA; Zimmermann, N; Scharf, SH; Trumbach, D; Wurst, W; Zieglgansberger, W; Turck, C; Holsboer, F; Stewart, MG; Bradke, F; Eder, M; Muller, MB; Rein, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17213-17218 , 文章类型: Article,,卷期:2011年108-41]
- Stress has been identified as a major causal factor for many mental disorders. However, our knowledge about the chain of molecular and cellular events translating stress experience into altered behavior is still rather s...
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