- Synergic reprogramming of mammalian cells by combined exposure to mitotic Xenopus egg extracts and transcription factors
[作者:Ganier, O; Bocquet, S; Peiffer, I; Brochard, V; Arnaud, P; Puy, A; Jouneau, A; Feil, R; Renard, JP; Mechali, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17331-17336 , 文章类型: Article,,卷期:2011年108-42]
- Transfer of somatic cell nuclei to enucleated eggs and ectopic expression of specific transcription factors are two different reprogramming strategies used to generate pluripotent cells from differentiated cells. However...
- Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere- associated protein CENP-F to kinetochores
[作者:Serio, G; Margaria, V; Jensen, S; Oldani, A; Bartek, J; Bussolino, F; Lanzetti, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17337-17342 , 文章类型: Article,,卷期:2011年108-42]
- Rab5 is a small GTPase known to regulate vesicular trafficking during interphase. Here, we show that Rab5 also plays an unexpected role during mitotic progression. RNAi-mediated silencing of Rab5 caused defects in chromo...
- Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis
[作者:Capalbo, L; D'Avino, PP; Archambault, V; Glover, DM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17343-17348 , 文章类型: Article,,卷期:2011年108-42]
- The small GTPase Rab5 is a conserved regulator of membrane trafficking; it regulates the formation of early endosomes, their transport along microtubules, and the fusion to the target organelles. Although several members...
- Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure
[作者:Geh, E; Meng, QH; Mongan, M; Wang, JC; Takatori, A; Zheng, Y; Puga, A; Lang, RA; Xia, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17349-17354 , 文章类型: Article,,卷期:2011年108-42]
- Developmental eyelid closure is an evolutionarily conserved morphogenetic event requiring proliferation, differentiation, cytoskeleton reorganization, and migration of epithelial cells at the tip of the developing eyelid...
- Continuous dental replacement in a hyper-chisel tooth digging rodent
[作者:Rodrigues, HG; Marangoni, P; Sumbera, R; Tafforeau, P; Wendelen, W; Viriot, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17355-17359 , 文章类型: Article,,卷期:2011年108-42]
- Contrary to their reptilian ancestors, which had numerous dental generations, mammals are known to usually develop only two generations of teeth. However, a few mammal species have acquired the ability to continuously re...
- Hydroxyurea induces de novo copy number variants in human cells
[作者:Arlt, MF; Ozdemir, AC; Birkeland, SR; Wilson, TE; Glover, TW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17360-17365 , 文章类型: Article,,卷期:2011年108-42]
- Copy number variants (CNVs) are widely distributed throughout the human genome, where they contribute to genetic variation and phenotypic diversity. Spontaneous CNVs are also a major cause of genetic and developmental di...
- Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage
[作者:Shi, J; Knevel, R; Suwannalai, P; van der Linden, MP; Janssen, GMC; van Veelen, PA; Levarht, NEW; van der Helm-van Mil, AHM; Cerami, A; Huizinga, TWJ; Toes, REM; Trouw, LA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17372-17377 , 文章类型: Article,,卷期:2011年108-42]
- Autoimmune responses against posttranslationally modified antigens are a hallmark of several autoimmune diseases. For example, antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the p...
- Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model
[作者:Limmer, S; Haller, S; Drenkard, E; Lee, J; Yu, S; Kocks, C; Ausubel, FM; Ferrandon, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17378-17383 , 文章类型: Article,,卷期:2011年108-42]
- An in-depth mechanistic understanding of microbial infection necessitates a molecular dissection of host-pathogen relationships. Both Drosophila melanogaster and Pseudomonas aeruginosa have been intensively studied. Here...
- Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells
[作者:Chiesa, S; Morbelli, S; Morando, S; Massollo, M; Marini, C; Bertoni, A; Frassoni, F; Bartolome, ST; Sambuceti, G; Traggiai, E; Uccelli, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17384-17389 , 文章类型: Article,,卷期:2011年108-42]
- Dendritic cells (DC) are highly specialized antigen-presenting cells characterized by the ability to prime T-cell responses. Mesenchymal stem cells (MSC) are adult stromal progenitor cells displaying immunomodulatory act...
- Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis
[作者:Li, XD; Chiu, YH; Ismail, AS; Behrendt, CL; Wight-Carter, M; Hooper, LV; Chen, ZJJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17390-17395 , 文章类型: Article,,卷期:2011年108-42]
- RIG-I-like receptors (RLRs) activate host innate immune responses against virus infection through recruiting the mitochondrial adaptor protein MAVS (also known as IPS1, VISA, or CARDIF). Here we show that MAVS also plays...
- Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
[作者:Martinez, J; Almendinger, J; Oberst, A; Ness, R; Dillon, CP; Fitzgerald, P; Hengartner, MO; Green, DR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17396-17401 , 文章类型: Article,,卷期:2011年108-42]
- The recognition and clearance of dead cells is a process that must occur efficiently to prevent an autoimmune or inflammatory response. Recently, a process was identified wherein the autophagy machinery is recruited to p...
- Whole-genome nucleotide diversity, recombination, and linkage disequilibrium in the model legume Medicago truncatula
[作者:Branca, A; Paape, TD; Zhou, P; Briskine, R; Farmer, AD; Mudge, J; Bharti, AK; Woodward, JE; May, GD; Gentzbittel, L; Ben, C; Denny, R; Sadowsky, MJ; Ronfort, J; Bataillon, T; Young, ND; Tiffin, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E864-E870 , 文章类型: Article,,卷期:2011年108-42]
- Medicago truncatula is a model for investigating legume genetics, including the genetics and evolution of legume-rhizobia symbiosis. We used whole-genome sequence data to identify and characterize sequence polymorphisms ...
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