- A role for c-Myc in regulating anti-mycobacterial responses
[作者:Yim, HCH; Li, JCB; Pong, JCH; Lau, ASY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17749-17754 , 文章类型: Article,,卷期:2011年108-43]
- c-Myc (Myc) is a well known transcription factor that regulates many essential cellular processes; however, its role in modulating immunity is not known. Here, we showed different species of mycobacteria can induce Myc e...
- Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids
[作者:Garcia-Alles, LF; Collmann, A; Versluis, C; Lindner, B; Guiard, J; Maveyraud, L; Huc, E; Im, JS; Sansano, S; Brando, T; Julien, S; Prandi, J; Gilleron, M; Porcelli, SA; de la Salle, H; Heck, AJR; Mori, L; Puzo, G; Mourey, L; De Libero, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17755-17760 , 文章类型: Article,,卷期:2011年108-43]
- The mechanisms permitting nonpolymorphic CD1 molecules to present lipid antigens that differ considerably in polar head and aliphatic tails remain elusive. It is also unclear why hydrophobic motifs in the aliphatic tails...
- Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
[作者:Wang, NJ; Sanborn, Z; Arnett, KL; Bayston, LJ; Liao, W; Proby, CM; Leigh, IM; Collisson, EA; Gordon, PB; Jakkula, L; Pennypacker, S; Zou, Y; Sharma, M; North, JP; Vemula, SS; Mauro, TM; Neuhaus, IM; LeBoit, PE; Hur, JS; Park, K; Huh, N; Kwok, PY; Arron, ST; Massion, PP; Bale, AE; Haussler, D; Cleaver, JE; Gray, JW; Spellman, PT; South, AP; Aster, JC; Blacklow, SC; Cho, RJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17761-17766 , 文章类型: Article,,卷期:2011年108-43]
- Squamous cell carcinomas (SCCs) are one of the most frequent forms of human malignancy, but, other than TP53 mutations, few causative somatic aberrations have been identified. We identified NOTCH1 or NOTCH2 mutations in ...
- Sympathetic control of bone mass regulated by osteopontin
[作者:Nagao, M; Feinstein, TN; Ezura, Y; Hayata, T; Notomi, T; Saita, Y; Hanyu, R; Hemmi, H; Izu, Y; Takeda, S; Wang, K; Rittling, S; Nakamoto, T; Kaneko, K; Kurosawa, H; Karsenty, G; Denhardt, DT; Vilardaga, JP; Noda, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17767-17772 , 文章类型: Article,,卷期:2011年108-43]
- The sympathetic nervous system suppresses bone mass by mechanisms that remain incompletely elucidated. Using cell-based and murine genetics approaches, we show that this activity of the sympathetic nervous systemrequires...
- Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
[作者:Konishi, H; Mohseni, M; Tamaki, A; Garay, JP; Croessmann, S; Karnan, S; Ota, A; Wong, HY; Konishi, Y; Karakas, B; Tahir, K; Abukhdeir, AM; Gustin, JP; Cidado, J; Wang, GM; Cosgrove, D; Cochran, R; Jelovac, D; Higgins, MJ; Arena, S; Hawkins, L; Lauring, J; Gross, AL; Heaphy, CM; Hosokawa, Y; Gabrielson, E; Meeker, AK; Visvanathan, K; Argani, P; Bachman, KE; Park, BH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17773-17778 , 文章类型: Article,,卷期:2011年108-43]
- Biallelic inactivation of cancer susceptibility gene BRCA1 leads to breast and ovarian carcinogenesis. Paradoxically, BRCA1 deficiency in mice results in early embryonic lethality, and similarly, lack of BRCA1 in human c...
- Antitumorigenic potential of STAT3 alternative splicing modulation
[作者:Zammarchi, F; de Stanchina, E; Bournazou, E; Supakorndej, T; Martires, K; Riedel, E; Corben, AD; Bromberg, JF; Cartegni, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17779-17784 , 文章类型: Article,,卷期:2011年108-43]
- Signal transducer and activator of transcription 3 (STAT3) plays a central role in the activation of multiple oncogenic pathways. Splicing variant STAT3 beta uses an alternative acceptor site within exon 23 that leads to...
- Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus
[作者:Andersen, JM; Barrangou, R; Abou Hachem, M; Lahtinen, S; Goh, YJ; Svensson, B; Klaenhammer, TR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17785-17790 , 文章类型: Article,,卷期:2011年108-43]
- Probiotic microbes rely on their ability to survive in the gastrointestinal tract, adhere to mucosal surfaces, and metabolize available energy sources from dietary compounds, including prebiotics. Genome sequencing proje...
- Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase
[作者:Chen, Y; Patel, NA; Crombie, A; Scrivens, JH; Murrell, JC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17791-17796 , 文章类型: Article,,卷期:2011年108-43]
- Flavin-containing monooxygenases (FMOs) are one of the most important monooxygenase systems in Eukaryotes and have many important physiological functions. FMOs have also been found in bacteria; however, their physiologic...
- A soluble alpha-synuclein construct forms a dynamic tetramer
[作者:Wang, W; Perovic, I; Chittuluru, J; Kaganovich, A; Nguyen, LTT; Liao, JL; Auclair, JR; Johnson, D; Landeru, A; Simorellis, AK; Ju, SL; Cookson, MR; Asturias, FJ; Agar, JN; Webb, BN; Kang, CH; Ringe, D; Petsko, GA; Pochapsky, TC; Hoang, QQ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17797-17802 , 文章类型: Article,,卷期:2011年108-43]
- A heterologously expressed form of the human Parkinson disease-associated protein alpha-synuclein with a 10-residue N-terminal extension is shown to form a stable tetramer in the absence of lipid bilayers or micelles. Se...
- Astrocytes carrying the superoxide dismutase 1 (SOD1(G93A)) mutation induce wild-type motor neuron degeneration in vivo
[作者:Papadeas, ST; Kraig, SE; O'Banion, C; Lepore, AC; Maragakis, NJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17803-17808 , 文章类型: Article,,卷期:2011年108-43]
- Recent studies highlight astrocytes as key drivers of motor neuron (MN) degeneration and disease propagation in mutant human superoxide dismutase 1 (mSOD1)-mediated amyotrophic lateral sclerosis. However, in vivo analysi...
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