- Transgenerational Epigenetic Instability Is a Source of Novel Methylation Variants
[作者：Schmitz, RJ; Schultz, MD; Lewsey, MG; O'Malley, RC; Urich, MA; Libiger, O; Schork, NJ; Ecker, JR,期刊：Science, 页码：369-373 , 文章类型： Article，,卷期：2011年334-6054]
- Epigenetic information, which may affect an organism's phenotype, can be stored and stably inherited in the form of cytosine DNA methylation. Changes in DNA methylation can produce meiotically stable epialleles that affe...
- Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
[作者：Azoitei, ML; Correia, BE; Ban, YEA; Carrico, C; Kalyuzhniy, O; Chen, L; Schroeter, A; Huang, PS; McLellan, JS; Kwong, PD; Baker, D; Strong, RK; Schief, WR,期刊：Science, 页码：373-376 , 文章类型： Article，,卷期：2011年334-6054]
- The manipulation of protein backbone structure to control interaction and function is a challenge for protein engineering. We integrated computational design with experimental selection for grafting the backbone and side...
- Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination
[作者：Dueber, EC; Schoeffler, AJ; Lingel, A; Elliott, JM; Fedorova, AV; Giannetti, AM; Zobel, K; Maurer, B; Varfolomeev, E; Wu, P; Wallweber, HJA; Hymowitz, SG; Deshayes, K; Vucic, D; Fairbrother, WJ,期刊：Science, 页码：376-380 , 文章类型： Article，,卷期：2011年334-6054]
- Inhibitor of apoptosis (IAP) proteins are negative regulators of cell death. IAP family members contain RING domains that impart E3 ubiquitin ligase activity. Binding of endogenous or small-molecule antagonists to select...
- Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding
[作者：Zhou, M; Morgner, N; Barrera, NP; Politis, A; Isaacson, SC; Matak-Vinkovic, D; Murata, T; Bernal, RA; Stock, D; Robinson, CV,期刊：Science, 页码：380-385 , 文章类型： Article，,卷期：2011年334-6054]
- The ability of electrospray to propel large viruses into a mass spectrometer is established and is rationalized by analogy to the atmospheric transmission of the common cold. Much less clear is the fate of membrane-embed...
- Cerebellum Shapes Hippocampal Spatial Code
[作者：Rochefort, C; Arabo, A; Andre, M; Poucet, B; Save, E; Rondi-Reig, L,期刊：Science, 页码：385-389 , 文章类型： Article，,卷期：2011年334-6054]
- Spatial representation is an active process that requires complex multimodal integration from a large interacting network of cortical and subcortical structures. We sought to determine the role of cerebellar protein kina...
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