- Caspase-mediated Cleavage of RNA-binding Protein HuR Regulates c-Myc Protein Expression after Hypoxic Stress
[作者:Talwar, S; Jin, JF; Carroll, B; Liu, AG; Gillespie, MB; Palanisamy, V,期刊:Journal of Biological Chemistry, 页码:32333-32343 , 文章类型: Article,,卷期:2011年286-37]
- Altered expression of RNA-binding proteins modulates gene expression in association with mRNAs encoding many proto-oncogenes, cytokines, chemokines, and proinflammatory factors. Huantigen R (HuR), a ubiquitously expresse...
- Cullin 4B Protein Ubiquitin Ligase Targets Peroxiredoxin III for Degradation
[作者:Li, X; Lu, DF; He, FJ; Zhou, HB; Liu, Q; Wang, Y; Shao, CS; Gong, YQ,期刊:Journal of Biological Chemistry, 页码:32344-32354 , 文章类型: Article,,卷期:2011年286-37]
- Cullin 4B (CUL4B) is a scaffold protein that assembles cullin-RING ubiquitin ligase (E3) complexes. Recent studies have revealed that germ-line mutations in CUL4B can cause mental retardation, short stature, and many oth...
- COMMD1 (Copper Metabolism MURR1 Domain-containing Protein 1) Regulates Cullin RING Ligases by Preventing CAND1 (Cullin-associated Nedd8-dissociated Protein 1) Binding
[作者:Mao, XC; Gluck, N; Chen, BZ; Starokadomskyy, P; Li, HY; Maine, GN; Burstein, E,期刊:Journal of Biological Chemistry, 页码:32355-32365 , 文章类型: Article,,卷期:2011年286-37]
- Cullin RING ligases (CRLs), the most prolific class of ubiquitin ligase enzymes, are multimeric complexes that regulate a wide range of cellular processes. CRL activity is regulated by CAND1 (Cullin-associated Nedd8-diss...
- A Novel Intronic cAMP Response Element Modulator (CREM) Promoter Is Regulated by Activator Protein-1 (AP-1) and Accounts for Altered Activation-induced CREM Expression in T Cells from Patients with Systemic Lupus Erythematosus
[作者:Rauen, T; Benedyk, K; Juang, YT; Kerkhoff, C; Kyttaris, VC; Roth, J; Tsokos, GC; Tenbrock, K,期刊:Journal of Biological Chemistry, 页码:32366-32372 , 文章类型: Article,,卷期:2011年286-37]
- The transcriptional repressor cAMP response element modulator (CREM) alpha has important roles in normal T cell physiology and contributes to aberrant T cell function in patients with systemic lupus erythematosus (SLE). ...
- Crystal Structure of Mycobacterium tuberculosis Zinc-dependent Metalloprotease-1 (Zmp1), a Metalloprotease Involved in Pathogenicity
[作者:Ferraris, DM; Sbardella, D; Petrera, A; Marini, S; Amstutz, B; Coletta, M; Sander, P; Rizzi, M,期刊:Journal of Biological Chemistry, 页码:32475-32482 , 文章类型: Article,,卷期:2011年286-37]
- Mycobacterium tuberculosis, the causative agent of tuberculosis, parasitizes host macrophages. The resistance of the tubercle bacilli to the macrophage hostile environment relates to their ability to impair phagosome mat...
- Effects of Simulated Microgravity on Expression Profile of MicroRNA in Human Lymphoblastoid Cells
[作者:Mangala, LS; Zhang, Y; He, ZH; Emami, K; Ramesh, GT; Story, M; Rohde, LH; Wu, HL,期刊:Journal of Biological Chemistry, 页码:32483-32490 , 文章类型: Article,,卷期:2011年286-37]
- This study explores the changes in expression of microRNA (miRNA) and related genes under simulated microgravity conditions. In comparison with static 1 x g, microgravity has been shown to alter global gene expression pa...
- alpha-Phenyl-N-tert-butylnitrone (PBN) Prevents Light-induced Degeneration of the Retina by Inhibiting RPE65 Protein Isomerohydrolase Activity
[作者:Mandal, MNA; Moiseyev, GP; Elliott, MH; Kasus-Jacobi, A; Li, XM; Chen, H; Zheng, LX; Nikolaeva, O; Floyd, RA; Ma, JX; Anderson, RE,期刊:Journal of Biological Chemistry, 页码:32491-32501 , 文章类型: Article,,卷期:2011年286-37]
- alpha-Phenyl-N-tert-butylnitrone (PBN), a free radical spin trap, has been shown previously to protect retinas against light-induced neurodegeneration, but the mechanism of protection is not known. Here we report that PB...
- RB1CC1 Protein Positively Regulates Transforming Growth Factor-beta Signaling through the Modulation of Arkadia E3 Ubiquitin Ligase Activity
[作者:Koinuma, D; Shinozaki, M; Nagano, Y; Ikushima, H; Horiguchi, K; Goto, K; Chano, T; Saitoh, M; Imamura, T; Miyazono, K; Miyazawa, K,期刊:Journal of Biological Chemistry, 页码:32502-32512 , 文章类型: Article,,卷期:2011年286-37]
- Transforming growth factor-beta (TGF-beta) signaling is controlled by a variety of regulators, of which Smad7, c-Ski, and SnoN play a pivotal role in its negative regulation. Arkadia is a RING-type E3 ubiquitin ligase th...
- Functional Expression of the PorAH Channel from Corynebacterium glutamicum in Cell-free Expression Systems IMPLICATIONS FOR THE ROLE OF THE NATURALLY OCCURRING MYCOLIC ACID MODIFICATION
[作者:Rath, P; Demange, P; Saurel, O; Tropis, M; Daffe, M; Dotsch, V; Ghazi, A; Bernhard, F; Milon, A,期刊:Journal of Biological Chemistry, 页码:32525-32532 , 文章类型: Article,,卷期:2011年286-37]
- PorA and PorH are two small membrane proteins from the outer membrane of Corynebacterium glutamicum, which have been shown to form heteromeric ion channels and to be post-translationally modified by mycolic acids. Any st...
- Uncoupling Protein 3 (UCP3) Modulates the Activity of Sarco/Endoplasmic Reticulum Ca(2+)-ATPase (SERCA) by Decreasing Mitochondrial ATP Production
[作者:De Marchi, U; Castelbou, C; Demaurex, N,期刊:Journal of Biological Chemistry, 页码:32533-32541 , 文章类型: Article,,卷期:2011年286-37]
- The uncoupling proteins UCP2 and UCP3 have been postulated to catalyze Ca(2+) entry across the inner membrane of mitochondria, but this proposal is disputed, and other, unrelated proteins have since been identified as th...
- Deletion of the Mint3/Apba3 Gene in Mice Abrogates Macrophage Functions and Increases Resistance to Lipopolysaccharide-induced Septic Shock
[作者:Hara, T; Mimura, K; Abe, T; Shioi, G; Seiki, M; Sakamoto, T,期刊:Journal of Biological Chemistry, 页码:32542-32551 , 文章类型: Article,,卷期:2011年286-37]
- Two major metabolic systems are usually used to generate ATP: oxidative phosphorylation (OXPHOS) in the mitochondria and glycolysis. Most types of cells employ OXPHOS for ATP production during normoxia but then shift ene...
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