- Increased Expression of the Pro-apoptotic Protein BIM, a Mechanism for cAMP/Protein Kinase A (PKA)-induced Apoptosis of Immature T Cells
[作者:Zambon, AC; Wilderman, A; Ho, A; Insel, PA,期刊:Journal of Biological Chemistry, 页码:33260-33267 , 文章类型: Article,,卷期:2011年286-38]
- The second messenger cAMP is proapoptotic for numerous cell types, but the mechanism for this proapoptotic action is not defined. Here, we use murine CD4(+)/CD8(+) S49 lymphoma cells and isolated thymocytes to assess thi...
- Interleukin-1 Activates Synthesis of Interleukin-6 by Interfering with a KH-type Splicing Regulatory Protein (KSRP)-dependent Translational Silencing Mechanism
[作者:Dhamija, S; Kuehne, N; Winzen, R; Doerrie, A; Dittrich-Breiholz, O; Thakur, BK; Kracht, M; Holtmann, H,期刊:Journal of Biological Chemistry, 页码:33279-33288 , 文章类型: Article,,卷期:2011年286-38]
- Post-transcriptional mechanisms play an important role in the control of inflammatory gene expression. The heterogeneous nuclear ribonucleoprotein K homology (KH)-type splicing regulatory protein (KSRP) triggers rapid de...
- Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle
[作者:Sun, Z; Singh, N; Mullican, SE; Everett, LJ; Li, L; Yuan, LJ; Liu, X; Epstein, JA; Lazar, MA,期刊:Journal of Biological Chemistry, 页码:33301-33309 , 文章类型: Article,,卷期:2011年286-38]
- Many human diseases result from the influence of the nutritional environment on gene expression. The environment interacts with the genome by altering the epigenome, including covalent modification of nucleosomal histone...
- Neuron-targeted Caveolin-1 Protein Enhances Signaling and Promotes Arborization of Primary Neurons
[作者:Head, BP; Hu, Y; Finley, JC; Saldana, MD; Bonds, JA; Miyanohara, A; Niesman, IR; Ali, SS; Murray, F; Insel, PA; Roth, DM; Patel, HH; Patel, PM,期刊:Journal of Biological Chemistry, 页码:33310-33321 , 文章类型: Article,,卷期:2011年286-38]
- Decreased expression of prosurvival and progrowth-stimulatory pathways, in addition to an environment that inhibits neuronal growth, contribute to the limited regenerative capacity in the central nervous system following...
- Genome-wide in Silico Identification of New Conserved and Functional Retinoic Acid Receptor Response Elements (Direct Repeats Separated by 5 bp)
[作者:Lalevee, S; Anno, YN; Chatagnon, A; Samarut, E; Poch, O; Laudet, V; Benoit, G; Lecompte, O; Rochette-Egly, C,期刊:Journal of Biological Chemistry, 页码:33322-33334 , 文章类型: Article,,卷期:2011年286-38]
- The nuclear retinoic acid receptors interact with specific retinoic acid (RA) response elements (RAREs) located in the promoters of target genes to orchestrate transcriptional networks involved in cell growth and differe...
- Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase C delta, and p38 Mitogen-activated Protein Kinase (MAPK)
[作者:Thorp, E; Vaisar, T; Subramanian, M; Mautner, L; Blobel, C; Tabas, I,期刊:Journal of Biological Chemistry, 页码:33335-33344 , 文章类型: Article,,卷期:2011年286-38]
- Mer tyrosine kinase (MerTK) is an integral membrane protein that is preferentially expressed by phagocytic cells, where it promotes efferocytosis and inhibits inflammatory signaling. Proteolytic cleavage of MerTK at an u...
- Zebrafish mll Gene Is Essential for Hematopoiesis
[作者:Wan, XY; Hu, B; Liu, JX; Feng, X; Xiao, WH,期刊:Journal of Biological Chemistry, 页码:33345-33357 , 文章类型: Article,,卷期:2011年286-38]
- Studies implicate an important role for the mixed lineage leukemia (Mll) gene in hematopoiesis, mainly through maintaining Hox gene expression. However, the mechanisms underlying Mll-mediated hematopoiesis during embryog...
- Systematic Identification of Tubulin-interacting Fragments of the Microtubule-associated Protein Tau Leads to a Highly Efficient Promoter of Microtubule Assembly
[作者:Fauquant, C; Redeker, V; Landrieu, I; Wieruszeski, JM; Verdegem, D; Laprevote, O; Lippens, G; Gigant, B; Knossow, M,期刊:Journal of Biological Chemistry, 页码:33358-33368 , 文章类型: Article,,卷期:2011年286-38]
- Tau is a microtubule-associated protein that stabilizes microtubules and stimulates their assembly. Current descriptions of the tubulin-interacting regions of Tau involve microtubules as the target and result mainly from...
- Tripartite Motif 24 (Trim24/Tif1 alpha) Tumor Suppressor Protein Is a Novel Negative Regulator of Interferon (IFN)/Signal Transducers and Activators of Transcription (STAT) Signaling Pathway Acting through Retinoic Acid Receptor alpha (Rar alpha) Inhibition
[作者:Tisserand, J; Khetchoumian, K; Thibault, C; Dembele, D; Chambon, P; Losson, R,期刊:Journal of Biological Chemistry, 页码:33369-33379 , 文章类型: Article,,卷期:2011年286-38]
- Recent genetic studies in mice have established that the nuclear receptor coregulator Trim24/Tif1 alpha suppresses hepatocarcinogenesis by inhibiting retinoic acid receptor alpha (Rara)-dependent transcription and cell p...
- Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T alpha-Synuclein IMPLICATIONS FOR NEURONAL CELL DEATH IN PARKINSON DISEASE
[作者:Chew, KCM; Ang, ET; Tai, YK; Tsang, F; Lo, SQ; Ong, E; Ong, WY; Shen, HM; Lim, KL; Dawson, VL; Dawson, TM; Soong, TW,期刊:Journal of Biological Chemistry, 页码:33380-33389 , 文章类型: Article,,卷期:2011年286-38]
- Parkinson disease (PD), a prevalent neurodegenerative motor disorder, is characterized by the rather selective loss of dopaminergic neurons and the presence of alpha-synuclein-enriched Lewy body inclusions in the substan...
- Spatiotemporally Distinct Protein Kinase D Activation in Adult Cardiomyocytes in Response to Phenylephrine and Endothelin
[作者:Bossuyt, J; Chang, CW; Helmstadter, K; Kunkel, MT; Newton, AC; Campbell, KS; Martin, JL; Bossuyt, S; Robia, SL; Bers, DM,期刊:Journal of Biological Chemistry, 页码:33390-33400 , 文章类型: Article,,卷期:2011年286-38]
- Protein kinase D (PKD) is a nodal point in cardiac hypertrophic signaling. It triggers nuclear export of class II histone deacetylase (HDAC) and regulates transcription. Although this pathway is thought to be critical in...
- CEP70 Protein Interacts with gamma-Tubulin to Localize at the Centrosome and Is Critical for Mitotic Spindle Assembly
[作者:Shi, XJ; Sun, XO; Liu, M; Li, DW; Aneja, R; Zhou, J,期刊:Journal of Biological Chemistry, 页码:33401-33408 , 文章类型: Article,,卷期:2011年286-38]
- Deregulation of the mitotic spindle has been implicated in genomic instability, an important aspect of tumorigenesis and malignant transformation. To ensure the fidelity of chromosome transmission, the mitotic spindle is...
- Allosteric Model of Maraviroc Binding to CC Chemokine Receptor 5 (CCR5)
[作者:Garcia-Perez, J; Rueda, P; Alcami, J; Rognan, D; Arenzana-Seisdedos, F; Lagane, B; Kellenberger, E,期刊:Journal of Biological Chemistry, 页码:33409-33421 , 文章类型: Article,,卷期:2011年286-38]
- Maraviroc is a nonpeptidic small molecule human immunodeficiency virus type 1 (HIV-1) entry inhibitor that has just entered the therapeutic arsenal for the treatment of patients. We recently demonstrated that maraviroc b...
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