- Liver-specific Inducible Nitric-oxide Synthase Expression Is Sufficient to Cause Hepatic Insulin Resistance and Mild Hyperglycemia in Mice
[作者:Shinozaki, S; Choi, CS; Shimizu, N; Yamada, M; Kim, M; Zhang, T; Dong, HH; Kim, YB; Kaneki, M,期刊:Journal of Biological Chemistry, 页码:34959-34975 , 文章类型: Article,,卷期:2011年286-40]
- Inducible nitric-oxide synthase (iNOS), a major mediator of inflammation, plays an important role in obesity-induced insulin resistance. Inhibition of iNOS by gene disruption or pharmacological inhibitors reverses or ame...
- Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF
[作者:Bielnicki, JA; Shkumatov, AV; Derewenda, U; Somlyo, AV; Svergun, DI; Derewenda, ZS,期刊:Journal of Biological Chemistry, 页码:35163-35175 , 文章类型: Article,,卷期:2011年286-40]
- PDZRhoGEF (PRG) belongs to a small family of RhoA-specific nucleotide exchange factors that mediates signaling through select G-protein-coupled receptors via G alpha(12/13) and activates RhoA by catalyzing the exchange o...
- Interaction Studies between the Chloroplast Signal Recognition Particle Subunit cpSRP43 and the Full-length Translocase Alb3 Reveal a Membrane-embedded Binding Region in Alb3 Protein
[作者:Dunschede, B; Bals, T; Funke, S; Schunemann, D,期刊:Journal of Biological Chemistry, 页码:35187-35195 , 文章类型: Article,,卷期:2011年286-40]
- Posttranslational targeting of the light-harvesting chlorophyll a, b-binding proteins depends on the function of the chloroplast signal recognition particle, its receptor cpFtsY, and the translocase Alb3. The thylakoid m...
- Deregulation of microRNAs by HIV-1 Vpr Protein Leads to the Development of Neurocognitive Disorders
[作者:Mukerjee, R; Chang, JR; Del Valle, L; Bagashev, A; Gayed, MM; Lyde, RB; Hawkins, BJ; Brailoiu, E; Cohen, E; Power, C; Azizi, SA; Gelman, BB; Sawaya, BE,期刊:Journal of Biological Chemistry, 页码:34976-34985 , 文章类型: Article,,卷期:2011年286-40]
- Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neu...
- Type IX Collagen Interacts with Fibronectin Providing an Important Molecular Bridge in Articular Cartilage
[作者:Parsons, P; Gilbert, SJ; Vaughan-Thomas, A; Sorrell, DA; Notman, R; Bishop, M; Hayes, AJ; Mason, DJ; Duance, VC,期刊:Journal of Biological Chemistry, 页码:34986-34997 , 文章类型: Article,,卷期:2011年286-40]
- Type IX collagen is covalently bound to the surface of type II collagen fibrils within the cartilage extracellular matrix. The N-terminal, globular noncollagenous domain (NC4) of the alpha 1(IX) chain protrudes away from...
- Human Frame Shift Mutations Affecting the Carboxyl Terminus of Perilipin Increase Lipolysis by Failing to Sequester the Adipose Triglyceride Lipase (ATGL) Coactivator AB-hydrolase-containing 5 (ABHD5)
[作者:Gandotra, S; Lim, K; Girousse, A; Saudek, V; O'Rahilly, S; Savage, DB,期刊:Journal of Biological Chemistry, 页码:34998-35006 , 文章类型: Article,,卷期:2011年286-40]
- Perilipin (PLIN1) is a constitutive adipocyte lipid droplet coat protein. N-terminal amphipathic helices and central hydrophobic stretches are thought to anchor it on the lipid droplet, where it appears to function as a ...
- Elucidation of the Molecular Basis of Selective Recognition Uncovers the Interaction Site for the Core Domain of Scorpion alpha-Toxins on Sodium Channels
[作者:Gur, M; Kahn, R; Karbat, I; Regev, N; Wang, JT; Catterall, WA; Gordon, D; Gurevitz, M,期刊:Journal of Biological Chemistry, 页码:35209-35217 , 文章类型: Article,,卷期:2011年286-40]
- Neurotoxin receptor site-3 at voltage-gated Na(+) channels is recognized by various peptide toxin inhibitors of channel inactivation. Despite extensive studies of the effects of these toxins, their mode of interaction wi...
- Muscle Creatine Kinase Deficiency Triggers Both Actin Depolymerization and Desmin Disorganization by Advanced Glycation End Products in Dilated Cardiomyopathy
[作者:Diguet, N; Mallat, Y; Ladouce, R; Clodic, G; Prola, A; Tritsch, E; Blanc, J; Larcher, JC; Delcayre, C; Samuel, JL; Friguet, B; Bolbach, G; Li, ZL; Mericskay, M,期刊:Journal of Biological Chemistry, 页码:35007-35019 , 文章类型: Article,,卷期:2011年286-40]
- Alterations in the balance of cytoskeleton as well as energetic proteins are involved in the cardiac remodeling occurring in dilated cardiomyopathy (DCM). We used two-dimensional DIGE proteomics as a discovery approach t...
- Dynamic Na(+)-H(+) Exchanger Regulatory Factor-1 Association and Dissociation Regulate Parathyroid Hormone Receptor Trafficking at Membrane Microdomains
[作者:Ardura, JA; Wang, B; Watkins, SC; Vilardaga, JP; Friedman, PA,期刊:Journal of Biological Chemistry, 页码:35020-35029 , 文章类型: Article,,卷期:2011年286-40]
- Na/H exchanger regulatory factor-1 (NHERF1) is a cytoplasmic PDZ (postsynaptic density 95/disc large/zona occludens) protein that assembles macromolecular complexes and determines the localization, trafficking, and signa...
- Goodpasture Antigen-binding Protein (GPBP) Directs Myofibril Formation IDENTIFICATION OF INTRACELLULAR DOWNSTREAM EFFECTOR 130-kDa GPBP-INTERACTING PROTEIN (GIP130)
[作者:Revert-Ros, F; Lopez-Pascual, E; Granero-Molto, F; Macias, J; Breyer, R; Zent, R; Hudson, BG; Saadeddin, A; Revert, F; Blasco, R; Navarro, C; Burks, D; Saus, J,期刊:Journal of Biological Chemistry, 页码:35030-35043 , 文章类型: Article,,卷期:2011年286-40]
- Goodpasture antigen-binding protein-1 (GPBP-1) is an exportable non-conventional Ser/Thr kinase that regulates glomerular basement membrane collagen organization. Here we provide evidence that GPBP-1 accumulates in the c...
- Substrate tRNA Recognition Mechanism of a Multisite-specific tRNA Methyltransferase, Aquifex aeolicus Trm1, Based on the X-ray Crystal Structure
[作者:Awai, T; Ochi, A; Ihsanawati; Sengoku, T; Hirata, A; Bessho, Y; Yokoyama, S; Hori, H,期刊:Journal of Biological Chemistry, 页码:35236-35246 , 文章类型: Article,,卷期:2011年286-40]
- Archaeal and eukaryotic tRNA (N(2),N(2)-guanine)-dimethyltransferase (Trm1) produces N(2),N(2)-dimethylguanine at position 26 in tRNA. In contrast, Trm1 from Aquifex aeolicus, a hyper-thermophilic eubacterium, modifies G...
- Functional Importance of Covalent Homodimer of Reelin Protein Linked via Its Central Region
[作者:Yasui, N; Kitago, Y; Beppu, A; Kohno, T; Morishita, S; Gomi, H; Nagae, M; Hattori, M; Takagi, J,期刊:Journal of Biological Chemistry, 页码:35247-35256 , 文章类型: Article,,卷期:2011年286-40]
- Reelin is a 3461-residue secreted glycoprotein that plays a critical role in brain development through its action on target neurons. Although it is known that functional reelin protein exists as multimer formed by interc...
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