- Impact of Self-association on Function of Apolipoprotein A-I
[作者:Jayaraman, S; Abe-Dohmae, S; Yokoyama, S; Cavigiolio, G,期刊:Journal of Biological Chemistry, 页码:35610-35623 , 文章类型: Article,,卷期:2011年286-41]
- Self-association is an inherent property of the lipid-free forms of several exchangeable apolipoproteins, including apolipoprotein A-I (apoA-I), the main protein component of high density lipoproteins (HDL) and an establ...
- Identification of Cystatin SA as a Novel Inhibitor of Acid Ceramidase
[作者:Eliyahu, E; Shtraizent, N; He, XX; Chen, DN; Shalgi, R; Schuchman, EH,期刊:Journal of Biological Chemistry, 页码:35624-35633 , 文章类型: Article,,卷期:2011年286-41]
- Autoproteolytic cleavage of the inactive acid ceramidase (AC) precursor into the active heterodimer exposes a free cysteine residue, leading us to study whether AC could be regulated by one or more members of the cystati...
- Several ADP-ribosylation Factor (Arf) Isoforms Support COPI Vesicle Formation
[作者:Popoff, V; Langer, JD; Reckmann, I; Hellwig, A; Kahn, RA; Brugger, B; Wieland, FT,期刊:Journal of Biological Chemistry, 页码:35634-35642 , 文章类型: Article,,卷期:2011年286-41]
- Newly synthesized proteins and lipids are transported in vesicular carriers along the secretory pathway. Arfs (ADP-ribosylation factors), a family of highly conserved GTPases within the Ras superfamily, control recruitme...
- Group V Phospholipase A(2) in Bone Marrow-derived Myeloid Cells and Bronchial Epithelial Cells Promotes Bacterial Clearance after Escherichia coli Pneumonia
[作者:Degousee, N; Kelvin, DJ; Geisslinger, G; Hwang, DM; Stefanski, E; Wang, XH; Danesh, A; Angioni, C; Schmidt, H; Lindsay, TF; Gelb, MH; Bollinger, J; Payre, C; Lambeau, G; Arm, JP; Keating, A; Rubin, BB,期刊:Journal of Biological Chemistry, 页码:35650-35662 , 文章类型: Article,,卷期:2011年286-41]
- Group V-secreted phospholipase A(2) (GV sPLA(2)) hydrolyzes bacterial phospholipids and initiates eicosanoid biosynthesis. Here, we elucidate the role of GV sPLA(2) in the pathophysiology of Escherichia coli pneumonia. I...
- Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon beta
[作者:Gleason, CE; Ordureau, A; Gourlay, R; Arthur, JSC; Cohen, P,期刊:Journal of Biological Chemistry, 页码:35663-35674 , 文章类型: Article,,卷期:2011年286-41]
- TANK-binding kinase (TBK1) is essential for transcription of the interferon (IFN) beta gene in response to lipopolysaccharide (LPS) and double-stranded RNA, but the molecular mechanisms that underlie the activation of TB...
- Raptor and Rheb Negatively Regulate Skeletal Myogenesis through Suppression of Insulin Receptor Substrate 1 (IRS1)
[作者:Ge, YJ; Yoon, MS; Chen, J,期刊:Journal of Biological Chemistry, 页码:35675-35682 , 文章类型: Article,,卷期:2011年286-41]
- The mammalian target of rapamycin (mTOR) is essential for skeletal myogenesis through controlling distinct cellular pathways. The importance of the canonical mTOR complex 1 signaling components, including raptor, S6K1, a...
- Atomic Resolution X-ray Structure of the Substrate Recognition Domain of Higher Plant Ribulose-bisphosphate Carboxylase/Oxygenase (Rubisco) Activase
[作者:Henderson, JN; Kuriata, AM; Fromme, R; Salvucci, ME; Wachter, RM,期刊:Journal of Biological Chemistry, 页码:35683-35688 , 文章类型: Article,,卷期:2011年286-41]
- The rapid release of tight-binding inhibitors from dead-end ribulose-bisphosphate carboxylase/oxygenase (Rubisco) complexes requires the activity of Rubisco activase, an AAA + ATPase that utilizes chemo-mechanical energy...
- Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein
[作者:Stieren, ES; El Ayadi, A; Xiao, Y; Siller, E; Landsverk, ML; Oberhauser, AF; Barral, JM; Boehning, D,期刊:Journal of Biological Chemistry, 页码:35689-35698 , 文章类型: Article,,卷期:2011年286-41]
- Alzheimer disease (AD) is associated with extracellular deposition of proteolytic fragments of amyloid precursor protein (APP). Although mutations in APP and proteases that mediate its processing are known to result in f...
- Unbinding of Hyaluronan Accelerates the Enzymatic Activity of Bee Hyaluronidase
[作者:Ilias, A; Liliom, K; Greiderer-Kleinlercher, B; Reitinger, S; Lepperdinger, G,期刊:Journal of Biological Chemistry, 页码:35699-35707 , 文章类型: Article,,卷期:2011年286-41]
- Hyaluronan (HA), a polymeric glycosaminoglycan ubiquitously present in higher animals, is hydrolyzed by hyaluronidases (HAases). Here, we used bee HAase as a model enzyme to study the HA-HAase interaction. Located in clo...
- Phosphorylation and Stabilization of Topoisomerase II alpha Protein by p38 gamma Mitogen-activated Protein Kinase Sensitize Breast Cancer Cells to Its Poisons
[作者:Qi, XM; Hou, SW; Lepp, A; Li, RS; Basir, Z; Lou, ZK; Chen, G,期刊:Journal of Biological Chemistry, 页码:35883-35890 , 文章类型: Article,,卷期:2011年286-41]
- Cancer drugs suppress tumor cell growth by inhibiting specific cellular targets. However, most drugs also activate several cellular nonspecific stress pathways, and the implications of these off-target effects are mostly...
- Staphylococcus aureus Protein A Mediates Invasion across Airway Epithelial Cells through Activation of RhoA GTPase Signaling and Proteolytic Activity
[作者:Soong, G; Martin, FJ; Chun, JR; Cohen, TS; Ahn, DS; Prince, A,期刊:Journal of Biological Chemistry, 页码:35891-35898 , 文章类型: Article,,卷期:2011年286-41]
- Background: S. aureus is an important cause of severe pneumonia acquired following upper airway colonization. Results: S. aureus-expressing SpA induces RhoA, EGFR, and calpain activity resulting in disruption of tight ju...
- Structural and Enzymatic Characterization of the Streptococcal ATP/Diadenosine Polyphosphate and Phosphodiester Hydrolase Spr1479/SapH
[作者:Jiang, YL; Zhang, JW; Yu, WL; Cheng, W; Zhang, CC; Frolet, C; Di Guilmi, AM; Vernet, T; Zhou, CZ; Chen, YX,期刊:Journal of Biological Chemistry, 页码:35906-35914 , 文章类型: Article,,卷期:2011年286-41]
- Spr1479 from Streptococcus pneumoniae R6 is a 33-kDa hypothetical protein of unknown function. Here, we determined the crystal structures of its apo-form at 1.90 angstrom and complex forms with inorganic phosphate and AM...
- Regulation of Fertility, Survival, and Cuticle Collagen Function by the Caenorhabditis elegans eaf-1 and ell-1 Genes
[作者:Cai, LQ; Phong, BL; Fisher, AL; Wang, Z,期刊:Journal of Biological Chemistry, 页码:35915-35921 , 文章类型: Article,,卷期:2011年286-41]
- EAF2, an androgen-regulated protein, interacts with members of the ELL (eleven-nineteen lysine-rich leukemia) transcription factor family and also acts as a tumor suppressor. Although these proteins control transcription...
- Structural and Kinetic Analysis of Substrate Binding to the Sialyltransferase Cst-II from Campylobacter jejuni
[作者:Lee, HJ; Lairson, LL; Rich, JR; Lameignere, E; Wakarchuk, WW; Withers, SG; Strynadka, NCJ,期刊:Journal of Biological Chemistry, 页码:35922-35932 , 文章类型: Article,,卷期:2011年286-41]
- Background: The transfer of sialic acids is catalyzed by a set of sialyltransferases with defined specificities. Results: We solved the ternary complex of the sialyltransferase Cst-II and kinetically characterized its me...
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