- Timing molecular motion and production with a synthetic transcriptional clock
[作者:Franco, E; Friedrichs, E; Kim, J; Jungmann, R; Murray, R; Winfree, E; Simmel, FC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E784-E793 , 文章类型: Article,,卷期:2011年108-40]
- The realization of artificial biochemical reaction networks with unique functionality is one of the main challenges for the development of synthetic biology. Due to the reduced number of components, biochemical circuits ...
- Misfolded human tRNA isodecoder binds and neutralizes a 3 ' UTR-embedded Alu element
[作者:Rudinger-Thirion, J; Lescure, A; Paulus, C; Frugier, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E794-E802 , 文章类型: Article,,卷期:2011年108-40]
- Several classes of small noncoding RNAs are key players in cellular metabolism including mRNA decoding, RNA processing, and mRNA stability. Here we show that a tRNAAsp isodecoder, corresponding to a human tRNA-derived se...
- Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes
[作者:Wesolowski, D; Tae, HS; Gandotra, N; Llopis, P; Shen, N; Altman, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16582-16587 , 文章类型: Article,,卷期:2011年108-40]
- Basic peptides covalently linked to nucleic acids, or chemically modified nucleic acids, enable the insertion of such a conjugate into bacteria grown in liquid medium and mammalian cells in tissue culture. A unique pepti...
- Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini
[作者:Panchenko, T; Sorensen, TC; Woodcock, CL; Kan, ZY; Wood, S; Resch, MG; Luger, K; Englander, SW; Hansen, JC; Black, BE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16588-16593 , 文章类型: Article,,卷期:2011年108-40]
- Centromere protein A (CENP-A) is a histone H3 variant that marks centromere location on the chromosome. To study the subunit structure and folding of human CENP-A-containing chromatin, we generated a set of nucleosomal a...
- Remote control of regioselectivity in acyl-acyl carrier protein-desaturases
[作者:Guy, JE; Whittle, E; Moche, M; Lengqvist, J; Lindqvist, Y; Shanklin, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16594-16599 , 文章类型: Article,,卷期:2011年108-40]
- Regiospecific desaturation of long-chain saturated fatty acids has been described as approaching the limits of the discriminatory power of enzymes because the substrate entirely lacks distinguishing features close to the...
- Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase
[作者:Takeuchi, H; Fernandez-Valdivia, RC; Caswell, DS; Nita-Lazar, A; Rana, NA; Garner, TP; Weldeghiorghis, TK; Macnaughtan, MA; Jafar-Nejad, H; Haltiwanger, RS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16600-16605 , 文章类型: Article,,卷期:2011年108-40]
- Mutations in rumi result in a temperature-sensitive loss of Notch signaling in Drosophila. Drosophila Rumi is a soluble, endoplasmic reticulum-retained protein with a CAP10 domain that functions as a protein O-glucosyltr...
- Phase separation in solutions of monoclonal antibodies and the effect of human serum albumin
[作者:Wang, Y; Lomakin, A; Latypov, RF; Benedek, GB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16606-16611 , 文章类型: Article,,卷期:2011年108-40]
- We report the observation of liquid-liquid phase separation in a solution of human monoclonal antibody, IgG2, and the effects of human serum albumin, a major blood protein, on this phase separation. We find a significant...
- Speed limit of protein folding evidenced in secondary structure dynamics
[作者:Lin, MM; Mohammed, OF; Jas, GS; Zewail, AH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16622-16627 , 文章类型: Article,,卷期:2011年108-40]
- As the simplest and most prevalent motif of protein folding, alpha-helix initiation is the starting point of macromolecular complexity. In this work, helix initiation was directly measured via ultrafast temperature-jump ...
- Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching
[作者:Kaiser, HJ; Orlowski, A; Rog, T; Nyholm, TKM; Chai, WG; Feizi, T; Lingwood, D; Vattulainen, I; Simons, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16628-16633 , 文章类型: Article,,卷期:2011年108-40]
- Theoretical studies predict hydrophobic matching between transmembrane domains of proteins and bilayer lipids to be a physical mechanism by which membranes laterally self-organize. We now experimentally study the direct ...
- Protein interactions central to stabilizing the K(+) channel selectivity filter in a four-sited configuration for selective K(+) permeation
[作者:Sauer, DB; Zeng, WZ; Raghunathan, S; Jiang, YX,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16634-16639 , 文章类型: Article,,卷期:2011年108-40]
- The structural and functional conversion of the nonselective NaK channel to a K(+) selective channel (NaK2K) allows us to identify two key residues, Tyr and Asp in the filter sequence of TVGYGD, that participate in inter...
- Random phase detection in multidimensional NMR
[作者:Maciejewski, MW; Fenwick, M; Schuyler, AD; Stern, AS; Gorbatyuk, V; Hoch, JC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16640-16644 , 文章类型: Article,,卷期:2011年108-40]
- Despite advances in resolution accompanying the development of high-field superconducting magnets, biomolecular applications of NMR require multiple dimensions in order to resolve individual resonances, and the achievabl...
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