- Synthesis and anticancer activities of some novel 2-(benzo[d]thiazol-2-yl)-8-substituted-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones
[作者:Reis, RD; Azevedo, EC; de Souza, MCBV; Ferreira, VF; Montenegro, RC; Araujo, AJ; Pessoa, C; Costa-Lotufo, LV; de Moraes, MO; Filho, JDBM; de Souza, AMT; de Carvalho, NC; Castro, HC; Rodrigues, CR; Vasconcelos, TRA,期刊:European Journal of Medicinal Chemistry, 页码:1448-1452 , 文章类型: Article,,卷期:2011年46-4]
- A series of 2-(benzo[d]thiazol-2-yl)-8-substituted-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones (3a-g) have been synthesized and evaluated for their in vitro antiproliferative activities against four human cancer cell lines: MD...
- Viral surface glycoproteins, gp120 and gp41, as potential drug targets against HIV-1: Brief overview one quarter of a century past the approval of zidovudine, the first anti-retroviral drug
[作者:Teixeira, C; Gomes, JRB; Gomes, P; Maurel, F,期刊:European Journal of Medicinal Chemistry, 页码:979-992 , 文章类型: Review,,卷期:2011年46-4]
- The first anti-HIV drug, zidovudine (AZT), was approved by the FDA a quarter of a century ago, in 1985. Currently, anti-HIV drug-combination therapies only target HIV-1 protease and reverse transcriptase. Unfortunately, ...
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