- MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets
[作者:Ooi, AGL; Sahoo, D; Adorno, M; Wang, YL; Weissman, IL; Park, CY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21505-21510 , 文章类型: Article,,卷期:2010年107-50]
- MicroRNAs profoundly impact hematopoietic cells by regulating progenitor cell-fate decisions, as well as mature immune effector function. However to date, microRNAs that regulate hematopoietic stem cell (HSC) function ha...
- Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129
[作者:Mugler, JP; Altes, TA; Ruset, IC; Dregely, IM; Mata, JF; Miller, GW; Ketel, S; Ketel, J; Hersman, FW; Ruppert, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21707-21712 , 文章类型: Article,,卷期:2010年107-50]
- Despite a myriad of technical advances in medical imaging, as well as the growing need to address the global impact of pulmonary diseases, such as asthma and chronic obstructive pulmonary disease, on health and quality o...
- Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis
[作者:Henry, CJ; Marusyk, A; Zaberezhnyy, V; Adane, B; DeGregori, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21713-21718 , 文章类型: Article,,卷期:2010年107-50]
- Aging is associated with the functional decline of cells, tissues, and organs. At the same time, age is the single most important prognostic factor in the development of most human cancers, including chronic myelogenous ...
- Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation (vol 107, pg 18575, 2010)
[作者:Veiga, P; Gallini, CA; Beal, C; Michaud, M; Delaney, ML; DuBois, A; Khlebnikov, A; Vlieg, JETV; Punit, S; Glickman, JN; Onderdonk, A; Glimcher, LH; Garrett, WS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21943-21943 , 文章类型: Correction,,卷期:2010年107-50]
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- Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes (vol 107, pg 18132, 2010)
[作者:Veiga, P; Gallini, CA; Beal, C; Michaud, M; Delaney, ML; DuBois, A; Khlebnikov, A; Vlieg, JETV; Punit, S; Glickman, JN; Onderdonk, A; Glimcher, LH; Garrett, WS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21943-21943 , 文章类型: Correction,,卷期:2010年107-50]
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- A 1,200-year perspective of 21st century drought in southwestern North America
[作者:Woodhouse, CA; Meko, DM; MacDonald, GM; Stahle, DW; Cooke, ER,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21283-21288 , 文章类型: Article,,卷期:2010年107-50]
- A key feature of anticipated 21st century droughts in Southwest North America is the concurrence of elevated temperatures and increased aridity. Instrumental records and paleoclimatic evidence for past prolonged drought ...
- Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi
[作者:Ko, G; Paradise, S; Chen, H; Graham, M; Vecchi, M; Bianchi, F; Cremona, O; Di Fiore, PP; De Camilli, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21511-21516 , 文章类型: Article,,卷期:2010年107-50]
- Epsin is a ubiquitin-binding endocytic adaptor, which is highly concentrated at clathrin-coated pits and coordinates acquisition of bilayer curvature with coat recruitment and cargo selection. Epsin is encoded by three d...
- Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia
[作者:Paulsson, K; Forestier, E; Lilljebjorn, H; Heldrup, J; Behrendtz, M; Young, BD; Johansson, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21719-21724 , 文章类型: Article,,卷期:2010年107-50]
- High hyperdiploid acute lymphoblastic leukemia ( ALL) is one of the most common malignancies in children. It is characterized by gain of chromosomes, typically +X, +4, +6, +10, +14, +17, +18, and +21, +21; little is know...
- Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancer
[作者:Latimer, JJ; Johnson, JM; Kelly, CM; Miles, TD; Beaudry-Rodgers, KA; Lalanne, NA; Vogel, VG; Kanbour-Shakir, A; Kelley, JL; Johnson, RR; Grant, SG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21725-21730 , 文章类型: Article,,卷期:2010年107-50]
- The molecular etiology of breast cancer has proven to be remarkably complex. Most individual oncogenes are disregulated in only approximately 30% of breast tumors, indicating that either very few molecular alterations ar...
- Tailor-made RNAi knockdown against triplet repeat disease-causing alleles
[作者:Takahashi, M; Watanabe, S; Murata, M; Furuya, H; Kanazawa, I; Wada, K; Hohjoh, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21731-21736 , 文章类型: Article,,卷期:2010年107-50]
Nucleotide variations, including SNPs, in the coding regions of disease genes are important targets for RNAi treatment, which is a promising medical treatment for intractable diseases such as triplet repeat diseases. ...
- Forest responses to increasing aridity and warmth in the southwestern United States
[作者:Williams, AP; Allen, CD; Millar, CI; Swetnam, TW; Michaelsen, J; Still, CJ; Leavitt, SW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21289-21294 , 文章类型: Article,,卷期:2010年107-50]
- In recent decades, intense droughts, insect outbreaks, and wildfires have led to decreasing tree growth and increasing mortality in many temperate forests. We compared annual tree-ring width data from 1,097 populations i...
- The major alpha-tubulin K40 acetyltransferase alpha TAT1 promotes rapid ciliogenesis and efficient mechanosensation
[作者:Shida, T; Cueva, JG; Xu, ZJ; Goodman, MB; Nachury, MV,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21517-21522 , 文章类型: Article,,卷期:2010年107-50]
- Long-lived microtubules found in ciliary axonemes, neuronal processes, and migrating cells are marked by alpha-tubulin acetylation on lysine 40, a modification that takes place inside the microtubule lumen. The physiolog...
- Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling
[作者:Fillmore, CM; Gupta, PB; Rudnick, JA; Caballero, S; Keller, PJ; Lander, ES; Kuperwasser, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21737-21742 , 文章类型: Article,,卷期:2010年107-50]
- Many tumors contain heterogeneous populations of cells, only some of which exhibit increased tumorigenicity and resistance to anticancer therapies. Evidence suggests that these aggressive cancer cells, often termed "canc...
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