- Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation
[作者:Vasen, HFA; Wasser, M; van Mil, A; Tollenaar, RA; Konstantinovski, M; Gruis, NA; Bergman, W; Hes, FJ; Hommes, DW; Offerhaus, GJA; Morreau, H; Bonsing, BA; Cappel, WHDTN,期刊:Gastroenterology, 页码:850-856 , 文章类型: Article,,卷期:2011年140-3]
- BACKGROUND & AIMS: Surveillance of high-risk groups for pancreatic cancer might increase early detection and treatment outcomes. Individuals with germline mutations in p16-Leiden have a lifetime risk of 15% to 20% of dev...
- A Role for the Ca2+ Channel TRPML1 in Gastric Acid Secretion, Based on Analysis of Knockout Mice
[作者:Chandra, M; Zhou, H; Li, Q; Muallem, S; Hofmann, SL; Soyombo, AA,期刊:Gastroenterology, 页码:857-U249 , 文章类型: Article,,卷期:2011年140-3]
- BACKGROUND & AIMS: Mutations in TRPML1, a lysosomal Ca2+-permeable TRP channel, lead to mucolipidosis type IV, a neurodegenerative lysosomal storage disease. An unusual feature of mucolipidosis type IV is constitutive ac...
- Rab27b Localizes to the Tubulovesicle Membranes of Gastric Parietal Cells and Regulates Acid Secretion
[作者:Suda, J; Zhu, LX; Okamoto, CT; Karvar, S,期刊:Gastroenterology, 页码:868-U262 , 文章类型: Article,,卷期:2011年140-3]
- BACKGROUND & AIMS: Rabs are monomeric guanosine triphosphatases that regulate membrane trafficking and acid secretion in gastric parietal cells. Using a proteomics approach, we identified a new Rab, Rab27b, in tubulovesi...
- Inhibition of Gastric Carcinogenesis by the Hormone Gastrin Is Mediated by Suppression of TFF1 Epigenetic Silencing
[作者:Tomita, H; Takaishi, S; Menheniott, TR; Yang, XD; Shibata, W; Jin, GC; Betz, KS; Kawakami, K; Minamoto, T; Tomasetto, C; Rio, MC; Lerkowit, N; Varro, A; Giraud, AS; Wang, TC,期刊:Gastroenterology, 页码:879-U293 , 文章类型: Article,,卷期:2011年140-3]
- BACKGROUND & AIMS: Epigenetic alterations have been correlated with field cancerization in human patients, but evidence from experimental models that specific epigenetic changes can initiate cancer has been lacking. Alth...
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