- Therapeutic potential of sulindac hydroxamic acid against human pancreatic and colonic cancer cells
[作者:Fogli, S; Banti, I; Stefanelli, F; Picchianti, L; Digiacomo, M; Macchia, M; Breschi, MC; Lapucci, A,期刊:European Journal of Medicinal Chemistry, 页码:5100-5107 , 文章类型: Article,,卷期:2010年45-11]
- The non-steroidal anti-inflammatory drug (NSAID) sulindac exhibits cyclooxygenase (COX)-dependent and COX-independent chemopreventive properties in human cancer. The present study was aimed at investigating whether the h...
- Synthesis and in vitro study of pseudo-peptide thioureas containing alpha-aminophosphonate moiety as potential antitumor agents
[作者:Liu, JZ; Song, BA; Fan, HT; Bhadury, PS; Wan, WT; Yang, S; Xu, WM; Wu, JA; Jin, LH; Wei, X; Hu, DY; Zeng, S,期刊:European Journal of Medicinal Chemistry, 页码:5108-5112 , 文章类型: Article,,卷期:2010年45-11]
- Twenty pseudo-peptide thioureas IIa-1 containing alpha-aminophosphonate moiety were synthesized from the reaction of chiral alpha-amino carboxamide derivatives Ia-c with O,O '-dialkylisothiocyanato(phenyl) methylphosphon...
- Antihypertensive activity of newer 1,4-dihydro-5-pyrimidine carboxamides: Synthesis and pharmacological evaluation
[作者:Alam, O; Khan, SA; Siddiqui, N; Ahsan, W; Verma, SP; Gilani, SJ,期刊:European Journal of Medicinal Chemistry, 页码:5113-5119 , 文章类型: Article,,卷期:2010年45-11]
- A number of 5-(4-substituted phenyl)-2-(substiruted benzylsulfanyl)-4-(substituted phenyl)-6-methyl-1,4-dihydro-5-pyrimidine carboxamides (1-30) were designed and synthesized keeping in view the structural requirements a...
- Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA
[作者:Yang, SH; Van, HTM; Le, TN; Khadka, DB; Cho, SH; Lee, KT; Lee, ES; Lee, YB; Ahn, CH; Cho, WJ,期刊:European Journal of Medicinal Chemistry, 页码:5493-5497 , 文章类型: Article,,卷期:2010年45-11]
- Various substituted 3-aryl-1-isoquinolinamines were designed and synthesized based on the previously constructed CoMFA model. Most of the synthesized compounds showed excellent potency in eight different human tumor cell...
- Synthesis and in vitro antibacterial activity of fluoroquinolone derivatives containing 3-(N '-alkoxycarbamimidoyl)-4-(alkoxyimino) pyrrolidines
[作者:Guo, QA; Feng, LS; Liu, ML; Zhang, YB; Chai, Y; Lv, K; Guo, HY; Han, LY,期刊:European Journal of Medicinal Chemistry, 页码:5498-5506 , 文章类型: Article,,卷期:2010年45-11]
- A series of novel 7-[3-(N'-alkoxycarbamimidoyl)-4-(alkoxyimino)pyrrolidin-1-yl] fluoroquinolone derivatives were designed, synthesized and characterized by H-1 NMR, MS and HRMS. These fluoroquinolones were screened for t...
- Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted beta-carbolines
[作者:Ma, CM; Cao, RH; Shi, BX; Zhou, XT; Ma, Q; Sun, J; Guo, LA; Yi, W; Chen, ZY; Song, HC,期刊:European Journal of Medicinal Chemistry, 页码:5513-5519 , 文章类型: Article,,卷期:2010年45-11]
- The condensation of alkylenediamine with ethyl beta-carboline-1-carboxylate and 1-bromo-beta-carboline gave beta-carboline-1-carboxamides and 1-amino-beta-carbolines, respectively. Some of these beta-carbolines were acti...
- Antioxidant activity of unexplored indole derivatives: Synthesis and screening
[作者:Estevao, MS; Carvalho, LC; Ribeiro, D; Couto, D; Freitas, M; Gomes, A; Ferreira, LM; Fernandes, E; Marques, MMB,期刊:European Journal of Medicinal Chemistry, 页码:4869-4878 , 文章类型: Article,,卷期:2010年45-11]
- The present study envisaged the development of novel antioxidant candidates using the indole scaffold. Several tryptophan and tryptamine derivatives were synthesized, in particular prenylated indole compounds, and their ...
- QSAR and docking studies of novel antileishmanial diaryl sulfides and sulfonamides
[作者:Goodarzi, M; da Cunha, EFF; Freitas, MP; Ramalho, TC,期刊:European Journal of Medicinal Chemistry, 页码:4879-4889 , 文章类型: Article,,卷期:2010年45-11]
- Leishmaniasis is a neglected disease transmitted in many tropical and sub-tropical countries, with few studies devoted to its treatment. In this work, the activities of two antileishmanial compound classes were modeled u...
- Ru(eta(6)-arene) complexes of combretastatin-analogous oxazoles with enhanced anti-tumoral impact
[作者:Biersack, B; Effenberger, K; Knauer, S; Ocker, M; Schobert, R,期刊:European Journal of Medicinal Chemistry, 页码:4890-4896 , 文章类型: Article,,卷期:2010年45-11]
- Oxazole-bridged combretastatin A-4 analogues bind to tubulin and exert anti-vascular and anti-angiogenic effects. When linked to Ru(eta(6)-arene) complex fragments, conjugates with additional cytotoxic activity result wh...
- Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents
[作者:Kumar, GVS; Prasad, YR; Mallikarjuna, BP; Chandrashekar, SM,期刊:European Journal of Medicinal Chemistry, 页码:5120-5129 , 文章类型: Article,,卷期:2010年45-11]
- A series of novel clubbed Isopropylthiazole derivatives triazolothiadiazines 2a-g, dihydro triazolothiadiazoles 3a-g, thioxotriazoles 4a-d, triazolothiadiazole 5, arylideneamino triazolethiones 7a-h and oxadiazolethiones...
- Synthesis, characterization, oxidative degradation, antibacterial activity and acetylcholinesterase/butyrylcholinesterase inhibitory effects of some new phosphorus(V) hydrazides
[作者:Gholivand, K; Hosseini, Z; Farshadian, S; Naderi-Manesh, H,期刊:European Journal of Medicinal Chemistry, 页码:5130-5139 , 文章类型: Article,,卷期:2010年45-11]
- Some new phosphorus(V) hydrazides 1a-12a were synthesized and characterized by H-1, C-13, P-31 NMR, IR spectroscopy and elemental analysis. Moreover, the interaction of Cu(M)(2)center dot nH(2)O with 1a, 3a and 7a gave 4...
- Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives
[作者:Gavara, L; Saugues, E; Alves, G; Debiton, E; Anizon, F; Moreau, P,期刊:European Journal of Medicinal Chemistry, 页码:5520-5526 , 文章类型: Article,,卷期:2010年45-11]
- The synthesis of new pyrazolo[3,4-g]quinoxaline derivatives, as well as their Pim kinases (Pim-1, Pim-2, Pim-3) inhibitory potencies and in vitro antiproliferative activities toward a human fibroblast primary culture and...
- The preparation of bi-functional organophosphine oxides as potential antitumor agents
[作者:Lam, KH; Chui, CH; Gambari, R; Wong, RSM; Cheng, GYM; Lau, FY; Lai, PBS; Tong, SW; Chan, KW; Wong, WY; Chan, ASC; Tang, JCO,期刊:European Journal of Medicinal Chemistry, 页码:5527-5530 , 文章类型: Article,,卷期:2010年45-11]
- Following our previously reported pyridinyl phosphine oxides as antitumor agents, we targeted the commercially available C-2-axial chiral organophosphine ligand catalysts, such as 2,2'-bis(diphenylphosphino)-1,1'-binapht...
- Synthesis of N-substituted Clausenamide analogues
[作者:Li, XZ; Zhu, CJ; Li, CH; Wu, KM; Huang, DF; Huang, LA,期刊:European Journal of Medicinal Chemistry, 页码:5531-5538 , 文章类型: Article,,卷期:2010年45-11]
- A practical synthesis of N-substituted Clausenamide analogues, including (-) and (+) CM1, Piracetam analogue "I and Nefiracetam analogue 2, have been developed. (C) 2010 Elsevier Masson SAS. All rights reserved.
- Synthesis and reactivity studies on new copper(II) complexes: DNA binding, generation of phenoxyl radical, SOD and nuclease activities (vol 45, pg 3770, 2010)
[作者:Ghosh, K; Kumar, P; Tyagi, N; Singh, UP; Aggarwal, V; Baratto, MC,期刊:European Journal of Medicinal Chemistry, 页码:5539-5539 , 文章类型: Correction,,卷期:2010年45-11]
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